Repositorio UFRO · Omeka S

Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Triggers Inflammation and Endothelial Dysfunction in BALB/c Mice: A Pilot Study

Primer Autor	Salazar, Luis A.
Co-autores	Rojas, Gabriel A. Saavedra, Nicolas Saavedra, Kathleen Hevia, Montserrat Morales, Cristian Lanas, Fernando Salazar, Luis A.
Título	Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Triggers Inflammation and Endothelial Dysfunction in BALB/c Mice: A Pilot Study
Editorial	MDPI
Revista	TOXICS
Lenguaje	en
Resumen	The particulate matter present in air pollution is a complex mixture of solid and liquid particles that vary in size, origin, and composition, among which are polycyclic aromatic hydrocarbons (PAHs). Although exposure to PAHs has become an important risk factor for cardiovascular disease, the mechanisms by which these compounds contribute to increased cardiovascular risk have not been fully explored. The aim of the present study was to evaluate the effects of PAH exposure on systemic pro-inflammatory cytokines and markers of endothelial dysfunction. An intervention was designed using a murine model composed of twenty BALB/c male mice separated into controls and three groups exposed to a mixture of phenanthrene, fluoranthene, and pyrene using three different concentrations. The serum levels of the inflammatory cytokines and gene expression of adhesion molecules located on endothelial cells along with inflammatory markers related to PAH exposure in aortic tissue were determined. Furthermore, the expression of the ICAM-1 and VCAM-1 proteins was evaluated. The data showed significant differences in IL-6 and IFN-gamma in the serum. In the gene expression, significant differences for ICAM-1, VCAM-1, and E-Selectin were observed. The results suggest that phenanthrene, fluoranthene, and pyrene, present in air pollution, stimulate the increase in serum inflammatory cytokines and the expression of markers of endothelial dysfunction in the murine model studied, both relevant characteristics associated with the onset of disease atherosclerosis and cardiovascular disease.
Tipo de Recurso	artículo original
Description	This research was funded by FONDECYT-Chile [Grant numbers 1171618 and 1171765]. Esta investigación fue financiada por FONDECYT-Chile [Números de subvención 1171618 y 1171765].
doi	10.3390/toxics10090497
Formato Recurso	PDF
Palabras Claves	air pollution endothelium inflammation cardiovascular disease PARTICULATE MATTER AIR-POLLUTION CARDIOVASCULAR-DISEASE ADHESION MOLECULE-1 OXIDATIVE STRESS ATHEROSCLEROSIS ASSOCIATION PARTICLES CYTOKINES ULTRAFINE
Ubicación del archivo	http://dx.doi.org/10.3390/toxics10090497
Categoría OCDE	Ciencias Ambientales Toxicología
Materias	contaminación del aire endotelio inflamación enfermedad cardiovascular MATERÍA PARTÍCULA CONTAMINACIÓN DEL AIRE ENFERMEDAD CARDIOVASCULAR ADHESIÓN MOLÉCULA-1 ESTRÉS OXIDATIVO ATEROSCLEROSIS ASOCIACIÓN PARTICULAS CITOQUINAS ULTRAFINO
Disciplinas de la OCDE	Sistema Cardiovascular y Cardiaco Toxicología Ciencias del Medio Ambiente
Título de la cita (Recomendado-único)	Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Triggers Inflammation and Endothelial Dysfunction in BALB/c Mice: A Pilot Study
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID-FONDECYT 1171618 ANID-FONDECYT 1171765 ANID FONDECYT 1171618 ANID FONDECYT 1171765
Id de Web of Science	WOS:000858764700001