Repositorio
Institucional

Witek, Lukasz

Almeida Grossi, Joao Ricardo

Parra, Marcelo

Benalcazar-Jalkh, Ernesto B.

Giovanini, Allan Fernando

Zielak, Joao Cesar

Sebstiani, Aline Monise

Gonzaga, Carla Castiglia

Coelho, Paulo G.

Deliberador, Tatiana Miranda

Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

MEDICINA ORAL S L

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL

en

Background: The aim of the present study was to evaluate the effect of different concentrations of growth hormone (GH) on endosteal implant's surface at the early stages of osseointegration. Material and Methods: Sixty tapered acid-etched titanium implants were divided into four groups: i) Collagen, used as a control group, and three experimental groups, where after collagen coating, GH was administered directly to the surface in varying concentrations: ii) 0.265 mg, iii) 0.53 mg, and iv) 1 mg. Implants were placed in an interpolated fashion in the anterior flange of C3, C4 or C5 of 15 sheep with minimum distance of 6 mm between implants. After 3-, 6-and 12-weeks of healing samples were harvested, histologically processed, qualitatively and quantitatively assessed for bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Results: Statistical analysis as a function of time in vivo and coating resulted in no significant differences for BIC and BAFO at any evaluation time point. Histological evaluation demonstrated similar osseointegration features for all groups with woven bone formation at 3 weeks and progressive replacement of woven for lamellar bone in close contact with the implant surface and within the implant's threads. Conclusions: A single local application of growth hormone to the surface of titanium implants did not yield improved implant osseointegration independent of healing time.

artículo original

10.4317/medoral.25164

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Growth hormone

osseointegration

low density bones

metallic implants

sheep

bone-to-implant contact

INITIAL BONE-FORMATION

DENTAL IMPLANTS

BIOMATERIAL

Odontología

Cirugía Bucal y Medicina

Hormona de crecimiento

osteointegración

huesos de baja densidad

implantes metálicos

ovejas

contacto hueso-implante

FORMACIÓN ÓSEA INICIAL

IMPLANTES DENTALES

BIOMATERIAL

Ingeniería Médica

Biomateriales (Relacionados con implantes médicos, dispositivos y Sensores)

Fisiología

Effects of a local single dose administration of growth hormone on the osseointegration of titanium implants

E174

E180

artículo original

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WOS:000763637000010