Repositorio UFRO · Omeka S

Penicillium digitatum, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient

Primer Autor	Iturrieta-Gonzalez, Isabel
Co-autores	Giacaman, Annesi Godoy-Martinez, Patricio Vega, Fernando Sepulveda, Marcela Santos, Cledir Toledo, Valentina Rivera, Gonzalo Ortega, Leandro San Martin, Andres Bahamondes, Vitalia Collao, Felipe Sanchez, Raul Fonseca-Salamanca, Flery
Título	Penicillium digitatum, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient
Editorial	MDPI
Revista	JOURNAL OF FUNGI
Lenguaje	en
Resumen	Penicillium digitatum is one of the most important phytopathogens. It causes deterioration and rotting of citrus fruits, generating significant economic losses worldwide. As a human pathogen, it is extremely rare. We present a case of pulmonary co-infection in a patient diagnosed with pneumonia due to SARS-CoV-2. A 20-year-old female patient, primigravid, 36 weeks of gestation, without comorbidities, and diagnosed with severe pneumonia due to the SARS-CoV-2, showed rapid lung deterioration for which their pregnancy was interrupted by surgery. The patient was hospitalized in the Intensive Care Unit (ICU), connected to mechanical ventilation and receiving corticosteroids and antibiotics. The diagnosis of pulmonary fungal infection was made through bronchoalveolar lavage (BAL) culture, and the species identification was performed by sequencing of beta-tubulin. Phylogenetic analysis with related species was performed for the confirmation of species identification. Antifungal susceptibility tests were performed for itraconazole (4 mu g/mL), voriconazole (2 mu g/mL), and amphotericin B (2 mu g/mL). The patient was successfully treated with itraconazole. This is the second worldwide report of pulmonary infection by P. digitatum and the first in Chile. Although it is a fungus that rarely infects humans, it could represent an emerging opportunistic fungal pathogen, with associated risk factors that should be considered in the differential diagnosis of Penicillium species isolated from infections in humans.
Tipo de Recurso	artículo original
doi	10.3390/jof8090961
Formato Recurso	PDF
Palabras Claves	Penicillium digitatum COVID-19 pulmonar infection pneumonia MULTIPLE SEQUENCE ALIGNMENT ASPERGILLUS INFECTION CITRININ
Ubicación del archivo	http://dx.doi.org/10.3390/jof8090961
Categoría OCDE	Microbiología Micología
Materias	Penicillium digitatum COVID-19 infección pulmonar neumonía ALINEACIÓN DE SECUENCIAS MÚLTIPLES ASPERGILLUS INFECCIÓN CITRININA
Disciplinas de la OCDE	Micología Microbiología Enfermedades Infecciosas
Título de la cita (Recomendado-único)	Penicillium digitatum, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000858301700001