Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review
| Primer Autor |
Duque, Galo
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| Co-autores |
Manterola, Carlos
Otzen, Tamara
Arias, Cristina
Palacios, Dennise
Mora, Miriann
Galindo, Bryan
Pablo Holguin, Juan
Albarracin, Lorena
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| Título |
Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review
|
| Editorial |
SAGE PUBLICATIONS LTD
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| Revista |
CLINICAL MEDICINE INSIGHTS-ONCOLOGY
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| Lenguaje |
en
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| Resumen |
Background: Breast cancer (BC) is the most common neoplasm in women worldwide. Liquid biopsy (LB) is a non-invasive diagnostic technique that allows the analysis of biomarkers in different body fluids, particularly in peripheral blood and also in urine, saliva, nipple discharge, volatile respiratory fluids, nasal secretions, breast milk, and tears. The objective was to analyze the available evidence related to the use of biomarkers obtained by LB for the early diagnosis of BC. Methods: Articles related to the use of biomarkers for the early diagnosis of BC due to LB, published between 2010 and 2022, from the databases (WoS, EMBASE, PubMed, and SCOPUS) were included. The MInCir diagnostic scale was applied in the articles to determine their methodological quality (MQ). Descriptive statistics were used, as well as determination of weighted averages of each variable, to analyze the extracted data. Sensitivity, specificity, and area under the curve values for specific biomarkers (individual or in panels) are described. Results: In this systematic review (SR), 136 articles met the selection criteria, representing 17 709 patients with BC. However, 95.6% were case-control studies. In 96.3% of cases, LB was performed in peripheral blood samples. Most of the articles were based on microRNA (miRNA) analysis. The mean MQ score was 25/45 points. Sensitivity, specificity, and area under the curve values for specific biomarkers (individual or in panels) have been found. Conclusions: The determination of biomarkers through LB is a useful mechanism for the diagnosis of BC. The analysis of miRNA in peripheral blood is the most studied methodology. Our results indicate that LB has a high sensitivity and specificity for the diagnosis of BC, especially in early stages.
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| Tipo de Recurso |
artículo de revisión
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| doi |
10.1177/11795549221134831
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| Formato Recurso |
PDF
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| Palabras Claves |
Breast neoplasms
liquid biopsy
early diagnosis
microRNAs
sensitivity and specificity
breast cancer
CELL-FREE DNA
PERIPHERAL-BLOOD
CDKN2A P14(ARF)/P16(INK4A)
CIRCULATING MICRORNAS
CLINICAL-SIGNIFICANCE
ABERRANT METHYLATION
PROMOTER SEQUENCES
POTENTIAL MARKER
MESSENGER-RNA
SERUM
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| Ubicación del archivo | |
| Categoría OCDE |
Oncología
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| Materias |
Neoplasias de mama
biopsia líquida
diagnóstico precoz
microARN
sensibilidad y especificidad
cáncer de mama
ADN LIBRE DE CÉLULAS
SANGRE-PERIFÉRICA
CDKN2A P14(ARF)/P16(INK4A)
MICRORNAS CIRCULANTES
SIGNIFICADO-CLÍNICO
METILACIÓN ABERRANTE
SECUENCIAS PROMOTORAS
MARCADOR DE POTENCIAL
ARN MENSAJERO
SUERO
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| Título de la cita (Recomendado-único) |
Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review
|
| Identificador del recurso (Mandatado-único) |
artículo de revisión
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY NC 4.0
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| Condición de la licencia (Recomendado-repetible) |
CC BY NC 4.0
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| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
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| Id de Web of Science |
WOS:000888159000001
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