Povidone-iodine loaded bigels: Characterization and effect as a hand antiseptic agent

Primer Autor
Vergara, Daniela
Co-autores
Loza-Rodriguez, Noelia
Acevedo, Francisca
Bustamante, Mariela
Lopez, Olga
Título
Povidone-iodine loaded bigels: Characterization and effect as a hand antiseptic agent
Editorial
ELSEVIER
Revista
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Lenguaje
en
Resumen
Hand hygiene has proven to be one of the most effective practices to prevent the spread of infectious microorganisms. Povidone-iodine (PVP-I) is one of the most effective antiseptics for this purpose. In this study, bigels (hybrid systems of oleogel and hydrogel) loaded with PVP-I were prepared varying the oleogel:hydrogel ratio 40:60 and 60:40 (called: BPVP-I O:H-40:60 and BPVP-I O:H-60:40 respectively). The oleogel was prepared with a base of extra virgin olive oil, beeswax, and alpha-tocopherol, the hydrogel was prepared with deionized water, hydroxyethylcellulose, and PVP-I at 5% (w/v). Bigels were characterized by visual appearance, microstructure, rheological behavior, and molecular ordering. Iodine (I-2) release from the bigels was analyzed through kinetic models. The antibacterial effectiveness was evaluated with the in vivo finger-streak technique on an agar surface, using ten volunteers for treatment. Results show that BPVP-I O:H-40:60 had a soft and smooth texture, while BPVP-I O:H-60:40 presented a harder and firmer texture. Microscopic studies showed an interconnected network of pores and the continuous phase formation of bigels for BPVP-I O:H-40:60 and hydrogel-in-oleogel type bigels for BPVP-I O: H-60:40. Structural differences altered the viscoelastic behavior of the bigels. Bigels with a higher hydrogel concentration (BPVP-I O:H-40:60) were less rigid, while bigels with a higher oleogel concentration (BPVP-I O:H-60:40) had the greatest resistance to deformation. The Weibull model equation best fitted the release data of I-2. I-2 release kinetic data showed a Fickian diffusion behavior. The antiseptic action of bigels reduces bacterial growth on the fingers 1 h after application. These results suggest that both bigels formulated can act as promising alternatives to hand antiseptic products.
Tipo de Recurso
artículo original
doi
10.1016/j.jddst.2022.103427
Formato Recurso
PDF
Palabras Claves
Povidone-iodine
Bigels
Antibacterial
Hand antiseptic
HYDROGEL
DELIVERY
ANTIBACTERIAL
RELEASE
HEALTH
OIL
Ubicación del archivo
http://dx.doi.org/10.1016/j.jddst.2022.103427
Categoría OCDE
Farmacología y farmacia
Materias
Povidona yodada
Bigels
Antibacteriano
Antiséptico de manos
HIDROGEL
ENTREGA
ANTIBACTERIAL
LIBERACIÓN
SALUD
ACEITE
Disciplinas de la OCDE
Farmacología y Farmacia
Ingeniería Química
Microbiología
Título de la cita (Recomendado-único)
Povidone-iodine loaded bigels: Characterization and effect as a hand antiseptic agent
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
metadata
Access Rights
metadata
Id de Web of Science
WOS:000805776700003
Colecciones
Colección Publicaciones Científicas
Estadísticas del documento
0 visitas
Métricas externas
Altmetric
Dimensions