Repositorio
Institucional

Hernandez-Montelongo, Jacobo

Concha, Luis

Resende Pires, Ana Luiza

Moraes, Angela Maria

Mas-Hernandez, Elizabeth

Berres, Stefan

Cost Function Analysis Applied to Different Kinetic Release Models of Arrabidaea chica Verlot Extract from Chitosan/Alginate Membranes

MDPI

POLYMERS

en

This work focuses on the mathematical analysis of the controlled release of a standardized extract of A. chica from chitosan/alginate (C/A) membranes, which can be used for the treatment of skin lesions. Four different types of C/A membranes were tested: a dense membrane (CA), a dense and flexible membrane (CAS), a porous membrane (CAP) and a porous and flexible membrane (CAPS). The Arrabidae chica extract release profiles were obtained experimentally in vitro using PBS at 37 degrees C and pH 7. Experimental data of release kinetics were analyzed using five classical models from the literature: Zero Order, First Order, Higuchi, Korsmeyer-Peppas and Weibull functions. Results for the Korsmeyer-Peppas model showed that the release of A. chica extract from four membrane formulations was by a diffusion through a partially swollen matrix and through a water filled network mesh, however, the Weibull model suggested that non-porous membranes (CA and CAS) had fractal geometry and that porous membranes (CAP and CAPS) have highly disorganized structures. Nevertheless, by applying an explicit optimization method that employs a cost function to determine the model parameters that best fit to experimental data, the results indicated that the Weibull model showed the best simulation for the release profiles from the four membranes: CA, CAS and CAP presented Fickian diffusion through a polymeric matrix of fractal geometry, and only the CAPS membrane showed a highly disordered matrix. The use of this cost function optimization had the significant advantage of higher fitting sensitivity.

artículo original

This research was funded by FONDECYT, Chile grant number 11180395, the National Council for Scientific and Technological Development, Brazil grants 307829 /2018-9 and 152053/2014-0, the Coordination for the Improvement of Higher Education Personnel, Brazil finance code 001.

Esta investigación fue financiada por FONDECYT, Chile beca número 11180395, el Consejo Nacional de Desarrollo Científico y Tecnológico, Brasil beca 307829/2018-9 y 152053/2014-0, la Coordinación para el Perfeccionamiento del Personal de Educación Superior, Brasil código de financiación 001.

10.3390/polym14061109

PDF

cost function

controlled release

Arrabidae chica Verlot

chitosan

alginate membranes

DRUG-RELEASE

NUMERICAL IDENTIFICATION

PARAMETERS

MECHANISM

EVOLUTION

Ciencia de los polímeros

función de costo

liberación controlada

Arrabidae chica Verlot

quitosano

membranas de alginato

LIBERACIÓN DE MEDICAMENTOS

IDENTIFICACIÓN NUMÉRICA

PARAMETROS

MECANISMO

EVOLUCIÓN

Biomateriales (Relacionados con implantes médicos, dispositivos y Sensores)

Polímeros

Biotecnología Relacionada con la Salud

Cost Function Analysis Applied to Different Kinetic Release Models of Arrabidaea chica Verlot Extract from Chitosan/Alginate Membranes

artículo original

version publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

ANID-FONDECYT 11180395

ANID FONDECYT 11180395

WOS:000774410900001