Repositorio
Institucional

Cancino, Margarita

Sepulveda-Pezoa, Luciana

Gomez-Perez, Daniela

Ortiz, Manuel S.

Salinas-Rehbein, Belen

Factores de riesgo cardiometabólico y funcionamiento cognitivo: el rol de la reserva cognitiva

SOC MEDICA SANTIAGO

REVISTA MEDICA DE CHILE

es

Background: Several risk factors are associated with cognitive impairment in older people, but little attention has been paid to cardiometabolic variables, as well as how cognitive reserve can mediate this association. Aim: To determine the association of cardiometabolic risk factors with cognitive functioning and whether the cognitive reserve mediates this association. Material and Methods: A cross-sectional study with 300 participants with a median age of 56 years (53% male) was conducted. Participants had a cognitive functioning assessment. Fasting glucose, HDL-cholesterol, and blood pressure were measured Results: A Structural Equation Modeling, revealed a direct effect of cardiometabolic latent risk factors on both a cognitive functioning (beta = -.204, p = .056), and cognitive reserve factors (beta = -.236, p = .04). Cognitive reserve was directly associated with cognitive functioning (beta = .327, p = .01), but did not mediate the association between the cardiometabolic risk factors and cognitive functioning (beta = .077, p= .07). The overall goodness of fitness was excellent chi(2) ( 50) = 58.357, p = .195, comparative fit index = .980, Tucker-Lewis Index = .974, root mean square error of approximation = .023 and Standardized Root Mean Square Residual = .041. Conclusions A direct effect of cardiometabolic risk factors on cognitive functioning was observed.

artículo original

10.4067/s0034-98872021000801134

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Aging

Cardiometabolic Risk Factors

Cognition

Cognitive Reserve

DELAYED CUED-RECALL

OLDER-ADULTS

HDL-CHOLESTEROL

WORKING-MEMORY

ATHEROSCLEROSIS

HYPERTENSION

POPULATION

IMMEDIATE

MIDLIFE

RESERVE

Medicina general e interna

Envejecimiento

Factores de riesgo cardiometabólico

Cognición

Reserva cognitiva

RECUERDO RETARDADO

ADULTOS MAYORES

COLESTEROL-HDL

MEMORIA-TRABAJADORA

ATEROSCLEROSIS

HIPERTENSIÓN

POBLACIÓN

INMEDIATA

MEDIDA VIDA

RESERVA

Neurociencias

Endocrinología y Metabolismo (Incluye Diabetes, Hormonas)

Otros Temas de Medicina Básica

Factores de riesgo cardiometabólico y funcionamiento cognitivo: el rol de la reserva cognitiva

1134

1140

artículo original

version publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:000733663600004