Repositorio
Institucional

Sandoval, Cristian

Vasquez, Belgica

Vasconcellos, Adriana

Souza-Mello, Vanessa

Adeli, Khosrow

Mandarim-De-Lacerda, Carlos

del Sol, Mariano

Oral Supplementation of beta-Carotene Benefits the Hepatic Structure and Metabolism in Mice (Mus musculus) Exposed to A Chronic Ethanol Consumption

UNIV KEBANGSAAN MALAYSIA

SAINS MALAYSIANA

en

Ethanol cannot be excreted and must be metabolized in the liver. Alcoholic liver disease is a blanket term for conditions related specifically to the liver and alcohol use. The study aimed to evaluate the metabolic, biochemical and histological effects of the oral supplementation with beta-carotene on the liver of C57BL/6 mice exposed to ethanol consumption. Thirty male C57BL/6 mice (Mus musculus) were divided into six experimental groups: Control (C), Low-dose alcohol (LA), Moderate-dose alcohol (MA), beta-carotene (B), Low-dose alcohol+beta-carotene (LA+B) and Moderate-dose alcohol+beta-carotene (MA+B) group. One-way ANOVA was used. The greatest intake of calories was noted in the LA (65.4 +/- 12.5 kJ) and MA (68.6 +/- 18.6 kJ) groups. The LA+B and MA+B groups shown an improvement in the HOMA-IR index (8.7 +/- 2.4 and 6.7 +/- 3.5, respectively), increased ADH levels (16.2 +/- 1.6 and 18.9 +/- 0.5 pmol/minmL(-1), respectively) and decreased insulin levels (14.0 +/- 3.3 and 10.6 +/- 5.7 mu UmL(-1), respectively). It was also observed that oral supplementation with beta-carotene improved the hepatic parenchyma in the L4+B group, showing normal-sized hepatocytes, whereas in the MA+B group it relieved the structural damage, revealing fewer lipid droplets than the MA group.

artículo original

Universidad de La Frontera [DIUFRO DI20-0003]; CONICYT-PCHA/Doctorado Nacional [2015-21150991]; Canadian Institutes for Health Research

Universidad de La Frontera; CONICYT-PCHA/Doctorado Nacional; Canadian Institutes for Health Research(Canadian Institutes of Health Research (CIHR))

This Project was funded by Universidad de La Frontera, DIUFRO DI20-0003; CONICYT-PCHA/Doctorado Nacional/2015-21150991 and the Canadian Institutes for Health Research awarded to Dr. Adeli.

Este Proyecto fue financiado por la Universidad de La Frontera, DIUFRO DI20-0003; CONICYT-PCHA/Doctorado Nacional/2015-21150991 y los Institutos Canadienses de Investigación en Salud otorgados al Dr. Adeli.

10.17576/jsm-2022-5101-23

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Alcohol abuse

alcoholic liver disease

antioxidants

antioxidant effects

LIVER-DISEASE

VITAMIN-A

ALDEHYDE DEHYDROGENASE

LIPID-PEROXIDATION

INSULIN-RESISTANCE

HOMEOSTASIS MODEL

ALPHA-TOCOPHEROL

LUNG-CANCER

ALCOHOL

ANTIOXIDANT

Ciencias Multidisciplinarias

Abuso de alcohol

enfermedad hepática alcohólica

antioxidantes

efectos antioxidantes

ENFERMEDAD DEL HÍGADO

VITAMINA-A

ALDEHÍDO DESHIDROGENASA

PEROXIDACIÓN LÍPIDA

RESISTENCIA A LA INSULINA

MODELO DE HOMEOSTASIS

ALFA-TOCOFEROL

CÁNCER DE PULMÓN

ALCOHOL

ANTIOXIDANTE

Gastroenterología y Hepatología

Toxicología

Bioquímica

Oral Supplementation of beta-Carotene Benefits the Hepatic Structure and Metabolism in Mice (Mus musculus) Exposed to A Chronic Ethanol Consumption

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artículo original

version publicada

acceso abierto

acceso abierto

UFRO DIUFRO DI20-0003#CONICYT 2015-21150991

UFRO DIUFRO DI20-0003

CONICYT [2015-21150991

WOS:000767367700023