Repositorio
Institucional

Cruz-Martins, Natalia

Hossain, Rajib

Quispe, Cristina

Herrera-Bravo, Jesus

Islam, Md. Shahazul

Sarkar, Chandan

Islam, Muhammad Torequl

Martorell, Miquel

Al-Harrasi, Ahmed

Al-Rawahi, Ahmed

Sharifi-Rad, Javad

Ibrayeva, Manshuk

Dastan, Sevgi Durna

Alshehri, Mohammed M.

Calina, Daniela

Cho, William C.

Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review

HINDAWI LTD

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

2021

"Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, and Google Scholar using the keywords: ""Lasia spinosa,"" then combined with ""ethnopharmacological use,"" ""phytochemistry,"" and ""pharmacological activity."" This updated review included studies with in vitro, ex vivo, and in vivo experiments with compounds of known concentration and highlighted pharmacological mechanisms. The research results showed that L. spinosa contains many important nutritional and phytochemical components such as alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, and volatile oil with excellent bioactivity. The importance of this review lies in the fact that scientific pharmacological evidence supports the fact that the plant has antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic, antidiabetic, antihyperlipidemic, and antinociceptive effects, while protecting the gastrointestinal system and reproductive. Regarding future toxicological and safety data, more research is needed, including studies on human subjects. In light of these data, L. spinosa can be considered a medicinal plant with effective bioactives for the adjuvant treatment of various diseases in humans."

This work was supported by Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) PIA/APOYO CCTE AFB170007. N.C.-M. acknowledges the Portuguese Foundation for Science and Technology under the Horizon 2020 Program (PTDC/PSI-GER/28076/2017).

Este trabajo fue apoyado por la Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) PIA/APOYO CCTE AFB170007. N.C.-M. reconoce la Fundación Portuguesa para la Ciencia y la Tecnología en el marco del Programa Horizonte 2020 (PTDC/PSI-GER/28076/2017).

artículo de revisión

Farmacología y Farmacia

Química Médica

Botánica

verde

Biología Celular

Cruz-Martins, Natalia

Hossain, Rajib

WOS:000741727400002

CONICYT PIA/APOYO CCTE AFB170007

FCT PTDC/PSI-GER/28076/2017