Repositorio
Institucional

Sanhueza, Claudia

Vergara, Daniela

Chavez-Aravena, Catalina

Galvez-Jiron, Felipe

Chavez-Angel, Emigdio

Castro-Alvarez, Alejandro

Functionalizing Dendrimers for Targeted Delivery of Bioactive Molecules to Macrophages: A Potential Treatment for Mycobacterium tuberculosis Infection-A Review

MDPI

PHARMACEUTICALS

en

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that replicates inside human alveolar macrophages. This disease causes significant morbidity and mortality throughout the world. According to the World Health Organization 1.4 million people died of this disease in 2021. This indicates that despite the progress of modern medicine, improvements in diagnostics, and the development of drug susceptibility tests, TB remains a global threat to public health. In this sense, host-directed therapy may provide a new approach to the cure of TB, and the expression of miRNAs has been correlated with a change in the concentration of various inflammatory mediators whose concentrations are responsible for the pathophysiology of M. tuberculosis infection. Thus, the administration of miRNAs may help to modulate the immune response of organisms. However, direct administration of miRNAs, without adequate encapsulation, exposes nucleic acids to the activity of cytosolic nucleases, limiting their application. Dendrimers are a family of highly branched molecules with a well-defined architecture and a branched conformation which gives rise to cavities that facilitate physical immobilization, and functional groups that allow chemical interaction with molecules of interest. Additionally, dendrimers can be easily functionalized to target different cells, macrophages among them. In this sense, various studies have proposed the use of different cell receptors as target molecules to aim dendrimers at macrophages and thus release drugs or nucleic acids in the cell of interest. Based on the considerations, the primary objective of this review is to comprehensively explore the potential of functionalized dendrimers as delivery vectors for miRNAs and other therapeutic agents into macrophages. This work aims to provide insights into the use of functionalized dendrimers as an innovative approach for TB treatment, focusing on their ability to target and deliver therapeutic cargo to macrophages.

2023

artículo de revisión

10.3390/ph16101428

PDF

tuberculosis

Mycobacterium tuberculosis

miRNA

dendrimers

host directed therapy

Farmacología y farmacia

tuberculosis

Tuberculosis micobacteriana

miARN

dendrímeros

terapia dirigida por el huésped

artículo de revisión

versión publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:001099412900001

verde# dorado

Farmacología y farmacia

ANID-FONDECYT 3220479

ANID-FONDECYT 3210533

ANID-FONDECYT 11200620

ANID FONDECYT 3220479

ANID 3210533

ANID 11200620