Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis

Primer Autor
Martorell, Miquel
Co-autores
Quispe, Cristina
Herrera-Bravo, Jesus
Khan, Khushbukhat
Javed, Zeeshan
Semwal, Prabhakar
Painuli, Sakshi
Kamiloglu, Senem
Calina, Daniela
Sharifi-Rad, Javad
Título
Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis
Editorial
SPRINGER HEIDELBERG
Revista
PROGRESS IN BIOMATERIALS
Lenguaje
en
Resumen
"Medicinal applications of turmeric-derived curcumin have been known to mankind for long ages. Its potential in managing ""cystic fibrosis"" has also been evaluated. This autosomal recessive genetic disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) which involves an impaired secretion of chloride ions and leads to hypersecretion of thick and sticky mucus and serious complications including airway obstruction, chronic lung infection, and inflammatory reactions. This narrative review aims to highlight the available evidence for the efficacy of curcumin nanoformulations in its potential treatment of cystic fibrosis. Recent research has shown that curcumin acts on the localized mutant CFTR ion channel at the plasma membrane. Preclinical studies have also shown that curcumin nanoformulations have promising effects in the treatment of cystic fibrosis. In this context, the purpose of this narrative review is to highlight the general bioactivity of curcumin, the types of formulations and related studies, thus opening new therapeutic perspectives for CF."
Tipo de Recurso
artículo de revisión
doi
10.1007/s40204-022-00198-3
Formato Recurso
PDF
Palabras Claves
Cystic fibrosis
Curcumin nanoparticles
Bioavailability
Molecular mechanisms
Signalling pathways
TRANSMEMBRANE CONDUCTANCE REGULATOR
MESOPOROUS SILICA NANOPARTICLES
PSEUDOMONAS-AERUGINOSA
PLGA NANOPARTICLES
CO-DELIVERY
DESIGN
EXPRESSION
STRATEGY
RESCUE
CFTR
Ubicación del archivo
http://dx.doi.org/10.1007/s40204-022-00198-3
Categoría OCDE
Ingeniería Biomédica
Ciencia de Materiales
Biomateriales
Materias
Fibrosis quística
Nanopartículas de curcumina
Biodisponibilidad
Mecanismos moleculares
Vías de señalización
REGULADOR DE CONDUCTANCIA TRANSMEMBRANA
NANOPARTÍCULAS DE SÍLICE MESOPOROS
PSEUDOMONAS-AERUGINOSA
NANOPARTÍCULAS PLGA
CO-ENTREGA
DISEÑO
EXPRESIÓN
ESTRATEGIA
RESCATE
CFTR
Disciplinas de la OCDE
Farmacología y Farmacia
Biotecnología Relacionada con la Salud
Genética Humana
Título de la cita (Recomendado-único)
Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis
Página de inicio (Recomendado-único)
321
Página final (Recomendado-único)
329
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
metadata
Access Rights
metadata
Identificador relacionado
PMC9626725
Id de Web of Science
WOS:000832809200001
Colecciones
Colección Publicaciones Científicas
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