Oral Supplementation of beta-Carotene Benefits the Hepatic Structure and Metabolism in Mice (Mus musculus) Exposed to A Chronic Ethanol Consumption

Primer Autor
Sandoval, Cristian
Co-autores
Vasquez, Belgica
Vasconcellos, Adriana
Souza-Mello, Vanessa
Adeli, Khosrow
Mandarim-De-Lacerda, Carlos
del Sol, Mariano
Título
Oral Supplementation of beta-Carotene Benefits the Hepatic Structure and Metabolism in Mice (Mus musculus) Exposed to A Chronic Ethanol Consumption
Editorial
UNIV KEBANGSAAN MALAYSIA
Revista
SAINS MALAYSIANA
Lenguaje
en
Resumen
Ethanol cannot be excreted and must be metabolized in the liver. Alcoholic liver disease is a blanket term for conditions related specifically to the liver and alcohol use. The study aimed to evaluate the metabolic, biochemical and histological effects of the oral supplementation with beta-carotene on the liver of C57BL/6 mice exposed to ethanol consumption. Thirty male C57BL/6 mice (Mus musculus) were divided into six experimental groups: Control (C), Low-dose alcohol (LA), Moderate-dose alcohol (MA), beta-carotene (B), Low-dose alcohol+beta-carotene (LA+B) and Moderate-dose alcohol+beta-carotene (MA+B) group. One-way ANOVA was used. The greatest intake of calories was noted in the LA (65.4 +/- 12.5 kJ) and MA (68.6 +/- 18.6 kJ) groups. The LA+B and MA+B groups shown an improvement in the HOMA-IR index (8.7 +/- 2.4 and 6.7 +/- 3.5, respectively), increased ADH levels (16.2 +/- 1.6 and 18.9 +/- 0.5 pmol/minmL(-1), respectively) and decreased insulin levels (14.0 +/- 3.3 and 10.6 +/- 5.7 mu UmL(-1), respectively). It was also observed that oral supplementation with beta-carotene improved the hepatic parenchyma in the L4+B group, showing normal-sized hepatocytes, whereas in the MA+B group it relieved the structural damage, revealing fewer lipid droplets than the MA group.
Tipo de Recurso
artículo original
Description
Universidad de La Frontera [DIUFRO DI20-0003]; CONICYT-PCHA/Doctorado Nacional [2015-21150991]; Canadian Institutes for Health Research
Universidad de La Frontera; CONICYT-PCHA/Doctorado Nacional; Canadian Institutes for Health Research(Canadian Institutes of Health Research (CIHR))
This Project was funded by Universidad de La Frontera, DIUFRO DI20-0003; CONICYT-PCHA/Doctorado Nacional/2015-21150991 and the Canadian Institutes for Health Research awarded to Dr. Adeli.
Este Proyecto fue financiado por la Universidad de La Frontera, DIUFRO DI20-0003; CONICYT-PCHA/Doctorado Nacional/2015-21150991 y los Institutos Canadienses de Investigación en Salud otorgados al Dr. Adeli.
doi
10.17576/jsm-2022-5101-23
Formato Recurso
PDF
Palabras Claves
Alcohol abuse
alcoholic liver disease
antioxidants
antioxidant effects
LIVER-DISEASE
VITAMIN-A
ALDEHYDE DEHYDROGENASE
LIPID-PEROXIDATION
INSULIN-RESISTANCE
HOMEOSTASIS MODEL
ALPHA-TOCOPHEROL
LUNG-CANCER
ALCOHOL
ANTIOXIDANT
Ubicación del archivo
http://dx.doi.org/10.17576/jsm-2022-5101-23
Categoría OCDE
Ciencias Multidisciplinarias
Materias
Abuso de alcohol
enfermedad hepática alcohólica
antioxidantes
efectos antioxidantes
ENFERMEDAD DEL HÍGADO
VITAMINA-A
ALDEHÍDO DESHIDROGENASA
PEROXIDACIÓN LÍPIDA
RESISTENCIA A LA INSULINA
MODELO DE HOMEOSTASIS
ALFA-TOCOFEROL
CÁNCER DE PULMÓN
ALCOHOL
ANTIOXIDANTE
Disciplinas de la OCDE
Gastroenterología y Hepatología
Toxicología
Bioquímica
Título de la cita (Recomendado-único)
Oral Supplementation of beta-Carotene Benefits the Hepatic Structure and Metabolism in Mice (Mus musculus) Exposed to A Chronic Ethanol Consumption
Página de inicio (Recomendado-único)
285
Página final (Recomendado-único)
296
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)
UFRO DIUFRO DI20-0003#CONICYT 2015-21150991
UFRO DIUFRO DI20-0003
CONICYT [2015-21150991
Id de Web of Science
WOS:000767367700023
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