Repositorio UFRO · Omeka S

Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Primer Autor	Herrera-Bravo, Jesus
Co-autores	Sharifi-Rad, Javad Rapposelli, Simona Sestito, Simona Arancibia-Diaz, Alejandra Salazar, Luis A. Yeskaliyeva, Balakyz Beyatli, Ahmet Leyva-Gomez, Gerardo Gonzalez-Contreras, Carlos Gurer, Eda Sonmez Martorell, Miquel Calina, Daniela
Título	Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Editorial	MDPI
Revista	JOURNAL OF PERSONALIZED MEDICINE
Lenguaje	en
Resumen	Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence of A beta-amyloid peptide, Tau protein, oxidative stress, and an exacerbated neuro-inflammatory response. This review aims to offer an updated compendium of the most recent and promising advances in AD treatment through the administration of phytochemicals. The literature survey was carried out by electronic search in the following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, and Web of Science regarding published works that included molecular mechanisms and signaling pathways targeted by phytochemicals in various experimental models of Alzheimer's disease in vitro and in vivo. The results of the studies showed that the use of phytochemicals against AD has gained relevance due to their antioxidant, anti-neuroinflammatory, anti-amyloid, and anti-hyperphosphorylation properties of Tau protein. Some bioactive compounds from plants have been shown to have the ability to prevent and stop the progression of Alzheimer's.
Tipo de Recurso	artículo de revisión
Description	M.M. wants to thank ANID CENTROS BASALES ACE210012. M.M. quiere agradecer a ANID CENTROS BASALES ACE210012.
doi	10.3390/jpm12091515
Formato Recurso	PDF
Palabras Claves	Alzheimer's disease phytochemicals neuroinflammation oxidative damage protein aggregation molecular mechanisms neuroprotective effects AMYLOID-BETA PEPTIDE CELL-DEATH COGNITIVE IMPAIRMENT CHLOROGENIC ACID NEURODEGENERATIVE DISEASES ANTIOXIDATIVE ACTIVITIES FRUIT POLYPHENOLS SH-SY5Y CELLS DOUBLE-BLIND INFLAMMATION
Ubicación del archivo	http://dx.doi.org/10.3390/jpm12091515
Categoría OCDE	Ciencias y Servicios de Atención Médica Medicina general e interna
Materias	Enfermedad de Alzheimer fitoquímicos neuroinflamación daño oxidativo agregación de proteínas mecanismos moleculares efectos neuroprotectores PÉPTIDO AMILOIDE-BETA MUERTE CELULAR DETERIORO COGNITIVO ÁCIDO CLOROGÉNICO ENFERMEDADES NEURODEGENERATIVAS ACTIVIDADES ANTIOXIDATIVAS POLIFENOLES DE FRUTAS CÉLULAS SH-SY5Y DOBLE- CIEGO INFLAMACIÓN
Disciplinas de la OCDE	Neurociencias Biotecnología Relacionada con la Salud Farmacología y Farmacia
Título de la cita (Recomendado-único)	Multi-Target Mechanisms of Phytochemicals in Alzheimer's Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID ACE210012
Id de Web of Science	WOS:000856789100001