Repositorio UFRO · Omeka S

Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension

Primer Autor	Cortes, Raquel
Co-autores	Riffo-Campos, Angela L. Perez-Hernandez, Javier Ortega, Ana Martinez-Arroyo, Olga Flores-Chova, Ana Redon, Josep
Título	Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	Non-coding RNA (ncRNA), released into circulation or packaged into exosomes, plays important roles in many biological processes in the kidney. The purpose of the present study is to identify a common ncRNA signature associated with early renal damage and its related molecular pathways. Three individual libraries (plasma and urinary exosomes, and total plasma) were prepared from each hypertensive patient (with or without albuminuria) for ncRNA sequencing analysis. Next, an RNA-based transcriptional regulatory network was constructed. The three RNA biotypes with the greatest number of differentially expressed transcripts were long-ncRNA (lncRNA), microRNA (miRNA) and piwi-interacting RNA (piRNAs). We identified a common 24 ncRNA molecular signature related to hypertension-associated urinary albumin excretion, of which lncRNAs were the most representative. In addition, the transcriptional regulatory network showed five lncRNAs (LINC02614, BAALC-AS1, FAM230B, LOC100505824 and LINC01484) and the miR-301a-3p to play a significant role in network organization and targeting critical pathways regulating filtration barrier integrity and tubule reabsorption. Our study found an ncRNA profile associated with albuminuria, independent of biofluid origin (urine or plasma, circulating or in exosomes) that identifies a handful of potential targets, which may be utilized to study mechanisms of albuminuria and cardiovascular damage.
Tipo de Recurso	artículo original
doi	10.3390/ijms23020823
Formato Recurso	PDF
Palabras Claves	urinary albumin excretion hypertension exosomes plasma non-coding RNA PRACTICE GUIDELINES KIDNEY EXPRESSION MICRORNAS MECHANISMS MANAGEMENT CHANNELS GENES MIRNA
Ubicación del archivo	http://dx.doi.org/10.3390/ijms23020823
Categoría OCDE	Bioquímica y Biología Molecular Química Multidisciplinar
Materias	excreción de albúmina urinaria hipertensión exosomas plasma ARN no codificante GUÍAS DE PRÁCTICA RIÑÓN EXPRESIÓN MICRORNAS MECANISMOS GESTIÓN CANALES GENES MIRNA
Disciplinas de la OCDE	Biología Molecular Genética y Herencia Urología y Nefrología
Título de la cita (Recomendado-único)	Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000747827600001