Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide

Primer Autor
Islam, Muhammad Torequl
Co-autores
Hossain, Rajib
Quispe, Cristina
Herrera-Bravo, Jesus
Beltran, Jorge F.
Shaheen, Shabnum
Cruz-Martins, Natalia
Martorell, Miquel
Kumar, Manoj
Sharifi-Rad, Javad
Ozdemir, Fethi Ahmet
Setzer, William N.
Alshehri, Mohammed M.
Calina, Daniela
Cho, William C.
Título
Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide
Editorial
HINDAWI LTD
Revista
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Lenguaje
en
Resumen
Andrographolide (ANDRO), a bitter diterpene lactone found in Andrographis paniculata (Burm.f.) Nees, possesses several biological effects such as antioxidant, anti-inflammatory, and organo-protective effects. Scientific reports suggest that it also has neuroprotective capacity in various test systems. The purpose of this review was to synthesize the neuropharmacological properties of ANDRO and highlight the molecular mechanisms of action that highlight these activities. A careful search was done in PubMed and Google Scholar databases using specific keywords. Findings suggest that ANDRO possess neuroprotective, analgesic, and antifatigue effects. Prominent effects were stated on neuro-inflammation, cerebral ischemia, Alzheimer's and Parkinson's diseases, multiple sclerosis, and brain cancer in mice and rats. Furthermore, ANDRO and its derivatives can enhance memory and learning capacity in experimental animals (rats) without causing any toxicity in the brain. Thus, ANDRO may be one of the most promising plant-based psychopharmacological lead compounds for new drug development.
Tipo de Recurso
artículo de revisión
Description
AcknowledgmentsThis work was supported by the CONICYT PIA/APOYO CCTE AFB170007.
AgradecimientosEste trabajo contó con el apoyo del CONICYT PIA/APOYO CCTE AFB170007.
doi
10.1155/2022/3079577
Formato Recurso
PDF
Palabras Claves
COGNITIVE IMPAIRMENT
ALZHEIMERS-DISEASE
OXIDATIVE STRESS
IN-VITRO
PANICULATA
ACTIVATION
MANAGEMENT
CELLS
ENCEPHALOMYELITIS
INFLAMMATION
Ubicación del archivo
http://dx.doi.org/10.1155/2022/3079577
Categoría OCDE
Biología Celular
Materias
DETERIORO COGNITIVO
ENFERMEDAD DE ALZHEIMER
ESTRÉS OXIDATIVO
IN-VITRO
PANICULATA
ACTIVACIÓN
MANEJO
CÉLULAS
ENCEFALOMIELITIS
INFLAMACIÓN
Título de la cita (Recomendado-único)
Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID AFB170007
Id de Web of Science
WOS:000769453100006
Colecciones
Colección Publicaciones Científicas
Colección ANID
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