Repositorio
Institucional

Acevedo, Francisca

Hermosilla, Jeyson

Pastene-Navarrete, Edgar

Electrospun Fibers Loaded with Natural Bioactive Compounds as a Biomedical System for Skin Burn Treatment. A Review

MDPI

PHARMACEUTICS

en

Burns are a major threat to public health and the economy due to their costly and laborious treatment and high susceptibility to infection. Efforts have been made recently to investigate natural bioactive compounds with potential use in wound healing. The importance lies in the capacities that these compounds could possess both in infection control by common and resistant microorganisms, as well as in the regeneration of the affected tissues, having in both cases low adverse effects. However, some bioactive molecules are chemically unstable, poorly soluble, and susceptible to oxidative degradation or have low bioavailability. Therefore, developing new technologies for an efficient treatment of wound healing poses a real challenge. In this context, electrospun nanofibers have gained increasing research interest because bioactive molecules can be easily loaded within the nanofiber, resulting in optimal burst control and enhanced drug stability. Additionally, the nanofibers can mimic the extracellular collagen matrix, providing a suitable highly porous structural support for growing cells that facilitate and accelerate skin burns healing. This review gives an overview of the current state of electrospun fibers loaded with natural bioactive compounds as a biomedical system for skin burn treatment.

artículo de revisión

This research was funded by Agencia Nacional de Investigacion y Desarrollo of Chile (ANID) No21190396 National Doctorate Scholarship, DIUFRO projects DI22-0012 and DI18-0087.

10.3390/pharmaceutics13122054

PDF

antimicrobial agents

electrospinning

wound healing

biomaterials

NANOFIBROUS MEMBRANES

NANO-ENCAPSULATION

SUSTAINED-RELEASE

ASTRAGALOSIDE IV

ESSENTIAL OIL

STEM-CELLS

ANTIBACTERIAL

DELIVERY

COLLAGEN

FABRICATION

Farmacología y farmacia

agentes antimicrobianos

electrospinning

curación de heridas

biomateriales

MEMBRANAS NANOFIBRosas

NANOENCAPSULACIÓN

LIBERACIÓN SOSTENIDA

ASTRAGALOSIDO IV

ACEITE ESENCIAL

CÉLULAS MADRE

ANTIBACTERIAL

ENTREGA

COLÁGENO

FABRICACIÓN

Ingeniería Médica

Biotecnología Relacionada con la Salud

Biomateriales (Relacionados con implantes médicos, dispositivos y Sensores)

Electrospun Fibers Loaded with Natural Bioactive Compounds as a Biomedical System for Skin Burn Treatment. A Review

artículo de revisión

version publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

ANID-FONDECYT 21190396

Universidad de La Frontera DI22-0012

Universidad de La Frontera DI18-0087

ANID FONDECYT 21190396

WOS:000736693500001