Molecular Biomarkers in Peri-Implant Health and Disease: A Cross-Sectional Pilot Study
| Primer Autor |
Beltran, Victor,
|
| Co-autores |
Chaparro, Alejandra
Betancur, Daniel
Sam, Ye-Han
Moaven, Haniyeh
Tarjomani, Ali
Donos, Nikolaos
Sousa, Vanessa
|
| Título |
Molecular Biomarkers in Peri-Implant Health and Disease: A Cross-Sectional Pilot Study
|
| Editorial |
MDPI
|
| Revista |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
| Lenguaje |
en
|
| Resumen |
Background: The aim of this feasibility study was to investigate the concentration level of CCL-20/MIP-3 alpha, BAFF/BLyS, IL-23, RANKL, and Osteoprotegerin in the Peri-Implant Crevicular Fluid (PICF), from patients diagnosed with peri-implant mucositis and peri-implantitis, and to compare them with PICF from patients with healthy implants. Methods: Participants with at least one dental implant with healthy peri-implant tissues, peri-implant mucositis, or peri-implantitis were included. PICF was collected using paper strips from healthy and diseased peri-implant sites (n = 19). Biomarker levels were analyzed using a custom Multiplex ELISA Assay Kit. Results: In comparison to peri-implant health, the peri-implant mucositis group showed an increased concentration of CCL-20 MIP-3 alpha, BAFF/BLyS, IL-23, RANKL, and Osteoprotegerin. The peri-implantitis group had the lowest median concentration of Osteoprotegerin (1963 ng/mL), this group had a similar concentration of RANKL (640.84 ng/mL) when compared to the peri-implant health group. BAFF/BLyS (17.06 ng/mL) showed the highest concentration in the peri-implantitis group. Conclusions: This feasibility study suggests that IL-23 and RANKL may help to elucidate the pathogenesis during the conversion from peri-implant health to peri-implantitis. Further research is required in BAFF/BLyS for the early diagnosis of peri-implantitis.
|
| Tipo de Recurso |
artículo original
|
| Description |
This research was funded by National Agency for Research and Development of Chile (ANID), Project No. REDI170658. D.B. was supported by the School of Dentistry, Universidad de Concepcion, Concepcion, Chile. V.S. was supported by the National Institute for Health Research of the United Kingdom.
Esta investigación fue financiada por la Agencia Nacional de Investigación y Desarrollo de Chile (ANID), Proyecto No. REDI170658. D. B. Fue apoyado por la Facultad de Odontología de la Universidad de Concepción, Concepción, Chile. V.S. Fue apoyado por el Instituto Nacional de Investigación en Salud del Reino Unido.
|
| doi |
10.3390/ijms23179802
|
| Formato Recurso |
PDF
|
| Palabras Claves |
peri-implantitis
CCL-20/MIP-3 alpha
BAFF/BlyS
IL-23
RANKL
Osteoprotegerin
OSTEOPROTEGERIN LIGAND
BONE LOSS
MUCOSITIS
PERIODONTITIS
ARTHRITIS
|
| Ubicación del archivo | |
| Categoría OCDE |
Bioquímica y Biología Molecular
Química
Multidisciplinar
|
| Materias |
periimplantitis
CCL-20/MIP-3 alfa
BAFF/BlyS
IL-23
RANKL
Osteoprotegerin
LIGANDO DE OSTEOPROTEGERINA
PÉRDIDA Ósea
MUCOSITIS
PERIODONTITIS
ARTRITIS
|
| Título de la cita (Recomendado-único) |
Molecular Biomarkers in Peri-Implant Health and Disease: A Cross-Sectional Pilot Study
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID REDI170658
|
| Id de Web of Science |
WOS:000851881100001
|
cienciaabierta.ufro.cl
ciencia.abierta@ufrontera.cl