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Cellular Immune Response in Patients Immunized with Three Vaccine Doses of Different Vaccination Schemes Authorized by the Chilean Ministry of Health in January 2022

Primer Autor	Tabilo Valenzuela, Paz Beatriz
Co-autores	Flores Balter, Gabriela Saint-Pierre Contreras, Gustavo Conei Valencia, Daniel Moreno Calderon, Catalina Bohle Venegas, Constanza Guajardo Rivera, Marcia Silva Ojeda, Francisco Vial Covarrubias, Maria Jesus
Título	Cellular Immune Response in Patients Immunized with Three Vaccine Doses of Different Vaccination Schemes Authorized by the Chilean Ministry of Health in January 2022
Editorial	MDPI
Revista	LIFE-BASEL
Lenguaje	en
Resumen	In December 2019, a case of atypical pneumonia was reported in Wuhan, China. It was named COVID-19 and caused by SARS-CoV-2. In a few months, scientific groups around the world developed vaccines to reduce the disease's severity. The objective was to evaluate the humoral and cellular immune response post immunization with three different vaccination schedules administered in Chile until January 2022. Sixty volunteers were recruited with a three-dose schedule, who had no history of infection nor close contact with a positive patient. IgG against the spike antigenic domain was detected, and the neutralization capacity against two groups of variants, Original/Alpha and Beta/Gamma, was also measured. Finally, the cellular response with interferon release was measured through IGRA. Results showed that there were significant differences in the neutralizing antibodies for the original and alpha variant when comparing three Comirnaty doses with Coronavac and Vaxzevria. A high number of reactive subjects against the different SARS-CoV-2 variants, alpha, gamma, and delta, were observed, with no significant differences between any of the three schemes, confirming the existence of a cellular immune response against SARS-CoV-2. In conclusion, the three vaccine schemes generated a cellular immune response in these volunteers.
Tipo de Recurso	artículo original
doi	10.3390/life12040534
Formato Recurso	PDF
Palabras Claves	SARS-CoV-2 COVID-19 vaccines cell-mediated immunity interferon-gamma release assays SARS-COV-2 BNT162B2 RISK
Ubicación del archivo	http://dx.doi.org/10.3390/life12040534
Categoría OCDE	Biología Microbiología
Materias	SARS-CoV-2 vacunas COVID-19 inmunidad mediada por células ensayos de liberación de interferón-gamma SARS-COV-2 BNT162B2 RISK
Disciplinas de la OCDE	Inmunología Virología Biotecnología Relacionada con la Salud
Versión del recurso (Recomendado-único)	version publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000786930600001
Título de la cita (Recomendado-único)	Cellular Immune Response in Patients Immunized with Three Vaccine Doses of Different Vaccination Schemes Authorized by the Chilean Ministry of Health in January 2022
Identificador del recurso (Mandatado-único)	artículo original
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0