Recent advances in the design of antimicrobial peptide conjugates

Primer Autor
Rangel-Yagui, Carlota O.
Co-autores
Silva, Amanda R. P.
Guimaraes, Marina S.
Rabelo, Jheniffer
Herrera Belen, Lisandra
Jose Perecin, Caio
Farias, Jorge G.
Santos, Joao H. P. M.
Título
Recent advances in the design of antimicrobial peptide conjugates
Editorial
ROYAL SOC CHEMISTRY
Revista
JOURNAL OF MATERIALS CHEMISTRY B
Lenguaje
en
Resumen
Antimicrobial peptides (AMPs) are ubiquitous host defense peptides characterized by their antibiotic activity and lower propensity for developing resistance compared to classic antibiotics. While several AMPs have shown activity against antibiotic-sensitive and even multi-drug resistant strains, some bottlenecks to further development and clinical applications are still present, for instance, low antimicrobial activity, instability under physiological conditions, systemic toxicity and the potential for compromising the innate host defense immunity. Conjugation to molecules such as proteins, synthetic polymers, small molecules and nanoparticles are strategies under investigation to boost the therapeutic efficacy of AMPs. This review focuses on the design and application of AMPs' conjugates. In silico tools for creating new AMPs and AMPs' conjugates and their clinical development are also discussed. Furthermore, key future considerations regarding the major achievements and challenges of AMPs' conjugates in the antimicrobial resistance context are presented as a take-home message.
Tipo de Recurso
artículo de revisión
doi
10.1039/d1tb02757c
Formato Recurso
PDF
Palabras Claves
CELL-PENETRATING PEPTIDES
HOST-DEFENSE PEPTIDES
IN-VITRO ACTIVITY
HUMAN LACTOFERRIN
ANTIBACTERIAL PEPTIDES
BIOFILM FORMATION
MOLECULAR-WEIGHT
DRUG
DELIVERY
NANOPARTICLES
Ubicación del archivo
http://dx.doi.org/10.1039/d1tb02757c
Categoría OCDE
Ciencia de Materiales
Biomateriales
Materias
PÉPTIDOS QUE PENETRAN LAS CÉLULAS
PÉPTIDOS DE DEFENSA DEL HUÉSPED
ACTIVIDAD IN VITRO
LACTOFERRINA HUMANA
PÉPTIDOS ANTIBACTERIANOS
FORMACIÓN DE BIOPELÍCULAS
PESO MOLECULAR
DROGA
ENTREGA
NANOPARTÍCULAS
Disciplinas de la OCDE
Microbiología
Biología Molecular
Biotecnología Relacionada con la Salud
Título de la cita (Recomendado-único)
Recent advances in the design of antimicrobial peptide conjugates
Página de inicio (Recomendado-único)
3587
Página final (Recomendado-único)
3600
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
restringido
Access Rights
restringido
Id de Web of Science
WOS:000766244700001
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