Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease

Primer Autor
Paz, Cristian
Co-autores
Villegas, Cecilia
Perez, Rebeca
Petiz, Lyvia Lintzmaier
Glaser, Talita
Ulrich, Henning
Título
Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease
Editorial
WILEY
Revista
IUBMB LIFE
Lenguaje
en
Resumen
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual deterioration of cognitive function, memory, and inability to perform daily, social, or occupational activities. Its etiology is associated with the accumulation of beta-amyloid peptides, phosphorylated tau protein, and neuroinflammatory and oxidative processes in the brain. Currently, there is no successful pharmacological treatment for AD. The few approved drugs are mainly aimed at treating the symptoms, however, due to the increasing discovery of etiopathological factors, there are great efforts to find new multifunctional molecules to slow down the course of this neurodegenerative disease. The commercial Ginkgo biloba formulation EGb 761 (R) and Huperzine A, an alkaloid present in the plant Huperzia serrata, have shown in clinical trials to possess cholinergic and neuroprotective activities, including improvement in cognition, activities of daily living, and neuropsychiatric symptoms in AD patients. The purpose of this review is to expose the positive results of intervention with EGb 761 (R) and Huperzine in patients with mild to moderate AD in the last 10 years, highlighting the pharmacological functions that justify their use in AD therapy.
Tipo de Recurso
artículo original
doi
10.1002/iub.2613
Formato Recurso
PDF
Palabras Claves
Alzheimer's disease
clinical trials
complementary therapies
Ginkgolides
Huperzine A
EXTRACT EGB 761(R)
MILD COGNITIVE IMPAIRMENT
BILOBA-EXTRACT
AMYLOID-BETA
NEUROPSYCHIATRIC SYMPTOMS
CHOLINESTERASE-INHIBITORS
MITOCHONDRIAL-FUNCTION
DRUG-DEVELOPMENT
DOUBLE-BLIND
RAT-BRAIN
Ubicación del archivo
http://dx.doi.org/10.1002/iub.2613
Categoría OCDE
Bioquímica y Biología Molecular
Biología Celular
Materias
Enfermedad de Alzheimer
ensayos clínicos
terapias complementarias
Ginkgólidos
Huperzina A
EXTRACTO EGB 761(R)
DETERIORO COGNITIVO LEVE
EXTRACTO DE BILOBA
AMILOIDE-BETA
SÍNTOMAS NEUROPSIQUIÁTRICOS
INHIBIDORES DE LA COLINESTERASA
FUNCIÓN MITOCONDRIAL
DESARROLLO DE FÁRMACOS
DOBLE- CIEGO
CEREBRO DE RATA
Disciplinas de la OCDE
Neurología Clínica
Neurociencias
Farmacología y Farmacia
Título de la cita (Recomendado-único)
Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease
Página de inicio (Recomendado-único)
763
Página final (Recomendado-único)
779
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000778074100001
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