Role of copper nanoparticles in wound healing for chronic wounds: literature review

Primer Autor
Sandoval, Cristian
Co-autores
Salvo, Jessica
Título
Role of copper nanoparticles in wound healing for chronic wounds: literature review
Editorial
OXFORD UNIV PRESS
Revista
BURNS & TRAUMA
Lenguaje
en
Resumen
Chronic wounds are defined as wounds that fail to proceed through the normal phases of wound healing in an orderly and timely manner. The most common and inevitable impairment to wound healing is the installation of an infection, usually in the case of chronic wounds. Therefore, the objective of the present review was to identify the importance of copper nanoparticles in dressings for wound healing. Nanoparticles such as silver, gold and copper combat infectious processes through the inhibition of protein synthesis, peroxidation of the cell membrane and destroying the nucleic acids of bacteria and viruses. Among bioactive nanoparticles, copper plays a complex role in various cells, it modulates several cytokines and growth factor mechanisms of action and is essentially involved in all stages of the wound healing process. More importantly, copper plays a key role in skin regeneration and angiogenesis and accelerates the healing process through induction of vascular endothelial growth factor (VEGF) and angiogenesis by hypoxia-induced factor1-alpha (HIF-1 alpha) action where copper enhances HIF-1 alpha expression and HIF-1 alpha binding to the critical motifs in the promoter and putative enhancer regions of HIF-1-regulated genes.
Tipo de Recurso
artículo de revisión
doi
10.1093/burnst/tkab047
Formato Recurso
PDF
Palabras Claves
Angiogenesis
Antimicrobial
Nanoparticles
Regeneration
Wound healing
Chronic wound
VEGF
HIF-1 alpha
RNA-POLYMERASE-II
MATRIX METALLOPROTEINASES
SKIN
PROLIFERATION
MECHANISMS
EXPRESSION
POLYCOMB
INFLAMMATION
TRAFFICKING
GUIDELINES
Ubicación del archivo
http://dx.doi.org/10.1093/burnst/tkab047
Categoría OCDE
Medicina de emergencia
Dermatología
Cirugía
Materias
Angiogénesis
Antimicrobiano
Nanopartículas
Regeneración
Ciración de heridas
Herida crónica
VEGF
HIF-1 alfa
RNA-POLIMERASE-II
MATRIZ METALOPROTEINASAS
PIEL
PROLIFERACIÓN
MECANISMOS
EXPRESIÓN
POLYCOMB
INFLAMACIÓN
TRÁFICO
Directrices
Disciplinas de la OCDE
Biotecnología Relacionada con la Salud
Ingeniería Médica
Nanomateriales (Producción y Propiedades)
Título de la cita (Recomendado-único)
Role of copper nanoparticles in wound healing for chronic wounds: literature review
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY-NC 4.0
Condición de la licencia (Recomendado-repetible)
CC BY-NC 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000756882900004
Colecciones
Colección Publicaciones Científicas
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