Biofluid Specificity of Long Non-Coding RNA Profile in Hypertension: Relevance of Exosomal Fraction

Primer Autor
Cortes, Raquel
Co-autores
Riffo-Campos, Angela L.
Perez-Hernandez, Javier
Martinez-Arroyo, Olga
Ortega, Ana
Flores-Chova, Ana
Redon, Josep
Título
Biofluid Specificity of Long Non-Coding RNA Profile in Hypertension: Relevance of Exosomal Fraction
Editorial
MDPI
Revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje
en
Resumen
Non-coding RNA (ncRNA)-mediated targeting of various genes regulates the molecular mechanisms of the pathogenesis of hypertension (HTN). However, very few circulating long ncRNAs (lncRNAs) have been reported to be altered in essential HTN. The aim of our study was to identify a lncRNA profile in plasma and plasma exosomes associated with urinary albumin excretion in HTN by next-generation sequencing and to assess biological functions enriched in response to albuminuria using GO and KEGG analysis. Plasma exosomes showed higher diversity and fold change of lncRNAs than plasma, and low transcript overlapping was found between the two biofluids. Enrichment analysis identified different biological pathways regulated in plasma or exosome fraction, which were implicated in fatty acid metabolism, extracellular matrix, and mechanisms of sorting ncRNAs into exosomes, while plasma pathways were implicated in genome reorganization, interference with RNA polymerase, and as scaffolds for assembling transcriptional regulators. Our study found a biofluid specific lncRNA profile associated with albuminuria, with higher diversity in exosomal fraction, which identifies several potential targets that may be utilized to study mechanisms of albuminuria and cardiovascular damage.
Tipo de Recurso
artículo original
doi
10.3390/ijms23095199
Formato Recurso
PDF
Palabras Claves
hypertension
urinary albumin excretion
long non-coding RNA
exosomes
PLASMA
IDENTIFICATION
MECHANISMS
EXPRESSION
NETWORK
URINARY
BINDING
Ubicación del archivo
http://dx.doi.org/10.3390/ijms23095199
Categoría OCDE
Bioquímica y Biología Molecular
Química
Multidisciplinar
Materias
hipertensión
excreción de albúmina urinaria
ARN largo no codificante
exosomas
PLASMA
IDENTIFICACIÓN
MECANISMOS
EXPRESIÓN
RED
URINARIO
UNIÓN
Título de la cita (Recomendado-único)
Biofluid Specificity of Long Non-Coding RNA Profile in Hypertension: Relevance of Exosomal Fraction
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000795285600001
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