Repositorio
Institucional

Figueiredo Deana, Naira

Alves, Nilton

Zaror, Carlos

del Sol, Mariano

Salvador Bagnato, Vanderlei

Effects of Laser Photobiomodulation on TGF-beta and VEGF Expression in Burn Wound: Systematic Review and Meta-Analysis in the Animal Model

SOC CHILENA ANATOMIA

INTERNATIONAL JOURNAL OF MORPHOLOGY

en

Laser photobiomodulation (laser PBM) is known to be able to accelerate burn wound healing in the animal model, however little evidence exists on the action of laser PBM on the expression of important proteins in wound healing in the animal model, such as VEGF and TGF-beta 1. The aim of this study was to carry out a systematic review in order to analyse the effect of laser PBM on VEGF and TGF-beta expression during burn wound repair in the animal model. A systematic review was carried out of the EMBASE, PubMed/MEDLINE and LILACS databases. The studies included were preclinical studies that analysed the action of laser PBM on the expression of VEGF and TGF-beta (1, 2, 3) during burn wound repair in the animal model. The SYRCLE risk of bias tool was used. Random effect models were used to estimate the combined effect. Increased VEGF expression was observed with the use of laser PBM at 4.93 J/cm(2) per point in the first two weeks after induction of the burn wound, with greater size of effect in the second week (SDM = 5.72, 95% CI: 3.14 to 8.31, I-2 = 0 %, very low certainty of evidence). We also observed that the effect of laser PBM on TGF-beta 1 expression was greater than in the control in the first week (SDM =-0.45, 95% CI:-1.91 to 1.02, I-2 = 51 %, very low certainty of evidence), but diminished in the third week after induction of the lesion (SDM =-2.50, 95% CI: 3.98 to-1.01, I-2 = 0 %, very low certainty of evidence). Laser PBM has an effect on TGF-beta 1 and VEGF expression, promoting burn wound repair in the animal model.

artículo de revisión

10.4067/S0717-95022022000100194

PDF

Laser photobiomodulation

Burn wound

Animal model

VEGF

TGF-beta

THERAPY 660 NM

GROWTH-FACTOR

2ND-DEGREE

INGAP

ACTIVATION

MECHANISMS

Anatomía y Morfología

Fotobiomodulación láser

Quemadura

Modelo animal

VEGF

TGF-beta

TERAPIA 660 NM

FACTOR DE CRECIMIENTO

2DO GRADO

INGAP

ACTIVACIÓN

MECANISMOS

Biotecnología Relacionada con la Salud

Otros Temas de Medicina Básica

Fisiología

version publicada

dorada

verde

acceso abierto

acceso abierto

WOS:000770886000029

Effects of Laser Photobiomodulation on TGF-beta and VEGF Expression in Burn Wound: Systematic Review and Meta-Analysis in the Animal Model

194

203

artículo de revisión

CC BY-NC 4.0

CC BY-NC 4.0