Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
| Primer Autor |
Santos, Andres
|
| Co-autores |
Burgos, Felipe
Martinez-Urtaza, Jaime
Barrientos, Leticia
|
| Título |
Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
|
| Editorial |
MDPI
|
| Revista |
MICROORGANISMS
|
| Lenguaje |
en
|
| Resumen |
Antibiotic resistance genes (ARGs) are undergoing a remarkably rapid geographic expansion in various ecosystems, including pristine environments such as Antarctica. The study of ARGs and environmental resistance genes (ERGs) mechanisms could provide a better understanding of their origin, evolution, and dissemination in these pristine environments. Here, we describe the diversity of ARGs and ERGs and the importance of mobile genetic elements as a possible mechanism for the dissemination of resistance genes in Antarctica. We analyzed five soil metagenomes from Deception Island in Antarctica. Results showed that detected ARGs are associated with mechanisms such as antibiotic efflux, antibiotic inactivation, and target alteration. On the other hand, resistance to metals, surfactants, and aromatic hydrocarbons were the dominant ERGs. The taxonomy of ARGs showed that Pseudomonas, Psychrobacter, and Staphylococcus could be key taxa for studying antibiotic resistance and environmental resistance to stress in Deception Island. In addition, results showed that ARGs are mainly associated with phage-type mobile elements suggesting a potential role in their dissemination and prevalence. Finally, these results provide valuable information regarding the ARGs and ERGs in Deception Island including the potential contribution of mobile genetic elements to the spread of ARGs and ERGs in one of the least studied Antarctic ecosystems to date.
|
| Tipo de Recurso |
artículo original
|
| Description |
This research was funded by Fondecyt Regular Nffi 1210563, grants DI19-0079, and grant CONICYT-Doctorado Nacional-2017-21171392 for A.S.
Esta investigación fue financiada por Fondecyt Regular Nffi 1210563, becas DI19-0079, y beca CONICYT-Doctorado Nacional-2017-21171392 para A.S.
|
| doi |
10.3390/microorganisms10071432
|
| Formato Recurso |
PDF
|
| Palabras Claves |
Antarctic soils
phages
plasmids
pristine environments
SOUTH SHETLAND ISLANDS
ANTIBIOTIC-RESISTANCE
METAL RESISTANCE
ENVIRONMENTS
BACTERIA
ARGS
|
| Ubicación del archivo | |
| Categoría OCDE |
Microbiología
|
| Materias |
Suelos antárticos
fagos
plásmidos
ambientes prístinos
ISLAS SHETLAND DEL SUR
RESISTENCIA A LOS ANTIBIÓTICOS
RESISTENCIA A LOS METALES
AMBIENTE
BACTERIAS
ARGS
|
| Título de la cita (Recomendado-único) |
Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 1210563
UFRO DI19-0079
ANID 21171392
ANID FONDECYT 1210563
|
| Id de Web of Science |
WOS:000833847500001
|
cienciaabierta.ufro.cl
ciencia.abierta@ufrontera.cl