Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management

Primer Autor
Dominguez, Jose
Co-autores
Safont, Guillem
Latorre, Irene
Villar-Hernandez, Raquel
Stojanovic, Zoran
Marin, Alicia
Perez-Cano, Cristina
Lacoma, Alicia
Molina-Moya, Barbara
Jhunior Solis, Alan
Armestar, Fernando
Matllo, Joan
Diaz-Fernandez, Sergio
Cendon, Arnau
Sokalchuk, Liliya
Tolosa, Guillermo
Casas, Irma
Rosell, Antoni
Título
Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
Editorial
MDPI
Revista
JOURNAL OF CLINICAL MEDICINE
Lenguaje
en
Resumen
The measurement of specific T-cell responses can be a useful tool for COVID-19 diagnostics and clinical management. In this study, we evaluated the IFN-gamma T-cell response against the main SARS-CoV-2 antigens (spike, nucleocapsid and membrane) in acute and convalescent individuals classified according to severity, and in vaccinated and unvaccinated controls. IgG against spike and nucleocapsid were also measured. Spike antigen triggered the highest number of T-cell responses. Acute patients showed a low percentage of positive responses when compared to convalescent (71.6% vs. 91.7%, respectively), but increased during hospitalization and with severity. Some convalescent patients showed an IFN-gamma T-cell response more than 200 days after diagnosis. Only half of the vaccinated individuals displayed an IFN-gamma T-cell response after the second dose. IgG response was found in a higher percentage of individuals compared to IFN-gamma T-cell responses, and moderate correlations between both responses were seen. However, in some acute COVID-19 patients specific T-cell response was detected, but not IgG production. We found that the chances of an IFN-gamma T-cell response against SARS-CoV-2 is low during acute phase, but may increase over time, and that only half of the vaccinated individuals had an IFN-gamma T-cell response after the second dose.
Tipo de Recurso
artículo original
doi
10.3390/jcm11175103
Formato Recurso
PDF
Palabras Claves
SARS-CoV-2
T-cell response
humoral response
IFN-gamma
vaccination
ELISPOT
COVID-19
ANTIBODY
Ubicación del archivo
http://dx.doi.org/10.3390/jcm11175103
Categoría OCDE
Medicina general e interna
Materias
SARS-CoV-2
respuesta de células T
respuesta humoral
IFN-gamma
vacunación
ELISPOT
COVID-19
ANTICUERPO
Disciplinas de la OCDE
Inmunología
Virología
Biotecnología Relacionada con la Salud
Título de la cita (Recomendado-único)
Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000851155000001
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