PROTEOMIC PROFILE OF ECHINOCOCCUS GRANULOSUS: A SYSTEMATIC REVIEW

Primer Autor
Manterola, Carlos
Co-autores
Garcia-Mendez, Nayely
Totomoch-Serra, Armando
Riffo-Campos, Angela L.
Brito-Carreon, Cesar A.
Título
PROTEOMIC PROFILE OF ECHINOCOCCUS GRANULOSUS: A SYSTEMATIC REVIEW
Editorial
ALLEN PRESS INC
Revista
JOURNAL OF PARASITOLOGY
Lenguaje
en
Resumen
Cystic echinococcosis is a zoonotic disease caused by the larval stage of Echinococcus granulosus. This affliction is an endemic worldwide condition that represents a neglected parasitic disease with important socioeconomic repercussions. Proteomic characterization of larval and adult stages of E. granulosus, as well as the association between expression profiles and host interactions, is relevant for a better understanding of parasite biology, and eventually for drug design and vaccine development. This study aimed to develop a synthesis of the evidence available related to proteomics of E. granulosus. A systematic review was carried out to collect data concerning the proteomics of E. granulosus, without language or host restriction, published between 1980 and 2019. A systematic search was carried out in the Trip Database, BIREME-BVS, SciELO, Web of Science, PubMed, EMBASE, SCOPUS, EBSCO host, and LILACS, using MeSH terms, free words, and Boolean connectors, and adapting strategies to each source of information. Additionally, a manual cross-reference search was performed. Variables studied were the year of publication, geographic origin of the study, number of samples, hosts, parasitic organs, proteomic techniques, and parasite proteins verified. Nine-hundred and thirty-six related articles were identified: 17 fulfilled selection criteria, including slightly more than 188 samples. Most articles were published between 2014 and 2019 (64.7%) and were from Brazil and China (35.3% each). In reference to confirmed hosts in the primary articles, cattle (41.2%) and humans (23.5%) were the most frequently reported. Concerning proteomic techniques applied in the primary articles, LC-MS/MS was the most used (41.1%), and 890 proteins were reported by the primary articles. As the results of our search suggest, the information related to E. granulosus proteomics is scarce, heterogeneous, and scattered throughout several articles that include a diversity of tissues, samples, intermediate hosts, and proteomic techniques. Consequently, the level of evidence generated by our search is type 4.
Tipo de Recurso
artículo de revisión
doi
10.1645/20-86
Formato Recurso
PDF
Palabras Claves
Echinococcus granulosus
Proteins
Liver
Proteomics
HUMAN CYSTIC ECHINOCOCCOSIS
EXCRETORY/SECRETORY PRODUCTS
PLASMINOGEN-BINDING
PROTEIN
IDENTIFICATION
INFECTION
REVEALS
LARVAL
FLUID
METACESTODE
Ubicación del archivo
http://dx.doi.org/10.1645/20-86
Categoría OCDE
parasitología
Materias
Echinococcus granulosus
Proteínas
Hígado
Proteómica
EQUINOCOCOSIS QUÍSTICA HUMANA
PRODUCTOS EXCRETORIOS/SECRETORIOS
UNIÓN DE PLASMINÓGENO
PROTEÍNA
IDENTIFICACIÓN
INFECCIÓN
REVELA
LARVAS
FLUIDO
METACESTODO
Disciplinas de la OCDE
Parasitología
Biología Molecular
Biotecnología Relacionada con la Salud
Título de la cita (Recomendado-único)
PROTEOMIC PROFILE OF ECHINOCOCCUS GRANULOSUS: A SYSTEMATIC REVIEW
Página de inicio (Recomendado-único)
64
Página final (Recomendado-único)
69
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
metadata
Access Rights
metadata
Id de Web of Science
WOS:000765310100008
Colecciones
Colección Publicaciones Científicas
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