Repositorio
Institucional

Dias, Fernando Jose

Arias-Betancur, Alain

Badilla-Wenzel, Nicolas

Astete-Sanhueza, Alvaro

Farfan-Beltran, Nicole

Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration

ELSEVIER SCI LTD

JAPANESE DENTAL SCIENCE REVIEW

en

Different types of biomaterials have been used to fabricate carriers to deliver bone morphogenetic proteins (BMPs) in both dentoalveolar and maxillofacial bone regeneration procedures. Despite that absorbable collagen sponge (ACS) is considered the gold standard for BMP delivery, there is still some concerns re-garding its use mainly due to its poor mechanical properties. To overcome this, novel systems are being developed, however, due to the wide variety of biomaterial combination, the heterogeneous assessment of newly formed tissue, and the intended clinical applications, there is still no consensus regarding which is more efficient in a particular clinical scenario. The combination of two or more biomaterials in different topological configurations has allowed specific controlled-release patterns for BMPs, improving their bio-logical and mechanical properties compared with classical single-material carriers. However, more basic research is needed. Since the BMPs can be used in multiple clinical scenarios having different biological and mechanical needs, novel carriers should be developed in a context-specific manner. Thus, the purpose of this review is to gather current knowledge about biomaterials used to fabricate delivery systems for BMPs in both dentoalveolar and maxillofacial contexts. Aspects related with the biological, physical and mechanical characteristics of each biomaterial are also presented and discussed.(c) 2022Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

artículo de revisión

Acknowledgments This work was supported by the Research Office of Universidad de La Frontera, Chile (project number IAF18-0015) ; A.A-B thanks to CONICYT - PFCHA/Mag?ster Nacional/2017 - folio no. 22171876 (Chile) ..

Agradecimientos Este trabajo fue apoyado por la Oficina de Investigación de la Universidad de La Frontera, Chile (número de proyecto IAF18-0015); A.A-B agradecimiento a CONICYT - PFCHA/Magíster Nacional/2017 - folio no. 22171876 (Chile)

10.1016/j.jdsr.2022.10.001

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Bone regeneration

Dentoalveolar bone regeneration

Maxillofacial bone regeneration

Bone morphogenetic protein

Growth factors

Carriers

BIPHASIC CALCIUM-PHOSPHATE

PROTEIN-2-INDUCED PERIODONTAL REGENERATION

FACTOR-BETA SUPERFAMILY

ESCHERICHIA-COLI

ALVEOLAR BONE

GROWTH-FACTOR

POROUS HYDROXYAPATITE

RIDGE AUGMENTATION

COLLAGEN SPONGE

DELIVERY-SYSTEM

Odontología

Cirugía Bucal y Medicina

Regeneración ósea

Regeneración ósea dentoalveolar

Regeneración ósea maxilofacial

Proteína morfogenética ósea

Factores de crecimiento

Portadores

FOSFATO DE CALCIO BIFÁSICO

REGENERACIÓN PERIODONTAL INDUCIDA POR PROTEÍNA-2

SUPERFAMILIA FACTOR-BETA

ESCHERICHIA-COLI

HUESO ALVEOLAR

FACTOR DE CRECIMIENTO

POROSO HIDROXIAPATITA

AUMENTO DE CRESTA

ESPONJA DE COLÁGENO

SISTEMA DE ENTREGA

Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration

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artículo de revisión

version publicada

CC BY-NC-ND 4.0

CC BY-NC-ND 4.0

acceso abierto

acceso abierto

CONICYT 22171876

UFRO IAF18-0015

WOS:000875816200002