Repositorio UFRO · Omeka S

Molecular Biomarkers in Peri-Implant Health and Disease: A Cross-Sectional Pilot Study

Primer Autor	Beltran, Victor,
Co-autores	Chaparro, Alejandra Betancur, Daniel Sam, Ye-Han Moaven, Haniyeh Tarjomani, Ali Donos, Nikolaos Sousa, Vanessa
Título	Molecular Biomarkers in Peri-Implant Health and Disease: A Cross-Sectional Pilot Study
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	Background: The aim of this feasibility study was to investigate the concentration level of CCL-20/MIP-3 alpha, BAFF/BLyS, IL-23, RANKL, and Osteoprotegerin in the Peri-Implant Crevicular Fluid (PICF), from patients diagnosed with peri-implant mucositis and peri-implantitis, and to compare them with PICF from patients with healthy implants. Methods: Participants with at least one dental implant with healthy peri-implant tissues, peri-implant mucositis, or peri-implantitis were included. PICF was collected using paper strips from healthy and diseased peri-implant sites (n = 19). Biomarker levels were analyzed using a custom Multiplex ELISA Assay Kit. Results: In comparison to peri-implant health, the peri-implant mucositis group showed an increased concentration of CCL-20 MIP-3 alpha, BAFF/BLyS, IL-23, RANKL, and Osteoprotegerin. The peri-implantitis group had the lowest median concentration of Osteoprotegerin (1963 ng/mL), this group had a similar concentration of RANKL (640.84 ng/mL) when compared to the peri-implant health group. BAFF/BLyS (17.06 ng/mL) showed the highest concentration in the peri-implantitis group. Conclusions: This feasibility study suggests that IL-23 and RANKL may help to elucidate the pathogenesis during the conversion from peri-implant health to peri-implantitis. Further research is required in BAFF/BLyS for the early diagnosis of peri-implantitis.
Tipo de Recurso	artículo original
Description	This research was funded by National Agency for Research and Development of Chile (ANID), Project No. REDI170658. D.B. was supported by the School of Dentistry, Universidad de Concepcion, Concepcion, Chile. V.S. was supported by the National Institute for Health Research of the United Kingdom. Esta investigación fue financiada por la Agencia Nacional de Investigación y Desarrollo de Chile (ANID), Proyecto No. REDI170658. D. B. Fue apoyado por la Facultad de Odontología de la Universidad de Concepción, Concepción, Chile. V.S. Fue apoyado por el Instituto Nacional de Investigación en Salud del Reino Unido.
doi	10.3390/ijms23179802
Formato Recurso	PDF
Palabras Claves	peri-implantitis CCL-20/MIP-3 alpha BAFF/BlyS IL-23 RANKL Osteoprotegerin OSTEOPROTEGERIN LIGAND BONE LOSS MUCOSITIS PERIODONTITIS ARTHRITIS
Ubicación del archivo	http://dx.doi.org/10.3390/ijms23179802
Categoría OCDE	Bioquímica y Biología Molecular Química Multidisciplinar
Materias	periimplantitis CCL-20/MIP-3 alfa BAFF/BlyS IL-23 RANKL Osteoprotegerin LIGANDO DE OSTEOPROTEGERINA PÉRDIDA Ósea MUCOSITIS PERIODONTITIS ARTRITIS
Disciplinas de la OCDE	Odontología, Cirugía y Medicina Oral Inmunología Biotecnología Relacionada con la Salud
Título de la cita (Recomendado-único)	Molecular Biomarkers in Peri-Implant Health and Disease: A Cross-Sectional Pilot Study
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID REDI170658
Id de Web of Science	WOS:000851881100001