Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity
| Primer Autor |
Salazar, Luis A.
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| Co-autores |
Guzman-Oyarzo, Dina
Hernandez-Montelongo, Jacobo
Rosas, Carlos
Leal, Pamela
Weber, Helga
Alvear, Marysol
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| Título |
Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity
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| Editorial |
MDPI
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| Revista |
PHARMACEUTICS
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| Lenguaje |
en
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| Resumen |
Although polyphenols have great pharmacological potential, the main disadvantage is that they have low bioavailability at the desired site. Thus, the use of biocompatible systems for drug delivery is a strategy that is currently gaining great interest. The objective of this study is to evaluate the effect of microencapsulation of caffeic acid and pinocembrin on the antioxidant and antiangiogenic activity of both polyphenols, by the use of nPSi-beta CD composite microparticles. For this HUVEC, cells were exposed to H2O2 and to treatments with polyphenols in solution and loaded in the composite microparticle. The polyphenols were incorporated into a microparticle using nanoporous silicon, chitosan and a beta-cyclodextrin polymer as the biomaterial. The evaluation of the antiangiogenic effect of the treatments with polyphenols in solution and microencapsulated was carried out through functional tests, and the changes in the expression of target genes associated with the antioxidant pathway and angiogenesis was performed through qPCR. The results obtained show that the caffeic acid and pinocembrin have an antioxidant and antiangiogenic activity, both in solution as microencapsulated. In the caffeic acid, a greater biological effect was observed when it was incorporated into the nPSi-beta CD composite microparticle. Our results suggest that the nPSi-beta CD composite microparticle could be used as an alternative oral drug administration system.
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| Tipo de Recurso |
artículo original
|
| Description |
This work was financially supported by the Fondo Nacional de Desarrollo Cientifico Tecnologico FONDECYT-Chile (Grant numbers 11180395 and 1171765) and CONICYT Scholarship (21140154).
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| doi |
10.3390/pharmaceutics14030484
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| Formato Recurso |
PDF
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| Palabras Claves |
antiangiogenic activity
caffeic acid
pinocembrin
polyphenols
HUVECs
controlled release
nPSi/beta CD microparticle
HYDROGEN-PEROXIDE
ANTIOXIDANT ACTIVITY
OXIDATIVE DAMAGE
PHENETHYL ESTER
GROWTH-FACTOR
NITRIC-OXIDE
CARBON DOTS
IN-VITRO
ANGIOGENESIS
NEOVASCULARIZATION
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| Ubicación del archivo | |
| Categoría OCDE |
Farmacología y farmacia
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| Materias |
actividad antiangiogénica
ácido cafeico
pinocembrina
polifenoles
HUVECs
liberación controlada
micropartícula nPSi/beta CD
PERÓXIDO DE HIDRÓGENO
ACTIVIDAD ANTIOXIDANTE
DAÑO OXIDATIVO
ÉSTER FENETÍLICO
FACTOR DE CRECIMIENTO
ÓXIDO NÍTRICO
PUNTOS DE CARBONO
IN VITRO
ANGIOGENESIS
NEOVASCULARIZACIÓN
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| Título de la cita (Recomendado-único) |
Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity
|
| Identificador del recurso (Mandatado-único) |
artículo original
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| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
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| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
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| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 11180395
ANID-FONDECYT 1171765
CONICYT 21140154
ANID FONDECYT 11180395
ANID FONDECYT 1171765
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| Id de Web of Science |
WOS:000776416000001
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