Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Triggers Inflammation and Endothelial Dysfunction in BALB/c Mice: A Pilot Study
| Primer Autor |
Salazar, Luis A.
|
| Co-autores |
Rojas, Gabriel A.
Saavedra, Nicolas
Saavedra, Kathleen
Hevia, Montserrat
Morales, Cristian
Lanas, Fernando
Salazar, Luis A.
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| Título |
Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Triggers Inflammation and Endothelial Dysfunction in BALB/c Mice: A Pilot Study
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| Editorial |
MDPI
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| Revista |
TOXICS
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| Lenguaje |
en
|
| Resumen |
The particulate matter present in air pollution is a complex mixture of solid and liquid particles that vary in size, origin, and composition, among which are polycyclic aromatic hydrocarbons (PAHs). Although exposure to PAHs has become an important risk factor for cardiovascular disease, the mechanisms by which these compounds contribute to increased cardiovascular risk have not been fully explored. The aim of the present study was to evaluate the effects of PAH exposure on systemic pro-inflammatory cytokines and markers of endothelial dysfunction. An intervention was designed using a murine model composed of twenty BALB/c male mice separated into controls and three groups exposed to a mixture of phenanthrene, fluoranthene, and pyrene using three different concentrations. The serum levels of the inflammatory cytokines and gene expression of adhesion molecules located on endothelial cells along with inflammatory markers related to PAH exposure in aortic tissue were determined. Furthermore, the expression of the ICAM-1 and VCAM-1 proteins was evaluated. The data showed significant differences in IL-6 and IFN-gamma in the serum. In the gene expression, significant differences for ICAM-1, VCAM-1, and E-Selectin were observed. The results suggest that phenanthrene, fluoranthene, and pyrene, present in air pollution, stimulate the increase in serum inflammatory cytokines and the expression of markers of endothelial dysfunction in the murine model studied, both relevant characteristics associated with the onset of disease atherosclerosis and cardiovascular disease.
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| Tipo de Recurso |
artículo original
|
| Description |
This research was funded by FONDECYT-Chile [Grant numbers 1171618 and 1171765].
Esta investigación fue financiada por FONDECYT-Chile [Números de subvención 1171618 y 1171765].
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| doi |
10.3390/toxics10090497
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| Formato Recurso |
PDF
|
| Palabras Claves |
air pollution
endothelium
inflammation
cardiovascular disease
PARTICULATE MATTER
AIR-POLLUTION
CARDIOVASCULAR-DISEASE
ADHESION MOLECULE-1
OXIDATIVE STRESS
ATHEROSCLEROSIS
ASSOCIATION
PARTICLES
CYTOKINES
ULTRAFINE
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| Ubicación del archivo | |
| Categoría OCDE |
Ciencias Ambientales
Toxicología
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| Materias |
contaminación del aire
endotelio
inflamación
enfermedad cardiovascular
MATERÍA PARTÍCULA
CONTAMINACIÓN DEL AIRE
ENFERMEDAD CARDIOVASCULAR
ADHESIÓN MOLÉCULA-1
ESTRÉS OXIDATIVO
ATEROSCLEROSIS
ASOCIACIÓN
PARTICULAS
CITOQUINAS
ULTRAFINO
|
| Título de la cita (Recomendado-único) |
Polycyclic Aromatic Hydrocarbons (PAHs) Exposure Triggers Inflammation and Endothelial Dysfunction in BALB/c Mice: A Pilot Study
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 1171618
ANID-FONDECYT 1171765
ANID FONDECYT 1171618
ANID FONDECYT 1171765
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| Id de Web of Science |
WOS:000858764700001
|
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