Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

Primer Autor
Witek, Lukasz
Co-autores
Almeida Grossi, Joao Ricardo
Parra, Marcelo
Benalcazar-Jalkh, Ernesto B.
Giovanini, Allan Fernando
Zielak, Joao Cesar
Sebstiani, Aline Monise
Gonzaga, Carla Castiglia
Coelho, Paulo G.
Deliberador, Tatiana Miranda
Título
Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants
Editorial
MEDICINA ORAL S L
Revista
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
Lenguaje
en
Resumen
Background: The aim of the present study was to evaluate the effect of different concentrations of growth hormone (GH) on endosteal implant's surface at the early stages of osseointegration. Material and Methods: Sixty tapered acid-etched titanium implants were divided into four groups: i) Collagen, used as a control group, and three experimental groups, where after collagen coating, GH was administered directly to the surface in varying concentrations: ii) 0.265 mg, iii) 0.53 mg, and iv) 1 mg. Implants were placed in an interpolated fashion in the anterior flange of C3, C4 or C5 of 15 sheep with minimum distance of 6 mm between implants. After 3-, 6-and 12-weeks of healing samples were harvested, histologically processed, qualitatively and quantitatively assessed for bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Results: Statistical analysis as a function of time in vivo and coating resulted in no significant differences for BIC and BAFO at any evaluation time point. Histological evaluation demonstrated similar osseointegration features for all groups with woven bone formation at 3 weeks and progressive replacement of woven for lamellar bone in close contact with the implant surface and within the implant's threads. Conclusions: A single local application of growth hormone to the surface of titanium implants did not yield improved implant osseointegration independent of healing time.
Tipo de Recurso
artículo original
doi
10.4317/medoral.25164
Formato Recurso
PDF
Palabras Claves
Growth hormone
osseointegration
low density bones
metallic implants
sheep
bone-to-implant contact
INITIAL BONE-FORMATION
DENTAL IMPLANTS
BIOMATERIAL
Ubicación del archivo
http://dx.doi.org/10.4317/medoral.25164
Categoría OCDE
Odontología
Cirugía Bucal y Medicina
Materias
Hormona de crecimiento
osteointegración
huesos de baja densidad
implantes metálicos
ovejas
contacto hueso-implante
FORMACIÓN ÓSEA INICIAL
IMPLANTES DENTALES
BIOMATERIAL
Disciplinas de la OCDE
Ingeniería Médica
Biomateriales (Relacionados con implantes médicos, dispositivos y Sensores)
Fisiología
Versión del recurso (Recomendado-único)
version publicada
Tipo de ruta
dorada
verde
Access Rights
acceso abierto
Derechos de acceso
acceso abierto
Id de Web of Science
WOS:000763637000010
Título de la cita (Recomendado-único)
Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants
Página de inicio (Recomendado-único)
E174
Página final (Recomendado-único)
E180
Identificador del recurso (Mandatado-único)
artículo original
Condición de la licencia (Recomendado-repetible)
0
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Colección Publicaciones Científicas
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