Repositorio UFRO · Omeka S

Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management

Primer Autor	Dominguez, Jose
Co-autores	Safont, Guillem Latorre, Irene Villar-Hernandez, Raquel Stojanovic, Zoran Marin, Alicia Perez-Cano, Cristina Lacoma, Alicia Molina-Moya, Barbara Jhunior Solis, Alan Armestar, Fernando Matllo, Joan Diaz-Fernandez, Sergio Cendon, Arnau Sokalchuk, Liliya Tolosa, Guillermo Casas, Irma Rosell, Antoni
Título	Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
Editorial	MDPI
Revista	JOURNAL OF CLINICAL MEDICINE
Lenguaje	en
Resumen	The measurement of specific T-cell responses can be a useful tool for COVID-19 diagnostics and clinical management. In this study, we evaluated the IFN-gamma T-cell response against the main SARS-CoV-2 antigens (spike, nucleocapsid and membrane) in acute and convalescent individuals classified according to severity, and in vaccinated and unvaccinated controls. IgG against spike and nucleocapsid were also measured. Spike antigen triggered the highest number of T-cell responses. Acute patients showed a low percentage of positive responses when compared to convalescent (71.6% vs. 91.7%, respectively), but increased during hospitalization and with severity. Some convalescent patients showed an IFN-gamma T-cell response more than 200 days after diagnosis. Only half of the vaccinated individuals displayed an IFN-gamma T-cell response after the second dose. IgG response was found in a higher percentage of individuals compared to IFN-gamma T-cell responses, and moderate correlations between both responses were seen. However, in some acute COVID-19 patients specific T-cell response was detected, but not IgG production. We found that the chances of an IFN-gamma T-cell response against SARS-CoV-2 is low during acute phase, but may increase over time, and that only half of the vaccinated individuals had an IFN-gamma T-cell response after the second dose.
Tipo de Recurso	artículo original
doi	10.3390/jcm11175103
Formato Recurso	PDF
Palabras Claves	SARS-CoV-2 T-cell response humoral response IFN-gamma vaccination ELISPOT COVID-19 ANTIBODY
Ubicación del archivo	http://dx.doi.org/10.3390/jcm11175103
Categoría OCDE	Medicina general e interna
Materias	SARS-CoV-2 respuesta de células T respuesta humoral IFN-gamma vacunación ELISPOT COVID-19 ANTICUERPO
Disciplinas de la OCDE	Inmunología Virología Biotecnología Relacionada con la Salud
Título de la cita (Recomendado-único)	Measuring T-Cell Responses against SARS-CoV-2 Is of Utility for Disease and Vaccination Management
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000851155000001