Optimal Morphometric Characteristics of a Tubular Polymeric Scaffold to Promote Peripheral Nerve Regeneration: A Scoping Review
| Primer Autor |
Dias, Fernando Jose
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| Co-autores |
Alarcon Apablaza, Josefa
Lezcano, Maria Florencia
Godoy Sanchez, Karina
Oporto, Gonzalo H.
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| Título |
Optimal Morphometric Characteristics of a Tubular Polymeric Scaffold to Promote Peripheral Nerve Regeneration: A Scoping Review
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| Editorial |
MDPI
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| Revista |
POLYMERS
|
| Lenguaje |
en
|
| Resumen |
Cellular behavior in nerve regeneration is affected by the architecture of the polymeric nerve guide conduits (NGCs), therefore, design features of polymeric NGCs are critical for neural tissue engineering. Hence, the purpose of this scoping review is to summarize the adequate quantitative/morphometric parameters of the characteristics of NGC that provide a supportive environment for nerve regeneration, enhancing the understanding of a previous study. 394 studies were found, of which 29 studies were selected. The selected studies revealed four morphometric characteristics for promoting nerve regeneration: wall thickness, fiber size, pore size, and porosity. An NGC with a wall thickness between 250-400 mu m and porosity of 60-80%, with a small pore on the inner surface and a large pore on the outer surface, significantly favored nerve regeneration, resulting in an increase in nutrient permeability, retention of neurotrophic factors, and optimal mechanical properties. On the other hand, the superiority of electrospun fibers is described, however, the size of the fiber is controversial in the literature, obtaining optimal results in the range of 300 nm to 30 mu m. The incorporation of these optimal morphometric characteristics will encourage nerve regeneration and help reduce the number of experimental studies as it will provide the initial morphometric parameters for the preparation of an NGC.
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| Tipo de Recurso |
artículo original
|
| Description |
Financed by Research Project FONDECYT 11190300-Fondo Nacional de Desarrollo Cientifico y Tecnologico, ANID-Agencia Nacional de Investigacion y Desarrollo de Chile. Research Project DIUFRO [19-0065]-Direccion de Investigacion, Universidad de La Frontera.
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| doi |
10.3390/polym14030397
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| Formato Recurso |
PDF
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| Palabras Claves |
tissue engineering
nerve scaffold
morphology
peripheral nerve regeneration
regenerative biology
GLYCOLIC ACID) CONDUITS
SCHWANN-CELL BEHAVIOR
ELECTROSPUN FIBERS
IN-VITRO
BIOLOGICAL PERFORMANCE
NEURITE OUTGROWTH
GUIDE CONDUIT
FABRICATION
DIAMETER
ALIGNMENT
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| Ubicación del archivo | |
| Categoría OCDE |
Ciencia de los polímeros
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| Materias |
ingeniería de tejidos
andamio nervioso
morfología
regeneración de nervios periféricos
biología regenerativa
CONDUCTOS DE ÁCIDO GLICÓLICO
COMPORTAMIENTO DE LAS CÉLULAS DE SCHWANN
FIBRAS ELECTROhiladas
IN VITRO
RENDIMIENTO BIOLÓGICO
CRECIMIENTO DE NEURITAS
CONDUCTO GUÍA
FABRICACIÓN
DIÁMETRO
ALINEACIÓN
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| Título de la cita (Recomendado-único) |
Optimal Morphometric Characteristics of a Tubular Polymeric Scaffold to Promote Peripheral Nerve Regeneration: A Scoping Review
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 11190300
UFRO 19-0065
ANID FONDECYT 11190300
|
| Id de Web of Science |
WOS:000754976900001
|
cienciaabierta.ufro.cl
ciencia.abierta@ufrontera.cl