Repositorio
Institucional

Vergara, Daniela

Loza-Rodriguez, Noelia

Acevedo, Francisca

Bustamante, Mariela

Lopez, Olga

Povidone-iodine loaded bigels: Characterization and effect as a hand antiseptic agent

ELSEVIER

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

en

Hand hygiene has proven to be one of the most effective practices to prevent the spread of infectious microorganisms. Povidone-iodine (PVP-I) is one of the most effective antiseptics for this purpose. In this study, bigels (hybrid systems of oleogel and hydrogel) loaded with PVP-I were prepared varying the oleogel:hydrogel ratio 40:60 and 60:40 (called: BPVP-I O:H-40:60 and BPVP-I O:H-60:40 respectively). The oleogel was prepared with a base of extra virgin olive oil, beeswax, and alpha-tocopherol, the hydrogel was prepared with deionized water, hydroxyethylcellulose, and PVP-I at 5% (w/v). Bigels were characterized by visual appearance, microstructure, rheological behavior, and molecular ordering. Iodine (I-2) release from the bigels was analyzed through kinetic models. The antibacterial effectiveness was evaluated with the in vivo finger-streak technique on an agar surface, using ten volunteers for treatment. Results show that BPVP-I O:H-40:60 had a soft and smooth texture, while BPVP-I O:H-60:40 presented a harder and firmer texture. Microscopic studies showed an interconnected network of pores and the continuous phase formation of bigels for BPVP-I O:H-40:60 and hydrogel-in-oleogel type bigels for BPVP-I O: H-60:40. Structural differences altered the viscoelastic behavior of the bigels. Bigels with a higher hydrogel concentration (BPVP-I O:H-40:60) were less rigid, while bigels with a higher oleogel concentration (BPVP-I O:H-60:40) had the greatest resistance to deformation. The Weibull model equation best fitted the release data of I-2. I-2 release kinetic data showed a Fickian diffusion behavior. The antiseptic action of bigels reduces bacterial growth on the fingers 1 h after application. These results suggest that both bigels formulated can act as promising alternatives to hand antiseptic products.

artículo original

10.1016/j.jddst.2022.103427

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Povidone-iodine

Bigels

Antibacterial

Hand antiseptic

HYDROGEL

DELIVERY

ANTIBACTERIAL

RELEASE

HEALTH

OIL

Farmacología y farmacia

Povidona yodada

Bigels

Antibacteriano

Antiséptico de manos

HIDROGEL

ENTREGA

ANTIBACTERIAL

LIBERACIÓN

SALUD

ACEITE

Farmacología y Farmacia

Ingeniería Química

Microbiología

Povidone-iodine loaded bigels: Characterization and effect as a hand antiseptic agent

artículo original

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WOS:000805776700003