Association of fasting orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents

Primer Autor
Gahagan, Sheila
Co-autores
Lanuza, Fabian
Reyes, Marcela
Blanco, Estela
Burrows, Raquel
Peirano, Patricio
Algarin, Cecilia
Merono, Tomas
Título
Association of fasting orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
Editorial
PERGAMON-ELSEVIER SCIENCE LTD
Revista
PSYCHONEUROENDOCRINOLOGY
Lenguaje
en
Resumen
Orexin-A, a hormone secreted by orexin neurons, is involved in caloric-intake regulation. Current understanding is based primarily on animal studies. Studies of orexin in humans are scarce, and to our knowledge there are no prior studies in adolescents. We studied fasting Orexin-A levels related to energy intake at breakfast and a subsequent snack in adolescents (n = 668) from a longitudinal study in Chile. Body-Mass Index (BMI), components of the metabolic syndrome and fasting blood levels of leptin, insulin, ghrelin, and orexin-A were measured. Energy intake was calculated based on food weights before and after the standardized breakfast and subsequent snack. High energy intake was defined as = 75th percentile. We assessed the relationship between orexin-A and high energy intake, adjusting for confounders. Higher orexin levels were associated with high breakfast energy intake (OR: 1.21, 95%CI: 0.98-1.49). Conversely, those with higher orexin levels showed a nonsignificant trend for lower odds of high energy intake for the snack (OR: 0.87, 95%CI: 0.70-1.07). There was a significant interaction between high breakfast energy intake and orexin levels. Those who ate more calories at breakfast displayed a lower inhibitory effect of orexin on eating at the snack (p < 0.05). There was no significant interaction between weight status and orexin. In conclusion, orexin-A levels were associated with breakfast energy intake and inversely related with subsequent snack energy intake in participants whose caloric intake at breakfast was within the normal range. Based on these findings, it appears that the association of orexin-A with energy intake depends on eating behavior.
Tipo de Recurso
artículo original
doi
10.1016/j.psyneuen.2022.105679
Formato Recurso
PDF
Palabras Claves
Adolescent
Orexin
Caloric intake
Obesity
Appetite
IRON-DEFICIENCY ANEMIA
FOOD-INTAKE
LEPTIN
GHRELIN
OBESITY
Ubicación del archivo
http://dx.doi.org/10.1016/j.psyneuen.2022.105679
Categoría OCDE
Endocrinología y Metabolismo
Neurociencias
Psiquiatría
Materias
Adolescente
Orexin
Ingesta calórica
Obesidad
Apetito
ANEMIA POR DEFICIENCIA DE HIERRO
INGESTA DE ALIMENTOS
LEPTIN
GHRELIN
OBESIDAD
Título de la cita (Recomendado-único)
Association of fasting orexin-A levels with energy intake at breakfast and subsequent snack in Chilean adolescents
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000820119800010
Colecciones
Colección Publicaciones Científicas
Revisa las metricas alternativas de Almetrics
Revisa las citaciones de Dimensions