Repositorio
Institucional

Farias, Jorge G.

Contreras, Pablo

Zamorano, Mauricio

Ulloa-Rodriguez, Patricio

Beltran, Jorge F.

Risopatron, Jennie

Figueroa, Elias

Valdebenito, Ivan

Diversity of chromatin condensation patterns, nuclear reorganization, evolution and phylogenetic distribution of sperm nuclear basic proteins in fish

SPRINGER

REVIEWS IN FISH BIOLOGY AND FISHERIES

en

One of the most astonishing examples of chromatin remodelling occurs during the maturation of male germ cells, where changes in protein structure, as well as chromatin compaction, take place. During the post-meiotic formation of sperm (spermiogenesis), chromatin appears super-condensed, and transcriptionally inactive, allowing for a more hydrodynamic sperm head, and preventing physical and chemical damage to DNA. DNA is closely condensed in the mature sperm nucleus through its linkage with sperm-specific nuclear proteins called sperm nuclear basic proteins, clustered in three categories: histones, protamines and protamine-like proteins. Fish represent a unique group of vertebrates, including species with specific proteins from each type, such as Sparus aurata, Mullus surmuletus, Dicentrarchus labrax, and Scyliorhinus canicula, which display histones, protamine-like proteins, protamines, and keratinous protamines, respectively. Phylogenetically, these proteins are evolutionarily related, presenting a sporadic and non-random distribution, as a result of vertical evolution, where only histones would be found in more primitive species, and protamines would be restricted to those species located at the uppermost branches of the phylogenetic tree. The relative frequency of this transition is almost insignificant during the differentiation of genera, and species, and very small amongst different families, but, very noticeable amongst different orders. Thus, the aim of this study is to gather the existing background related to sperm nuclear basic proteins in fish, showing a general perspective of the state of the art about diversity, and nuclear reorganization of sperm chromatin during spermiogenesis, and the evolution and phylogenetic distribution of these proteins in fish sperm.

artículo de revisión

This study was financially supported by Project DIUFRO DI21-0111 and ANID-Subdirectorate of Human Capital/National Doctorate/2021-21212091.

Este estudio contó con el apoyo financiero del Proyecto DIUFRO DI21-0111 y ANID-Subdirección de Capital Humano/Doctorado Nacional/2021-21212091.

10.1007/s11160-021-09690-8

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Histones

Protamines

Protamine-like proteins

Spermatozoa

Sperm nuclear basic proteins

TO-PROTAMINE TRANSITION

HISTONE H1

SPERMIOGENESIS

SPERMATOGENESIS

VERTEBRATE

ORIGIN

ULTRASTRUCTURE

SEQUENCES

IDENTIFICATION

ORGANIZATION

Pesca

Biología marina y de agua dulce

Histonas

Protaminas

Proteínas similares a las protaminas

Espermatozoides

Proteínas básicas nucleares del esperma

TRANSICIÓN A PROTAMINA

HISTONA H1

ESPERMIOGÉNESIS

ESPERMATOGÉNESIS

VERTEBRADO

ORIGEN

ULTRAESTRUCTURA

SECUENCIAS

IDENTIFICACIÓN

ORGANIZACIÓN

Diversity of chromatin condensation patterns, nuclear reorganization, evolution and phylogenetic distribution of sperm nuclear basic proteins in fish

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artículo de revisión

version publicada

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acceso abierto

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ANID 21212091

UFRO DI21-0111

WOS:000725989700001