Repositorio UFRO · Omeka S

Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide

Primer Autor	Islam, Muhammad Torequl
Co-autores	Hossain, Rajib Quispe, Cristina Herrera-Bravo, Jesus Beltran, Jorge F. Shaheen, Shabnum Cruz-Martins, Natalia Martorell, Miquel Kumar, Manoj Sharifi-Rad, Javad Ozdemir, Fethi Ahmet Setzer, William N. Alshehri, Mohammed M. Calina, Daniela Cho, William C.
Título	Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide
Editorial	HINDAWI LTD
Revista	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Lenguaje	en
Resumen	Andrographolide (ANDRO), a bitter diterpene lactone found in Andrographis paniculata (Burm.f.) Nees, possesses several biological effects such as antioxidant, anti-inflammatory, and organo-protective effects. Scientific reports suggest that it also has neuroprotective capacity in various test systems. The purpose of this review was to synthesize the neuropharmacological properties of ANDRO and highlight the molecular mechanisms of action that highlight these activities. A careful search was done in PubMed and Google Scholar databases using specific keywords. Findings suggest that ANDRO possess neuroprotective, analgesic, and antifatigue effects. Prominent effects were stated on neuro-inflammation, cerebral ischemia, Alzheimer's and Parkinson's diseases, multiple sclerosis, and brain cancer in mice and rats. Furthermore, ANDRO and its derivatives can enhance memory and learning capacity in experimental animals (rats) without causing any toxicity in the brain. Thus, ANDRO may be one of the most promising plant-based psychopharmacological lead compounds for new drug development.
Tipo de Recurso	artículo de revisión
Description	AcknowledgmentsThis work was supported by the CONICYT PIA/APOYO CCTE AFB170007. AgradecimientosEste trabajo contó con el apoyo del CONICYT PIA/APOYO CCTE AFB170007.
doi	10.1155/2022/3079577
Formato Recurso	PDF
Palabras Claves	COGNITIVE IMPAIRMENT ALZHEIMERS-DISEASE OXIDATIVE STRESS IN-VITRO PANICULATA ACTIVATION MANAGEMENT CELLS ENCEPHALOMYELITIS INFLAMMATION
Ubicación del archivo	http://dx.doi.org/10.1155/2022/3079577
Categoría OCDE	Biología Celular
Materias	DETERIORO COGNITIVO ENFERMEDAD DE ALZHEIMER ESTRÉS OXIDATIVO IN-VITRO PANICULATA ACTIVACIÓN MANEJO CÉLULAS ENCEFALOMIELITIS INFLAMACIÓN
Disciplinas de la OCDE	Farmacología y Farmacia Neurociencias Química Orgánica
Título de la cita (Recomendado-único)	Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID AFB170007
Id de Web of Science	WOS:000769453100006