Extracellular vesicles in mammalian reproduction: a review
| Primer Autor |
Arias, Maria Elena
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| Co-autores |
Muñoz, Erwin L.
Fuentes, Fernanda B.
Felmer, Ricardo N.
Yeste, Marc
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| Título |
Extracellular vesicles in mammalian reproduction: a review
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| Editorial |
CAMBRIDGE UNIV PRESS
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| Revista |
ZYGOTE
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| Lenguaje |
en
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| Resumen |
Over the last decades, extracellular vesicles (EVs) have been found to be implicated in a complex universal mechanism of communication between different cell types. EVs are nanostructures of lipid nature that have an exosomal or ectosomal biogenesis, responsible for the intercellular transport of proteins, lipids, carbohydrates, nucleic acids, ions, among other molecules. The content of EVs can vary due to various factors such as hormonal stimuli, non-physiological conditions, metabolic state, etc. Once EVs reach their target cell, they can modulate processes such as gene expression, metabolism, response to external factors, and can even be associated with the delivery of molecules involved in epigenetic inheritance processes in germ cells. In mammalian reproduction, EVs have been shown to play an important role, either in vivo or in vitro, modulating a variety of processes in sperm, oocytes and embryos, and in their respective environments. Moreover, EVs represent a biodegradable, harmless and specific vehicle, which makes them attractive allies to consider when improving assisted reproductive technologies (ARTs). Therefore, the present review aims to describe the content of the main EVs involved in mammalian reproduction and how they can vary due to different factors, as well as to detail how EVs modulate, directly or indirectly, different molecular processes in gametes and embryos. In addition, we will highlight the mechanisms that remain to be elucidated. We will also propose new perspectives according to the characteristics of each particular EV to improve the different ARTs.
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| Tipo de Recurso |
artículo de revisión
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| Derecho de Acceso |
metadata
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| Description |
The authors gratefully acknowledge funding support from project DI21-0040, Universidad de La Frontera and Doctoral scholarship CONICYT - ANID 21191434, Chile.
Los autores agradecen el apoyo financiero del proyecto DI21-0040, Universidad de La Frontera y la beca de doctorado CONICYT - ANID 21191434, Chile.
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| doi |
10.1017/S0967199422000090
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| Formato Recurso |
PDF
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| Palabras Claves |
Embryos
Extracellular Vesicle
miRNA
Oocytes
Sperm
PROTEIN-TYROSINE PHOSPHORYLATION
MIGRATION INHIBITORY FACTOR
MEDIATED GENE-TRANSFER
FOLLICULAR-FLUID
EXOSOMAL MICRORNAS
ACROSOME REACTION
HUMAN EPIDIDYMIS
POLYOL PATHWAY
SPERM MATURATION
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| Categoría OCDE |
híbrido
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| Materias |
femenino
Biología Celular
Biología del desarrollo
Biología reproductiva
Embriones
Vesícula extracelular
miARN
Ovocitos
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| Título de la cita (Recomendado-único) |
FOSFORILACIÓN DE PROTEÍNA-TIROSINA
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| Página de inicio (Recomendado-único) |
FLUIDO FOLICULAR
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| Página final (Recomendado-único) |
MICRORNAS EXOSÓMICAS
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| Identificador del recurso (Mandatado-único) |
artículo de revisión
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| Versión del recurso (Recomendado-único) |
versión publicada
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| Derechos de acceso |
metadata
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| Access Rights |
metadata
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
UFRO DI21-0040
ANID 21191434
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| Id de Web of Science |
WOS:000804998300001
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