Repositorio
Institucional

Page, David B.

Broeckx, Glenn

Jahangir, Chowdhury Arif

Jahangir, Chowdhury

Verbandt, Sara

Gupta, Rajarsi R.

Thagaard, Jeppe

Khiroya, Reena

Kos, Zuzana

Abduljabbar, Khalid

Acosta Haab, Gabriela

Acs, Balazs

Almeida, Jonas S.

Alvarado-Cabrero, Isabel

Azmoudeh-Ardalan, Farid

Badve, Sunil

Baharun, Nurkhairul Bariyah

Bellolio, Enrique R.

Bheemaraju, Vydehi

Blenman, Kim R. M.

Botinelly Mendonca Fujimoto, Luciana

Burgues, Octavio

Cheang, Maggie Chon U.

Ciompi, Francesco

Cooper, Lee A. D.

Coosemans, An

Corredor, German

Dantas Portela, Flavio Luis

Deman, Frederik

Demaria, Sandra

Dudgeon, Sarah N.

Elghazawy, Mahmoud

Ely, Scott

Fernandez-Martin, Claudio

Fineberg, Susan

Fox, Stephen B.

Gallagher, William M.

Giltnane, Jennifer M.

Gnjatic, Sacha

Gonzalez-Ericsson, Paula, I

Grigoriadis, Anita

Halama, Niels

Hanna, Matthew G.

Harbhajanka, Aparna

Hardas, Alexandros

Hart, Steven N.

Hartman, Johan

Hewitt, Stephen

Hida, Akira, I

Horlings, Hugo M.

Husain, Zaheed

Hytopoulos, Evangelos

Irshad, Sheeba

Janssen, Emiel A. M.

Kahila, Mohamed

Kataoka, Tatsuki R.

Kawaguchi, Kosuke

Kharidehal, Durga

Khramtsov, Andrey, I

Kiraz, Umay

Kirtani, Pawan

Kodach, Liudmila L.

Korski, Konstanty

Kovacs, Aniko

Laenkholm, Anne-Vibeke

Lang-Schwarz, Corinna

Larsimont, Denis

Lennerz, Jochen K.

Lerousseau, Marvin

Li, Xiaoxian

Ly, Amy

Madabhushi, Anant

Maley, Sai K.

Manur Narasimhamurthy, Vidya

Marks, Douglas K.

McDonald, Elizabeth S.

Mehrotra, Ravi

Michiels, Stefan

Minhas, Fayyaz ul Amir Afsar

Mittal, Shachi

Moore, David A.

Mushtaq, Shamim

Nighat, Hussain

Papathomas, Thomas

Penault-Llorca, Frederique

Perera, Rashindrie D.

Pinard, Christopher J.

Pinto-Cardenas, Juan Carlos

Pruneri, Giancarlo

Pusztai, Lajos

Sur, Daniel

Wen, Hannah Y.

Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

WILEY

JOURNAL OF PATHOLOGY

en

Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. & COPY, 2023 The Pathological Society of Great Britain and Ireland.

2023

artículo de revisión

10.1002/path.6165

PDF

spatial statistics

tumor infiltrating lymphocytes

TIL

sTIL score

Immunoscore

multispectral immunofluorescence

spatial heterogeneity

Oncología

Patología

estadísticas espaciales

linfocitos infiltrantes de tumores

HASTA

puntuación STIL

inmunopuntuación

inmunofluorescencia multiespectral

heterogeneidad espacial

514.0

532

artículo de revisión

versión publicada

CC BY-NC 4.0

CC BY-NC 4.0

acceso abierto

acceso abierto

WOS:001053470500001

0022-3417

Verde# hibrida

Oncología

Patología