Repositorio
Institucional

Brebi, Priscilla

Zanella, Louise

Riquelme, Ismael

Reyes, Maria Elena

Infante, Francisca

Reyes, Soledad

Ramirez, Eugenio

Ili, Carmen

Genome analysis suggests HTLV-1aA introduction in Chile related to migrations of ancestral indigenous populations

ELSEVIER

VIRUS RESEARCH

en

The human T cell lymphotropic virus type 1 (HTLV-1), unlike other RNA viruses such as HIV, has a stable genome and has infected humans since remote times. Although the HTLV-1 infection is endemic in South America, there is scarce information about HTLV-1 in Chile and its history of introduction. This study assessed the genomic content of HTLV-1 from Chile and its relationship with HTLV-1 lineages circulating worldwide by phylogenetic reconstruction and dating analyses. A total of 30 HTLV-1 genomes collected from the four continents were used to conduct dating analyses, including the first HTLV-1 genome from Amerindian/Mapuche ethnicity. Estimation was performed using a Bayesian Markov Chain Monte Carlo coalescent-based approach as implemented in the BEAST program. The time of the most recent ancestor of HTLV-1 from Chile was ~1409 years ago, which coincides with the period of Amerindian population expansion across South America. Our results suggest HTLV-1aA was possibly introduced in Chile during the migrations of the ancestral indigenous populations.

artículo original

This research was supported by National Funding for Scientific and Technologic Development of Chile (FONDECYT) [3210687 to LZ, 3170826 to IR, 11150622 to CI and 1210440 to PB] , Universidad de La Frontera [VRIP20P002 to LZ] , National Commission for Scientific and Technological Research (CONICYT) [21201835 to MR] , Direccion de Investigacion, Universidad de La Frontera (DIUFRO) [DIM20-0019 to LZ, DI20-0160 to CI and DI20-0128 to PB] , and Direccion de Inves-tigacion, Universidad Autonoma (UA) [DIUA 226-2021 to IR] .

Esta investigación fue apoyada por el Fondo Nacional para el Desarrollo Científico y Tecnológico de Chile (FONDECYT) [3210687 a LZ, 3170826 a IR, 11150622 a CI y 1210440 a PB], Universidad de La Frontera [VRIP20P002 a LZ], Comisión Nacional de Investigaciones Científicas y Tecnológicas (CONICYT) [21201835 a MR] , Dirección de Investigación, Universidad de La Frontera (DIUFRO) [DIM20-0019 a LZ, DI20-0160 a CI y DI20-0128 a PB], y Dirección de Investigación, Universidad Autónoma (UA) [DIUA 226-2021 a IR] .

10.1016/j.virusres.2022.198687

PDF

Human T-cell lymphotropic virus (HTLV)

Genome dating analysis

Chile

ancestral migrations

VIRUS TYPE-I

CELL LYMPHOTROPIC VIRUS

PHYLOGENETIC SUBTYPES

HUMAN RETROVIRUSES

CLONAL EXPANSION

CENTRAL-AFRICA

TYPE-1 HTLV-1

PROVIRUS DNA

T-CELLS

LEUKEMIA

Virología

Virus linfotrópico de células T humanas (HTLV)

Análisis de datación del genoma

Chile

migraciones ancestrales

VIRUS TIPO I

VIRUS LINFOTRÓPICO DE CÉLULAS

SUBTIPOS FILOGENÉTICOS

RETROVIRUS HUMANOS

EXPANSIÓN CLONAL

ÁFRICA CENTRAL

TIPO-1 HTLV-1

PROVIRUS ADN

CÉLULAS T

LEUCEMIA

Genome analysis suggests HTLV-1aA introduction in Chile related to migrations of ancestral indigenous populations

artículo original

version publicada

0

metadata

metadata

ANID-FONDECYT 3210687

ANID-FONDECYT 3170826

ANID-FONDECYT 11150622

ANID-FONDECYT 1210440

UFRO VRIP20P002

UFRO DIM20-0019

UFRO DI20-0160

UFRO DI20-0128

UA DIUA 226-2021

ANID FONDECYT 3210687

ANID FONDECYT 3170826

ANID FONDECYT 11150622

ANID FONDECYT 1210440

WOS:000784295000006