Repositorio UFRO · Omeka S

Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis

Primer Autor	Martorell, Miquel
Co-autores	Quispe, Cristina Herrera-Bravo, Jesus Khan, Khushbukhat Javed, Zeeshan Semwal, Prabhakar Painuli, Sakshi Kamiloglu, Senem Calina, Daniela Sharifi-Rad, Javad
Título	Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis
Editorial	SPRINGER HEIDELBERG
Revista	PROGRESS IN BIOMATERIALS
Lenguaje	en
Resumen	"Medicinal applications of turmeric-derived curcumin have been known to mankind for long ages. Its potential in managing ""cystic fibrosis"" has also been evaluated. This autosomal recessive genetic disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) which involves an impaired secretion of chloride ions and leads to hypersecretion of thick and sticky mucus and serious complications including airway obstruction, chronic lung infection, and inflammatory reactions. This narrative review aims to highlight the available evidence for the efficacy of curcumin nanoformulations in its potential treatment of cystic fibrosis. Recent research has shown that curcumin acts on the localized mutant CFTR ion channel at the plasma membrane. Preclinical studies have also shown that curcumin nanoformulations have promising effects in the treatment of cystic fibrosis. In this context, the purpose of this narrative review is to highlight the general bioactivity of curcumin, the types of formulations and related studies, thus opening new therapeutic perspectives for CF."
Tipo de Recurso	artículo de revisión
doi	10.1007/s40204-022-00198-3
Formato Recurso	PDF
Palabras Claves	Cystic fibrosis Curcumin nanoparticles Bioavailability Molecular mechanisms Signalling pathways TRANSMEMBRANE CONDUCTANCE REGULATOR MESOPOROUS SILICA NANOPARTICLES PSEUDOMONAS-AERUGINOSA PLGA NANOPARTICLES CO-DELIVERY DESIGN EXPRESSION STRATEGY RESCUE CFTR
Ubicación del archivo	http://dx.doi.org/10.1007/s40204-022-00198-3
Categoría OCDE	Ingeniería Biomédica Ciencia de Materiales Biomateriales
Materias	Fibrosis quística Nanopartículas de curcumina Biodisponibilidad Mecanismos moleculares Vías de señalización REGULADOR DE CONDUCTANCIA TRANSMEMBRANA NANOPARTÍCULAS DE SÍLICE MESOPOROS PSEUDOMONAS-AERUGINOSA NANOPARTÍCULAS PLGA CO-ENTREGA DISEÑO EXPRESIÓN ESTRATEGIA RESCATE CFTR
Disciplinas de la OCDE	Farmacología y Farmacia Biotecnología Relacionada con la Salud Genética Humana
Título de la cita (Recomendado-único)	Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis
Página de inicio (Recomendado-único)	321
Página final (Recomendado-único)	329
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	version publicada
Condición de la licencia (Recomendado-repetible)	0
Derechos de acceso	metadata
Access Rights	metadata
Identificador relacionado	PMC9626725
Id de Web of Science	WOS:000832809200001