Repositorio UFRO · Omeka S

Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity

Primer Autor	Salazar, Luis A.
Co-autores	Guzman-Oyarzo, Dina Hernandez-Montelongo, Jacobo Rosas, Carlos Leal, Pamela Weber, Helga Alvear, Marysol
Título	Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity
Editorial	MDPI
Revista	PHARMACEUTICS
Lenguaje	en
Resumen	Although polyphenols have great pharmacological potential, the main disadvantage is that they have low bioavailability at the desired site. Thus, the use of biocompatible systems for drug delivery is a strategy that is currently gaining great interest. The objective of this study is to evaluate the effect of microencapsulation of caffeic acid and pinocembrin on the antioxidant and antiangiogenic activity of both polyphenols, by the use of nPSi-beta CD composite microparticles. For this HUVEC, cells were exposed to H2O2 and to treatments with polyphenols in solution and loaded in the composite microparticle. The polyphenols were incorporated into a microparticle using nanoporous silicon, chitosan and a beta-cyclodextrin polymer as the biomaterial. The evaluation of the antiangiogenic effect of the treatments with polyphenols in solution and microencapsulated was carried out through functional tests, and the changes in the expression of target genes associated with the antioxidant pathway and angiogenesis was performed through qPCR. The results obtained show that the caffeic acid and pinocembrin have an antioxidant and antiangiogenic activity, both in solution as microencapsulated. In the caffeic acid, a greater biological effect was observed when it was incorporated into the nPSi-beta CD composite microparticle. Our results suggest that the nPSi-beta CD composite microparticle could be used as an alternative oral drug administration system.
Tipo de Recurso	artículo original
Description	This work was financially supported by the Fondo Nacional de Desarrollo Cientifico Tecnologico FONDECYT-Chile (Grant numbers 11180395 and 1171765) and CONICYT Scholarship (21140154).
doi	10.3390/pharmaceutics14030484
Formato Recurso	PDF
Palabras Claves	antiangiogenic activity caffeic acid pinocembrin polyphenols HUVECs controlled release nPSi/beta CD microparticle HYDROGEN-PEROXIDE ANTIOXIDANT ACTIVITY OXIDATIVE DAMAGE PHENETHYL ESTER GROWTH-FACTOR NITRIC-OXIDE CARBON DOTS IN-VITRO ANGIOGENESIS NEOVASCULARIZATION
Ubicación del archivo	http://dx.doi.org/10.3390/pharmaceutics14030484
Categoría OCDE	Farmacología y farmacia
Materias	actividad antiangiogénica ácido cafeico pinocembrina polifenoles HUVECs liberación controlada micropartícula nPSi/beta CD PERÓXIDO DE HIDRÓGENO ACTIVIDAD ANTIOXIDANTE DAÑO OXIDATIVO ÉSTER FENETÍLICO FACTOR DE CRECIMIENTO ÓXIDO NÍTRICO PUNTOS DE CARBONO IN VITRO ANGIOGENESIS NEOVASCULARIZACIÓN
Disciplinas de la OCDE	Farmacología y Farmacia Biotecnología Relacionada con la Salud Nanomateriales (Producción y Propiedades)
Título de la cita (Recomendado-único)	Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID-FONDECYT 11180395 ANID-FONDECYT 1171765 CONICYT 21140154 ANID FONDECYT 11180395 ANID FONDECYT 1171765
Id de Web of Science	WOS:000776416000001