Repositorio
Institucional

Iturrieta-Gonzalez, Isabel

Giacaman, Annesi

Godoy-Martinez, Patricio

Vega, Fernando

Sepulveda, Marcela

Santos, Cledir

Toledo, Valentina

Rivera, Gonzalo

Ortega, Leandro

San Martin, Andres

Bahamondes, Vitalia

Collao, Felipe

Sanchez, Raul

Fonseca-Salamanca, Flery

Penicillium digitatum, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient

MDPI

JOURNAL OF FUNGI

en

Penicillium digitatum is one of the most important phytopathogens. It causes deterioration and rotting of citrus fruits, generating significant economic losses worldwide. As a human pathogen, it is extremely rare. We present a case of pulmonary co-infection in a patient diagnosed with pneumonia due to SARS-CoV-2. A 20-year-old female patient, primigravid, 36 weeks of gestation, without comorbidities, and diagnosed with severe pneumonia due to the SARS-CoV-2, showed rapid lung deterioration for which their pregnancy was interrupted by surgery. The patient was hospitalized in the Intensive Care Unit (ICU), connected to mechanical ventilation and receiving corticosteroids and antibiotics. The diagnosis of pulmonary fungal infection was made through bronchoalveolar lavage (BAL) culture, and the species identification was performed by sequencing of beta-tubulin. Phylogenetic analysis with related species was performed for the confirmation of species identification. Antifungal susceptibility tests were performed for itraconazole (4 mu g/mL), voriconazole (2 mu g/mL), and amphotericin B (2 mu g/mL). The patient was successfully treated with itraconazole. This is the second worldwide report of pulmonary infection by P. digitatum and the first in Chile. Although it is a fungus that rarely infects humans, it could represent an emerging opportunistic fungal pathogen, with associated risk factors that should be considered in the differential diagnosis of Penicillium species isolated from infections in humans.

artículo original

10.3390/jof8090961

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Penicillium digitatum

COVID-19

pulmonar infection

pneumonia

MULTIPLE SEQUENCE ALIGNMENT

ASPERGILLUS

INFECTION

CITRININ

Microbiología

Micología

Penicillium digitatum

COVID-19

infección pulmonar

neumonía

ALINEACIÓN DE SECUENCIAS MÚLTIPLES

ASPERGILLUS

INFECCIÓN

CITRININA

Micología

Microbiología

Enfermedades Infecciosas

Penicillium digitatum, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient

artículo original

version publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:000858301700001