Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects

Primer Autor
Sureda, Antoni
Co-autores
Magdalena Quetglas-Llabres, Maria
Quispe, Cristina
Herrera-Bravo, Jesus
Catarino, Marcelo D.
Pereira, Olivia R.
Cardoso, Susana M.
Dua, Kamal
Chellappan, Dinesh Kumar
Pabreja, Kavita
Satija, Saurabh
Mehta, Meenu
Martorell, Miquel
Satmbekova, Dinara
Yeskaliyeva, Balakyz
Sharifi-Rad, Javad
Rasool, Naeem
Butnariu, Monica
Bagiu, Iulia Cristina
Bagiu, Radu Vasile
Calina, Daniela
Cho, William C.
Título
Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects
Editorial
HINDAWI LTD
Revista
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Lenguaje
en
Resumen
Bergapten (BP) or 5-methoxypsoralen (5-MOP) is a furocoumarin compound mainly found in bergamot essential oil but also in other citrus essential oils and grapefruit juice. This compound presents antibacterial, anti-inflammatory, hypolipemic, and anticancer effects and is successfully used as a photosensitizing agent. The present review focuses on the research evidence related to the therapeutic properties of bergapten collected in recent years. Many preclinical and in vitro studies have been evidenced the therapeutic action of BP, however, few clinical trials have been carried out to evaluate its efficacy. These clinical trials with BP are mainly focused on patients suffering from skin disorders such as psoriasis or vitiligo. In these trials, the administration of BP (oral or topical) combined with UV irradiation induces relevant lesion clearance rates. In addition, beneficial effects of bergamot extract were also observed in patients with altered serum lipid profiles and in people with nonalcoholic fatty liver. On the contrary, there are no clinical trials that investigate the possible effects on cancer. Although the bioavailability of BP is lower than that of its 8-methoxypsoralen (8-MOP) isomer, it has fewer side effects allowing higher concentrations to be administered. In conclusion, although the use of BP has therapeutic applications on skin disorders as a sensitizing agent and as components of bergamot extract as hypolipemic therapy, more trials are necessary to define the doses and treatment guidelines and its usefulness against other pathologies such as cancer or bacterial infections.
Tipo de Recurso
artículo de revisión
doi
10.1155/2022/8615242
Formato Recurso
PDF
Palabras Claves
CITRUS-BERGAMIA RISSO
5-METHOXYPSORALEN BERGAPTEN
ANTIMICROBIAL ACTIVITY
GENE-EXPRESSION
BIOAVAILABILITY
PHOTOTOXICITY
COUMARIN
EXTRACTS
PHOTOCHEMOTHERAPY
INFLAMMATION
Ubicación del archivo
http://dx.doi.org/10.1155/2022/8615242
Categoría OCDE
Biología Celular
Materias
CITRUS-BERGAMIA RISSO
5-METOXIPSORALEN BERGAPTEN
ACTIVIDAD ANTIMICROBIANA
EXPRESIÓN GENÉTICA
BIODISPONIBILIDAD
FOTOTOXICIDAD
CUMARINA
EXTRACTOS
FOTOQUIMIOTERAPIA
INFLAMACIÓN
Disciplinas de la OCDE
Farmacología y Farmacia
Dermatología y Enfermedades Venéreas
Química Orgánica
Título de la cita (Recomendado-único)
Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000795953300009
Colecciones
Colección Publicaciones Científicas
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