Understanding autophagy role in cancer stem cell development

Primer Autor
Aguilar-Gallardo, Cristobal
Co-autores
Zamorano, Mauricio
Farias, Jorge G.
Quevedo, Karol De Aguiar
Título
Understanding autophagy role in cancer stem cell development
Editorial
SPRINGER
Revista
MOLECULAR BIOLOGY REPORTS
Lenguaje
en
Resumen
Cancer stem cells (CSCs) are a small subpopulation of immature cells located in the tumor mass. These cells are responsible for tumor development, proliferation, resistance and spreading. CSCs are characterized by three unique features: the ability to self-renew, differentiation and tumor formation. CSCs are similar to stem cells, but they differ in the malignant phenotype. CSCs become immortal and survive harsh environmental conditions such as hypoxia, starvation and oxidative stress. However, this harsh tumor microenvironment induces the activation of autophagy, which further increases the CSCs stemness profile, and all these features further increase tumorigenicity and metastasis capacity. Autophagy is induced by the extracellular and cellular microenvironment. Hypoxia is one of the most common factors that highly increases the activity of autophagy in CSCs. Therefore, hypoxia-induced autophagy and CSCs proliferation should be elucidated in order to find a novel cure to defeat cancer cells (CSCs and non-CSCs). The remaining challenges to close the gap between the laboratory bench and the development of therapies, to use autophagy against CSCs in patients, could be addressed by adopting a 3D platform to better-mimic the natural environment in which these cells reside. Ultimately allowing to obtain the blueprints for bioprocess scaling up and to develop the production pipeline for safe and cost-effective autophagy-based novel biologics.
Tipo de Recurso
artículo de revisión
doi
10.1007/s11033-022-07299-z
Formato Recurso
PDF
Palabras Claves
CSCs
Cancer Stem cells
Autophagy
Hypoxia
Signaling pathway
Hypoxia-targeted therapies
EPITHELIAL-MESENCHYMAL TRANSITION
CATENIN SIGNALING PATHWAY
BREAST-CANCER
BETA-CATENIN
DRUG-RESISTANCE
SELF-RENEWAL
HYPOXIA
NOTCH
HEDGEHOG
GROWTH
Ubicación del archivo
http://dx.doi.org/10.1007/s11033-022-07299-z
Categoría OCDE
Bioquímica y biología molecular
Materias
CSC
Células madre cancerosas
Autofagia
Hipoxia
Vía de señalización
Terapias dirigidas a la hipoxia
TRANSICIÓN EPITELIAL-MESENQUIMAL
VÍA DE SEÑALIZACIÓN DE CATENINA
CÁNCER DE MAMA
BETA-CATENINA
RESISTENCIA A LOS MEDICAMENTOS
AUTORENOVACIÓN
HIPOXIA
NOTCH
ERIZO
CRECIMIENTO
Disciplinas de la OCDE
Biología Molecular
Biología Celular
Oncología
Título de la cita (Recomendado-único)
Understanding autophagy role in cancer stem cell development
Página de inicio (Recomendado-único)
6741
Página final (Recomendado-único)
6751
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
restringido
Access Rights
restringido
Id de Web of Science
WOS:000767694700006
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