Cost Function Analysis Applied to Different Kinetic Release Models of Arrabidaea chica Verlot Extract from Chitosan/Alginate Membranes
| Primer Autor |
Hernandez-Montelongo, Jacobo
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| Co-autores |
Concha, Luis
Resende Pires, Ana Luiza
Moraes, Angela Maria
Mas-Hernandez, Elizabeth
Berres, Stefan
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| Título |
Cost Function Analysis Applied to Different Kinetic Release Models of Arrabidaea chica Verlot Extract from Chitosan/Alginate Membranes
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| Editorial |
MDPI
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| Revista |
POLYMERS
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| Lenguaje |
en
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| Resumen |
This work focuses on the mathematical analysis of the controlled release of a standardized extract of A. chica from chitosan/alginate (C/A) membranes, which can be used for the treatment of skin lesions. Four different types of C/A membranes were tested: a dense membrane (CA), a dense and flexible membrane (CAS), a porous membrane (CAP) and a porous and flexible membrane (CAPS). The Arrabidae chica extract release profiles were obtained experimentally in vitro using PBS at 37 degrees C and pH 7. Experimental data of release kinetics were analyzed using five classical models from the literature: Zero Order, First Order, Higuchi, Korsmeyer-Peppas and Weibull functions. Results for the Korsmeyer-Peppas model showed that the release of A. chica extract from four membrane formulations was by a diffusion through a partially swollen matrix and through a water filled network mesh, however, the Weibull model suggested that non-porous membranes (CA and CAS) had fractal geometry and that porous membranes (CAP and CAPS) have highly disorganized structures. Nevertheless, by applying an explicit optimization method that employs a cost function to determine the model parameters that best fit to experimental data, the results indicated that the Weibull model showed the best simulation for the release profiles from the four membranes: CA, CAS and CAP presented Fickian diffusion through a polymeric matrix of fractal geometry, and only the CAPS membrane showed a highly disordered matrix. The use of this cost function optimization had the significant advantage of higher fitting sensitivity.
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| Tipo de Recurso |
artículo original
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| Description |
This research was funded by FONDECYT, Chile grant number 11180395, the National Council for Scientific and Technological Development, Brazil grants 307829 /2018-9 and 152053/2014-0, the Coordination for the Improvement of Higher Education Personnel, Brazil finance code 001.
Esta investigación fue financiada por FONDECYT, Chile beca número 11180395, el Consejo Nacional de Desarrollo Científico y Tecnológico, Brasil beca 307829/2018-9 y 152053/2014-0, la Coordinación para el Perfeccionamiento del Personal de Educación Superior, Brasil código de financiación 001.
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| doi |
10.3390/polym14061109
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| Formato Recurso |
PDF
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| Palabras Claves |
cost function
controlled release
Arrabidae chica Verlot
chitosan
alginate membranes
DRUG-RELEASE
NUMERICAL IDENTIFICATION
PARAMETERS
MECHANISM
EVOLUTION
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| Ubicación del archivo | |
| Categoría OCDE |
Ciencia de los polímeros
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| Materias |
función de costo
liberación controlada
Arrabidae chica Verlot
quitosano
membranas de alginato
LIBERACIÓN DE MEDICAMENTOS
IDENTIFICACIÓN NUMÉRICA
PARAMETROS
MECANISMO
EVOLUCIÓN
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| Título de la cita (Recomendado-único) |
Cost Function Analysis Applied to Different Kinetic Release Models of Arrabidaea chica Verlot Extract from Chitosan/Alginate Membranes
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| Identificador del recurso (Mandatado-único) |
artículo original
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| Versión del recurso (Recomendado-único) |
version publicada
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| License |
CC BY 4.0
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| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
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| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 11180395
ANID FONDECYT 11180395
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| Id de Web of Science |
WOS:000774410900001
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cienciaabierta.ufro.cl
ciencia.abierta@ufrontera.cl