Effects of Laser Photobiomodulation on TGF-beta and VEGF Expression in Burn Wound: Systematic Review and Meta-Analysis in the Animal Model

Primer Autor
Figueiredo Deana, Naira
Co-autores
Alves, Nilton
Zaror, Carlos
del Sol, Mariano
Salvador Bagnato, Vanderlei
Título
Effects of Laser Photobiomodulation on TGF-beta and VEGF Expression in Burn Wound: Systematic Review and Meta-Analysis in the Animal Model
Editorial
SOC CHILENA ANATOMIA
Revista
INTERNATIONAL JOURNAL OF MORPHOLOGY
Lenguaje
en
Resumen
Laser photobiomodulation (laser PBM) is known to be able to accelerate burn wound healing in the animal model, however little evidence exists on the action of laser PBM on the expression of important proteins in wound healing in the animal model, such as VEGF and TGF-beta 1. The aim of this study was to carry out a systematic review in order to analyse the effect of laser PBM on VEGF and TGF-beta expression during burn wound repair in the animal model. A systematic review was carried out of the EMBASE, PubMed/MEDLINE and LILACS databases. The studies included were preclinical studies that analysed the action of laser PBM on the expression of VEGF and TGF-beta (1, 2, 3) during burn wound repair in the animal model. The SYRCLE risk of bias tool was used. Random effect models were used to estimate the combined effect. Increased VEGF expression was observed with the use of laser PBM at 4.93 J/cm(2) per point in the first two weeks after induction of the burn wound, with greater size of effect in the second week (SDM = 5.72, 95% CI: 3.14 to 8.31, I-2 = 0 %, very low certainty of evidence). We also observed that the effect of laser PBM on TGF-beta 1 expression was greater than in the control in the first week (SDM =-0.45, 95% CI:-1.91 to 1.02, I-2 = 51 %, very low certainty of evidence), but diminished in the third week after induction of the lesion (SDM =-2.50, 95% CI: 3.98 to-1.01, I-2 = 0 %, very low certainty of evidence). Laser PBM has an effect on TGF-beta 1 and VEGF expression, promoting burn wound repair in the animal model.
Tipo de Recurso
artículo de revisión
doi
10.4067/S0717-95022022000100194
Formato Recurso
PDF
Palabras Claves
Laser photobiomodulation
Burn wound
Animal model
VEGF
TGF-beta
THERAPY 660 NM
GROWTH-FACTOR
2ND-DEGREE
INGAP
ACTIVATION
MECHANISMS
Ubicación del archivo
http://dx.doi.org/10.4067/S0717-95022022000100194
Categoría OCDE
Anatomía y Morfología
Materias
Fotobiomodulación láser
Quemadura
Modelo animal
VEGF
TGF-beta
TERAPIA 660 NM
FACTOR DE CRECIMIENTO
2DO GRADO
INGAP
ACTIVACIÓN
MECANISMOS
Disciplinas de la OCDE
Biotecnología Relacionada con la Salud
Otros Temas de Medicina Básica
Fisiología
Título de la cita (Recomendado-único)
Effects of Laser Photobiomodulation on TGF-beta and VEGF Expression in Burn Wound: Systematic Review and Meta-Analysis in the Animal Model
Página de inicio (Recomendado-único)
194
Página final (Recomendado-único)
203
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY-NC 4.0
Condición de la licencia (Recomendado-repetible)
CC BY-NC 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000770886000029
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