Repositorio UFRO · Omeka S

Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review

Primer Autor	Duque, Galo
Co-autores	Manterola, Carlos Otzen, Tamara Arias, Cristina Palacios, Dennise Mora, Miriann Galindo, Bryan Pablo Holguin, Juan Albarracin, Lorena
Título	Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review
Editorial	SAGE PUBLICATIONS LTD
Revista	CLINICAL MEDICINE INSIGHTS-ONCOLOGY
Lenguaje	en
Resumen	Background: Breast cancer (BC) is the most common neoplasm in women worldwide. Liquid biopsy (LB) is a non-invasive diagnostic technique that allows the analysis of biomarkers in different body fluids, particularly in peripheral blood and also in urine, saliva, nipple discharge, volatile respiratory fluids, nasal secretions, breast milk, and tears. The objective was to analyze the available evidence related to the use of biomarkers obtained by LB for the early diagnosis of BC. Methods: Articles related to the use of biomarkers for the early diagnosis of BC due to LB, published between 2010 and 2022, from the databases (WoS, EMBASE, PubMed, and SCOPUS) were included. The MInCir diagnostic scale was applied in the articles to determine their methodological quality (MQ). Descriptive statistics were used, as well as determination of weighted averages of each variable, to analyze the extracted data. Sensitivity, specificity, and area under the curve values for specific biomarkers (individual or in panels) are described. Results: In this systematic review (SR), 136 articles met the selection criteria, representing 17 709 patients with BC. However, 95.6% were case-control studies. In 96.3% of cases, LB was performed in peripheral blood samples. Most of the articles were based on microRNA (miRNA) analysis. The mean MQ score was 25/45 points. Sensitivity, specificity, and area under the curve values for specific biomarkers (individual or in panels) have been found. Conclusions: The determination of biomarkers through LB is a useful mechanism for the diagnosis of BC. The analysis of miRNA in peripheral blood is the most studied methodology. Our results indicate that LB has a high sensitivity and specificity for the diagnosis of BC, especially in early stages.
Tipo de Recurso	artículo de revisión
doi	10.1177/11795549221134831
Formato Recurso	PDF
Palabras Claves	Breast neoplasms liquid biopsy early diagnosis microRNAs sensitivity and specificity breast cancer CELL-FREE DNA PERIPHERAL-BLOOD CDKN2A P14(ARF)/P16(INK4A) CIRCULATING MICRORNAS CLINICAL-SIGNIFICANCE ABERRANT METHYLATION PROMOTER SEQUENCES POTENTIAL MARKER MESSENGER-RNA SERUM
Ubicación del archivo	http://dx.doi.org/10.1177/11795549221134831
Categoría OCDE	Oncología
Materias	Neoplasias de mama biopsia líquida diagnóstico precoz microARN sensibilidad y especificidad cáncer de mama ADN LIBRE DE CÉLULAS SANGRE-PERIFÉRICA CDKN2A P14(ARF)/P16(INK4A) MICRORNAS CIRCULANTES SIGNIFICADO-CLÍNICO METILACIÓN ABERRANTE SECUENCIAS PROMOTORAS MARCADOR DE POTENCIAL ARN MENSAJERO SUERO
Disciplinas de la OCDE	Oncología Biotecnología Relacionada con la Salud Biología Molecular
Versión del recurso (Recomendado-único)	version publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000888159000001
Título de la cita (Recomendado-único)	Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review
Identificador del recurso (Mandatado-único)	artículo de revisión
License	CC BY NC 4.0
Condición de la licencia (Recomendado-repetible)	CC BY NC 4.0