Repositorio UFRO · Omeka S

Role of copper nanoparticles in wound healing for chronic wounds: literature review

Primer Autor	Sandoval, Cristian
Co-autores	Salvo, Jessica
Título	Role of copper nanoparticles in wound healing for chronic wounds: literature review
Editorial	OXFORD UNIV PRESS
Revista	BURNS & TRAUMA
Lenguaje	en
Resumen	Chronic wounds are defined as wounds that fail to proceed through the normal phases of wound healing in an orderly and timely manner. The most common and inevitable impairment to wound healing is the installation of an infection, usually in the case of chronic wounds. Therefore, the objective of the present review was to identify the importance of copper nanoparticles in dressings for wound healing. Nanoparticles such as silver, gold and copper combat infectious processes through the inhibition of protein synthesis, peroxidation of the cell membrane and destroying the nucleic acids of bacteria and viruses. Among bioactive nanoparticles, copper plays a complex role in various cells, it modulates several cytokines and growth factor mechanisms of action and is essentially involved in all stages of the wound healing process. More importantly, copper plays a key role in skin regeneration and angiogenesis and accelerates the healing process through induction of vascular endothelial growth factor (VEGF) and angiogenesis by hypoxia-induced factor1-alpha (HIF-1 alpha) action where copper enhances HIF-1 alpha expression and HIF-1 alpha binding to the critical motifs in the promoter and putative enhancer regions of HIF-1-regulated genes.
Tipo de Recurso	artículo de revisión
doi	10.1093/burnst/tkab047
Formato Recurso	PDF
Palabras Claves	Angiogenesis Antimicrobial Nanoparticles Regeneration Wound healing Chronic wound VEGF HIF-1 alpha RNA-POLYMERASE-II MATRIX METALLOPROTEINASES SKIN PROLIFERATION MECHANISMS EXPRESSION POLYCOMB INFLAMMATION TRAFFICKING GUIDELINES
Ubicación del archivo	http://dx.doi.org/10.1093/burnst/tkab047
Categoría OCDE	Medicina de emergencia Dermatología Cirugía
Materias	Angiogénesis Antimicrobiano Nanopartículas Regeneración Ciración de heridas Herida crónica VEGF HIF-1 alfa RNA-POLIMERASE-II MATRIZ METALOPROTEINASAS PIEL PROLIFERACIÓN MECANISMOS EXPRESIÓN POLYCOMB INFLAMACIÓN TRÁFICO Directrices
Disciplinas de la OCDE	Biotecnología Relacionada con la Salud Ingeniería Médica Nanomateriales (Producción y Propiedades)
Título de la cita (Recomendado-único)	Role of copper nanoparticles in wound healing for chronic wounds: literature review
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	version publicada
License	CC BY-NC 4.0
Condición de la licencia (Recomendado-repetible)	CC BY-NC 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000756882900004