Extracellular vesicles in mammalian reproduction: a review

Primer Autor
Arias, Maria Elena
Co-autores
Muñoz, Erwin L.
Fuentes, Fernanda B.
Felmer, Ricardo N.
Yeste, Marc
Título
Extracellular vesicles in mammalian reproduction: a review
Editorial
CAMBRIDGE UNIV PRESS
Revista
ZYGOTE
Lenguaje
en
Resumen
Over the last decades, extracellular vesicles (EVs) have been found to be implicated in a complex universal mechanism of communication between different cell types. EVs are nanostructures of lipid nature that have an exosomal or ectosomal biogenesis, responsible for the intercellular transport of proteins, lipids, carbohydrates, nucleic acids, ions, among other molecules. The content of EVs can vary due to various factors such as hormonal stimuli, non-physiological conditions, metabolic state, etc. Once EVs reach their target cell, they can modulate processes such as gene expression, metabolism, response to external factors, and can even be associated with the delivery of molecules involved in epigenetic inheritance processes in germ cells. In mammalian reproduction, EVs have been shown to play an important role, either in vivo or in vitro, modulating a variety of processes in sperm, oocytes and embryos, and in their respective environments. Moreover, EVs represent a biodegradable, harmless and specific vehicle, which makes them attractive allies to consider when improving assisted reproductive technologies (ARTs). Therefore, the present review aims to describe the content of the main EVs involved in mammalian reproduction and how they can vary due to different factors, as well as to detail how EVs modulate, directly or indirectly, different molecular processes in gametes and embryos. In addition, we will highlight the mechanisms that remain to be elucidated. We will also propose new perspectives according to the characteristics of each particular EV to improve the different ARTs.
Tipo de Recurso
artículo de revisión
Derecho de Acceso
metadata
Description
The authors gratefully acknowledge funding support from project DI21-0040, Universidad de La Frontera and Doctoral scholarship CONICYT - ANID 21191434, Chile.
Los autores agradecen el apoyo financiero del proyecto DI21-0040, Universidad de La Frontera y la beca de doctorado CONICYT - ANID 21191434, Chile.
doi
10.1017/S0967199422000090
Formato Recurso
PDF
Palabras Claves
Embryos
Extracellular Vesicle
miRNA
Oocytes
Sperm
PROTEIN-TYROSINE PHOSPHORYLATION
MIGRATION INHIBITORY FACTOR
MEDIATED GENE-TRANSFER
FOLLICULAR-FLUID
EXOSOMAL MICRORNAS
ACROSOME REACTION
HUMAN EPIDIDYMIS
POLYOL PATHWAY
SPERM MATURATION
Categoría OCDE
híbrido
Materias
femenino
Biología Celular
Biología del desarrollo
Biología reproductiva
Embriones
Vesícula extracelular
miARN
Ovocitos
Disciplinas de la OCDE
Biología Reproductiva
Biología Celular
Tecnologías que involucran la manipulación de Células , Tejidos, órganos o el organismo completo (Reproducción Asistida)
Título de la cita (Recomendado-único)
FOSFORILACIÓN DE PROTEÍNA-TIROSINA
Página de inicio (Recomendado-único)
FLUIDO FOLICULAR
Página final (Recomendado-único)
MICRORNAS EXOSÓMICAS
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
versión publicada
Derechos de acceso
metadata
Access Rights
metadata
Referencia del Financiador (Mandatado si es aplicable-repetible)
UFRO DI21-0040
ANID 21191434
Id de Web of Science
WOS:000804998300001
Colecciones
Colección Publicaciones Científicas
Colección ANID
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