Effectiveness of Copper Nanoparticles in Wound Healing Process Using In Vivo and In Vitro Studies: A Systematic Review

Primer Autor
Sandoval, Cristian
Co-autores
Rios, Gemima
Sepulveda, Natalia
Salvo, Jessica
Souza-Mello, Vanessa
Farias, Jorge
Título
Effectiveness of Copper Nanoparticles in Wound Healing Process Using In Vivo and In Vitro Studies: A Systematic Review
Editorial
MDPI
Revista
PHARMACEUTICS
Lenguaje
en
Resumen
Chronic wounds are defined as wounds that do not heal in an orderly and timely manner through the various stages of the healing process. Copper nanoparticles are essential in dressings for wound healing because they promote angiogenesis and skin regeneration, which hasten the healing process. This systematic investigation sought to explain how copper nanoparticles affect chronic wound healing in vivo and in vitro. We realized a systematic review of original articles studying the effectiveness of copper nanoparticles in the healing process of chronic wounds. The protocol was registered in the PROSPERO database. Several databases were searched between 2012 and January 2022 for English-language papers using MeSH terms and text related to chronic wounds, copper nanoparticles, and wound healing. Quality was evaluated using National Institute for Health and Care Excellence methodology and PRISMA guidelines. We looked at a total of 12 primary studies. Quantitative data were gathered and presented in all studies. Our results suggest that copper nanoparticles could have an excellent healing property, facilitating the liberation of growth factors that help the anti-inflammatory process of the wound and significantly improving antibacterial and antioxidant activities. In addition, copper presents a higher biocompatibility than other metallic ions, promoting regeneration and increasing skin quality.
Tipo de Recurso
artículo de revisión
doi
10.3390/pharmaceutics14091838
Formato Recurso
PDF
Palabras Claves
angiogenesis
antimicrobial
regeneration
nanoparticles
MATRIX METALLOPROTEINASES
MECHANISMS
BACTERIA
POLYMER
EXPRESSION
EFFICACY
IMPACT
ZINC
Ubicación del archivo
http://dx.doi.org/10.3390/pharmaceutics14091838
Categoría OCDE
Farmacología y farmacia
Materias
angiogénesis
antimicrobiano
regeneración
nanopartículas
METALOPROTEINASAS DE MATRIZ
MECANISMOS
BACTERIAS
POLÍMERO
EXPRESIÓN
EFICACIA
IMPACTO
ZINC
Disciplinas de la OCDE
Ingeniería Médica
Nanomateriales (Producción y Propiedades)
Otros Temas de Medicina Básica
Título de la cita (Recomendado-único)
Effectiveness of Copper Nanoparticles in Wound Healing Process Using In Vivo and In Vitro Studies: A Systematic Review
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000858929000001
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Colección Publicaciones Científicas
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