Electrospun Fibers Loaded with Natural Bioactive Compounds as a Biomedical System for Skin Burn Treatment. A Review

Primer Autor
Acevedo, Francisca
Co-autores
Hermosilla, Jeyson
Pastene-Navarrete, Edgar
Título
Electrospun Fibers Loaded with Natural Bioactive Compounds as a Biomedical System for Skin Burn Treatment. A Review
Editorial
MDPI
Revista
PHARMACEUTICS
Lenguaje
en
Resumen
Burns are a major threat to public health and the economy due to their costly and laborious treatment and high susceptibility to infection. Efforts have been made recently to investigate natural bioactive compounds with potential use in wound healing. The importance lies in the capacities that these compounds could possess both in infection control by common and resistant microorganisms, as well as in the regeneration of the affected tissues, having in both cases low adverse effects. However, some bioactive molecules are chemically unstable, poorly soluble, and susceptible to oxidative degradation or have low bioavailability. Therefore, developing new technologies for an efficient treatment of wound healing poses a real challenge. In this context, electrospun nanofibers have gained increasing research interest because bioactive molecules can be easily loaded within the nanofiber, resulting in optimal burst control and enhanced drug stability. Additionally, the nanofibers can mimic the extracellular collagen matrix, providing a suitable highly porous structural support for growing cells that facilitate and accelerate skin burns healing. This review gives an overview of the current state of electrospun fibers loaded with natural bioactive compounds as a biomedical system for skin burn treatment.
Tipo de Recurso
artículo de revisión
Description
This research was funded by Agencia Nacional de Investigacion y Desarrollo of Chile (ANID) No21190396 National Doctorate Scholarship, DIUFRO projects DI22-0012 and DI18-0087.
doi
10.3390/pharmaceutics13122054
Formato Recurso
PDF
Palabras Claves
antimicrobial agents
electrospinning
wound healing
biomaterials
NANOFIBROUS MEMBRANES
NANO-ENCAPSULATION
SUSTAINED-RELEASE
ASTRAGALOSIDE IV
ESSENTIAL OIL
STEM-CELLS
ANTIBACTERIAL
DELIVERY
COLLAGEN
FABRICATION
Ubicación del archivo
http://dx.doi.org/10.3390/pharmaceutics13122054
Categoría OCDE
Farmacología y farmacia
Materias
agentes antimicrobianos
electrospinning
curación de heridas
biomateriales
MEMBRANAS NANOFIBRosas
NANOENCAPSULACIÓN
LIBERACIÓN SOSTENIDA
ASTRAGALOSIDO IV
ACEITE ESENCIAL
CÉLULAS MADRE
ANTIBACTERIAL
ENTREGA
COLÁGENO
FABRICACIÓN
Título de la cita (Recomendado-único)
Electrospun Fibers Loaded with Natural Bioactive Compounds as a Biomedical System for Skin Burn Treatment. A Review
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID-FONDECYT 21190396
Universidad de La Frontera DI22-0012
Universidad de La Frontera DI18-0087
ANID FONDECYT 21190396
Id de Web of Science
WOS:000736693500001
Colecciones
Colección Publicaciones Científicas
Colección ANID
Revisa las metricas alternativas de Almetrics
Revisa las citaciones de Dimensions