OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer

Primer Autor
Figueroa, Rodolfo G.
Co-autores
Valente, Mauro
Guarda, Jaime
Leiva, Jorge
Quilaguilque, Eduardo
Casanelli, Bryan
Leyton, Fernando
Título
OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer
Editorial
WILEY
Revista
X-RAY SPECTROMETRY
Lenguaje
en
Resumen
A novel and suitable energy-dispersive X-ray fluorescent (EDXRF) device, currently at the prototype stage, the Project OXIRIS (Orthovoltage X-Ray-Induced Radiation System), is presented for the simultaneous detection and treatment of cancer diseases. Monte Carlo simulation and experimental results of EDXRF signals from a small deep artificial tumor consisting of a solution of gold nanoparticles bio-targeted and immersed in a tissue-bioequivalent matrix are presented and compared. Briefly, the device consists of a dynamic orthovoltage X-ray fluence concentration coupled to confocal with an EDXRF system along with a sample holder for 3D scanning, all integrated and controlled by a dedicated software capable of controlling the whole operation functionalities: the X-ray source, the rotating arm, the sample holder, and the detection system. The software also includes dedicated subroutines for X-ray fluorescent spectra processing to correlate K-lines signal at each acquisition position with the corresponding high atomic number elements' concentration to produce a 3D distribution according to the user-defined grid. The confocal configuration ensures that the detected signal comes exclusively from the excited volume as defined by the bulk of the focal spot. Hence, the 3D image is achieved by scanning the sample holder through the movement of the sample-carrier stretcher moved by step motors in the 3 coordinated axes. The feasibility of the proposed methodology and the design of the prototype have been successfully demonstrated experimentally, targeting gold nanoparticles in water-equivalent phantoms.
Tipo de Recurso
artículo original
Description
ANID Chile FONDECYT Program, Grant/Award Number: 1171729
ANID Chile Programa FONDECYT, Número de Beca/Premio: 1171729
doi
10.1002/xrs.3272
Formato Recurso
PDF
Palabras Claves
3D high atomic number elements' mapping
biomarked tumor targeting
convergent X-ray beam
OXIRIS project
X-RAY-FLUORESCENCE
GOLD NANOPARTICLES
BIOMARKERS
TOXICITY
MACRO
Ubicación del archivo
http://dx.doi.org/10.1002/xrs.3272
Categoría OCDE
Espectroscopia
Materias
Mapeo 3D de elementos de alto número atómico
dirigido a tumores biomarcados
haz de rayos X convergente
proyecto OXIRIS
FLUORESCENCIA DE RAYOS X
NANOPARTÍCULAS DE ORO
BIOMARCADORES
TOXICIDAD
MACRO
Disciplinas de la OCDE
Ingeniería Médica
Otras Especialidades de la Física
Oncología
Título de la cita (Recomendado-único)
OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer
Página de inicio (Recomendado-único)
251
Página final (Recomendado-único)
261
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
metadata
Access Rights
metadata
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID-FONDECYT 1171729
ANID FONDECYT 1171729
Id de Web of Science
WOS:000707935600001
Colecciones
Colección Publicaciones Científicas
Colección ANID
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