Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease
| Primer Autor |
Paz, Cristian
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| Co-autores |
Villegas, Cecilia
Perez, Rebeca
Petiz, Lyvia Lintzmaier
Glaser, Talita
Ulrich, Henning
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| Título |
Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease
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| Editorial |
WILEY
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| Revista |
IUBMB LIFE
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| Lenguaje |
en
|
| Resumen |
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual deterioration of cognitive function, memory, and inability to perform daily, social, or occupational activities. Its etiology is associated with the accumulation of beta-amyloid peptides, phosphorylated tau protein, and neuroinflammatory and oxidative processes in the brain. Currently, there is no successful pharmacological treatment for AD. The few approved drugs are mainly aimed at treating the symptoms, however, due to the increasing discovery of etiopathological factors, there are great efforts to find new multifunctional molecules to slow down the course of this neurodegenerative disease. The commercial Ginkgo biloba formulation EGb 761 (R) and Huperzine A, an alkaloid present in the plant Huperzia serrata, have shown in clinical trials to possess cholinergic and neuroprotective activities, including improvement in cognition, activities of daily living, and neuropsychiatric symptoms in AD patients. The purpose of this review is to expose the positive results of intervention with EGb 761 (R) and Huperzine in patients with mild to moderate AD in the last 10 years, highlighting the pharmacological functions that justify their use in AD therapy.
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| Tipo de Recurso |
artículo original
|
| doi |
10.1002/iub.2613
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| Formato Recurso |
PDF
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| Palabras Claves |
Alzheimer's disease
clinical trials
complementary therapies
Ginkgolides
Huperzine A
EXTRACT EGB 761(R)
MILD COGNITIVE IMPAIRMENT
BILOBA-EXTRACT
AMYLOID-BETA
NEUROPSYCHIATRIC SYMPTOMS
CHOLINESTERASE-INHIBITORS
MITOCHONDRIAL-FUNCTION
DRUG-DEVELOPMENT
DOUBLE-BLIND
RAT-BRAIN
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| Ubicación del archivo | |
| Categoría OCDE |
Bioquímica y Biología Molecular
Biología Celular
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| Materias |
Enfermedad de Alzheimer
ensayos clínicos
terapias complementarias
Ginkgólidos
Huperzina A
EXTRACTO EGB 761(R)
DETERIORO COGNITIVO LEVE
EXTRACTO DE BILOBA
AMILOIDE-BETA
SÍNTOMAS NEUROPSIQUIÁTRICOS
INHIBIDORES DE LA COLINESTERASA
FUNCIÓN MITOCONDRIAL
DESARROLLO DE FÁRMACOS
DOBLE- CIEGO
CEREBRO DE RATA
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| Disciplinas de la OCDE |
Neurología Clínica
Neurociencias
Farmacología y Farmacia
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| Título de la cita (Recomendado-único) |
Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease
|
| Página de inicio (Recomendado-único) |
763
|
| Página final (Recomendado-único) |
779
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| Identificador del recurso (Mandatado-único) |
artículo original
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| Versión del recurso (Recomendado-único) |
version publicada
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| Condición de la licencia (Recomendado-repetible) |
0
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| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
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| Id de Web of Science |
WOS:000778074100001
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