Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
| Primer Autor |
Herrera-Bravo, Jesus
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| Co-autores |
Sharifi-Rad, Javad
Rapposelli, Simona
Sestito, Simona
Arancibia-Diaz, Alejandra
Salazar, Luis A.
Yeskaliyeva, Balakyz
Beyatli, Ahmet
Leyva-Gomez, Gerardo
Gonzalez-Contreras, Carlos
Gurer, Eda Sonmez
Martorell, Miquel
Calina, Daniela
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| Título |
Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
|
| Editorial |
MDPI
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| Revista |
JOURNAL OF PERSONALIZED MEDICINE
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| Lenguaje |
en
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| Resumen |
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence of A beta-amyloid peptide, Tau protein, oxidative stress, and an exacerbated neuro-inflammatory response. This review aims to offer an updated compendium of the most recent and promising advances in AD treatment through the administration of phytochemicals. The literature survey was carried out by electronic search in the following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, and Web of Science regarding published works that included molecular mechanisms and signaling pathways targeted by phytochemicals in various experimental models of Alzheimer's disease in vitro and in vivo. The results of the studies showed that the use of phytochemicals against AD has gained relevance due to their antioxidant, anti-neuroinflammatory, anti-amyloid, and anti-hyperphosphorylation properties of Tau protein. Some bioactive compounds from plants have been shown to have the ability to prevent and stop the progression of Alzheimer's.
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| Tipo de Recurso |
artículo de revisión
|
| Description |
M.M. wants to thank ANID CENTROS BASALES ACE210012.
M.M. quiere agradecer a ANID CENTROS BASALES ACE210012.
|
| doi |
10.3390/jpm12091515
|
| Formato Recurso |
PDF
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| Palabras Claves |
Alzheimer's disease
phytochemicals
neuroinflammation
oxidative damage
protein aggregation
molecular mechanisms
neuroprotective effects
AMYLOID-BETA PEPTIDE
CELL-DEATH
COGNITIVE IMPAIRMENT
CHLOROGENIC ACID
NEURODEGENERATIVE DISEASES
ANTIOXIDATIVE ACTIVITIES
FRUIT POLYPHENOLS
SH-SY5Y CELLS
DOUBLE-BLIND
INFLAMMATION
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| Ubicación del archivo | |
| Categoría OCDE |
Ciencias y Servicios de Atención Médica
Medicina general e interna
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| Materias |
Enfermedad de Alzheimer
fitoquímicos
neuroinflamación
daño oxidativo
agregación de proteínas
mecanismos moleculares
efectos neuroprotectores
PÉPTIDO AMILOIDE-BETA
MUERTE CELULAR
DETERIORO COGNITIVO
ÁCIDO CLOROGÉNICO
ENFERMEDADES NEURODEGENERATIVAS
ACTIVIDADES ANTIOXIDATIVAS
POLIFENOLES DE FRUTAS
CÉLULAS SH-SY5Y
DOBLE- CIEGO
INFLAMACIÓN
|
| Título de la cita (Recomendado-único) |
Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
|
| Identificador del recurso (Mandatado-único) |
artículo de revisión
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
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| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID ACE210012
|
| Id de Web of Science |
WOS:000856789100001
|
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