Repositorio UFRO · Omeka S

Biofluid Specificity of Long Non-Coding RNA Profile in Hypertension: Relevance of Exosomal Fraction

Primer Autor	Cortes, Raquel
Co-autores	Riffo-Campos, Angela L. Perez-Hernandez, Javier Martinez-Arroyo, Olga Ortega, Ana Flores-Chova, Ana Redon, Josep
Título	Biofluid Specificity of Long Non-Coding RNA Profile in Hypertension: Relevance of Exosomal Fraction
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	Non-coding RNA (ncRNA)-mediated targeting of various genes regulates the molecular mechanisms of the pathogenesis of hypertension (HTN). However, very few circulating long ncRNAs (lncRNAs) have been reported to be altered in essential HTN. The aim of our study was to identify a lncRNA profile in plasma and plasma exosomes associated with urinary albumin excretion in HTN by next-generation sequencing and to assess biological functions enriched in response to albuminuria using GO and KEGG analysis. Plasma exosomes showed higher diversity and fold change of lncRNAs than plasma, and low transcript overlapping was found between the two biofluids. Enrichment analysis identified different biological pathways regulated in plasma or exosome fraction, which were implicated in fatty acid metabolism, extracellular matrix, and mechanisms of sorting ncRNAs into exosomes, while plasma pathways were implicated in genome reorganization, interference with RNA polymerase, and as scaffolds for assembling transcriptional regulators. Our study found a biofluid specific lncRNA profile associated with albuminuria, with higher diversity in exosomal fraction, which identifies several potential targets that may be utilized to study mechanisms of albuminuria and cardiovascular damage.
Tipo de Recurso	artículo original
doi	10.3390/ijms23095199
Formato Recurso	PDF
Palabras Claves	hypertension urinary albumin excretion long non-coding RNA exosomes PLASMA IDENTIFICATION MECHANISMS EXPRESSION NETWORK URINARY BINDING
Ubicación del archivo	http://dx.doi.org/10.3390/ijms23095199
Categoría OCDE	Bioquímica y Biología Molecular Química Multidisciplinar
Materias	hipertensión excreción de albúmina urinaria ARN largo no codificante exosomas PLASMA IDENTIFICACIÓN MECANISMOS EXPRESIÓN RED URINARIO UNIÓN
Disciplinas de la OCDE	Biología Molecular Sistema Cardiovascular y Cardiaco Medicina General e Interna
Versión del recurso (Recomendado-único)	version publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000795285600001
Título de la cita (Recomendado-único)	Biofluid Specificity of Long Non-Coding RNA Profile in Hypertension: Relevance of Exosomal Fraction
Identificador del recurso (Mandatado-único)	artículo original
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0