Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation
Primer Autor |
Salazar, Luis A.
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Co-autores |
Arias, Consuelo
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Título |
Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation
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Editorial |
MDPI
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Revista |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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Lenguaje |
en
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Resumen |
Autophagy is an intracellular mechanism that maintains cellular homeostasis in different tissues. This process declines in cartilage due to aging, which is correlated with osteoarthritis (OA), a multifactorial and degenerative joint disease. Several studies show that microRNAs regulate different steps of autophagy but only a few of them participate in OA. Therefore, epigenetic modifications could represent a therapeutic opportunity during the development of OA. Besides, polyphenols are bioactive components with great potential to counteract diseases, which could reverse altered epigenetic regulation and modify autophagy in cartilage. This review aims to analyze epigenetic mechanisms that are currently associated with autophagy in OA, and to evaluate whether polyphenols are used to reverse the epigenetic alterations generated by aging in the autophagy pathway.
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Tipo de Recurso |
artículo de revisión
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Description |
This research was funded by FONDECYT-ANID, Chile, Grant number 1171765.
Esta investigación fue financiada por FONDECYT-ANID, Chile, Beca número 1171765.
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doi |
10.3390/ijms23010421
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Formato Recurso |
PDF
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Palabras Claves |
autophagy
osteoarthritis
aging
polyphenols
epigenetics
microRNAs
ARTICULAR CHONDROCYTES
CARTILAGE DEGENERATION
DNA METHYLATION
RESVERATROL
APOPTOSIS
CANCER
PROLIFERATION
PATHOGENESIS
DYSFUNCTION
MECHANISMS
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Ubicación del archivo | |
Categoría OCDE |
Bioquímica y Biología Molecular
Química
Multidisciplinar
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Materias |
autofagia
osteoartritis
envejecimiento
polifenoles
epigenética
microARN
CONDROCITOS ARTICULARES
DEGENERACIÓN DEL CARTÍLAGO
METILACIÓN DEL ADN
RESVERATROL
APOPTOSIS
CÁNCER
PROLIFERACIÓN
PATOGENIA
DISFUNCIÓN
MECANISMOS
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Título de la cita (Recomendado-único) |
Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation
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Identificador del recurso (Mandatado-único) |
artículo de revisión
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Versión del recurso (Recomendado-único) |
version publicada
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License |
CC BY 4.0
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Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
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Derechos de acceso |
acceso abierto
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Access Rights |
acceso abierto
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Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 1171765
ANID FONDECYT 1171765
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Id de Web of Science |
WOS:000741783600001
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