Repositorio UFRO · Omeka S

Optimal Morphometric Characteristics of a Tubular Polymeric Scaffold to Promote Peripheral Nerve Regeneration: A Scoping Review

Primer Autor	Dias, Fernando Jose
Co-autores	Alarcon Apablaza, Josefa Lezcano, Maria Florencia Godoy Sanchez, Karina Oporto, Gonzalo H.
Título	Optimal Morphometric Characteristics of a Tubular Polymeric Scaffold to Promote Peripheral Nerve Regeneration: A Scoping Review
Editorial	MDPI
Revista	POLYMERS
Lenguaje	en
Resumen	Cellular behavior in nerve regeneration is affected by the architecture of the polymeric nerve guide conduits (NGCs), therefore, design features of polymeric NGCs are critical for neural tissue engineering. Hence, the purpose of this scoping review is to summarize the adequate quantitative/morphometric parameters of the characteristics of NGC that provide a supportive environment for nerve regeneration, enhancing the understanding of a previous study. 394 studies were found, of which 29 studies were selected. The selected studies revealed four morphometric characteristics for promoting nerve regeneration: wall thickness, fiber size, pore size, and porosity. An NGC with a wall thickness between 250-400 mu m and porosity of 60-80%, with a small pore on the inner surface and a large pore on the outer surface, significantly favored nerve regeneration, resulting in an increase in nutrient permeability, retention of neurotrophic factors, and optimal mechanical properties. On the other hand, the superiority of electrospun fibers is described, however, the size of the fiber is controversial in the literature, obtaining optimal results in the range of 300 nm to 30 mu m. The incorporation of these optimal morphometric characteristics will encourage nerve regeneration and help reduce the number of experimental studies as it will provide the initial morphometric parameters for the preparation of an NGC.
Tipo de Recurso	artículo original
Description	Financed by Research Project FONDECYT 11190300-Fondo Nacional de Desarrollo Cientifico y Tecnologico, ANID-Agencia Nacional de Investigacion y Desarrollo de Chile. Research Project DIUFRO [19-0065]-Direccion de Investigacion, Universidad de La Frontera.
doi	10.3390/polym14030397
Formato Recurso	PDF
Palabras Claves	tissue engineering nerve scaffold morphology peripheral nerve regeneration regenerative biology GLYCOLIC ACID) CONDUITS SCHWANN-CELL BEHAVIOR ELECTROSPUN FIBERS IN-VITRO BIOLOGICAL PERFORMANCE NEURITE OUTGROWTH GUIDE CONDUIT FABRICATION DIAMETER ALIGNMENT
Ubicación del archivo	http://dx.doi.org/10.3390/polym14030397
Categoría OCDE	Ciencia de los polímeros
Materias	ingeniería de tejidos andamio nervioso morfología regeneración de nervios periféricos biología regenerativa CONDUCTOS DE ÁCIDO GLICÓLICO COMPORTAMIENTO DE LAS CÉLULAS DE SCHWANN FIBRAS ELECTROhiladas IN VITRO RENDIMIENTO BIOLÓGICO CRECIMIENTO DE NEURITAS CONDUCTO GUÍA FABRICACIÓN DIÁMETRO ALINEACIÓN
Disciplinas de la OCDE	Ingeniería Médica Biomateriales (Relacionados con implantes médicos, dispositivos y Sensores) Neurociencias
Título de la cita (Recomendado-único)	Optimal Morphometric Characteristics of a Tubular Polymeric Scaffold to Promote Peripheral Nerve Regeneration: A Scoping Review
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID-FONDECYT 11190300 UFRO 19-0065 ANID FONDECYT 11190300
Id de Web of Science	WOS:000754976900001