Repositorio UFRO · Omeka S

Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation

Primer Autor	Salazar, Luis A.
Co-autores	Arias, Consuelo
Título	Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	Autophagy is an intracellular mechanism that maintains cellular homeostasis in different tissues. This process declines in cartilage due to aging, which is correlated with osteoarthritis (OA), a multifactorial and degenerative joint disease. Several studies show that microRNAs regulate different steps of autophagy but only a few of them participate in OA. Therefore, epigenetic modifications could represent a therapeutic opportunity during the development of OA. Besides, polyphenols are bioactive components with great potential to counteract diseases, which could reverse altered epigenetic regulation and modify autophagy in cartilage. This review aims to analyze epigenetic mechanisms that are currently associated with autophagy in OA, and to evaluate whether polyphenols are used to reverse the epigenetic alterations generated by aging in the autophagy pathway.
Tipo de Recurso	artículo de revisión
Description	This research was funded by FONDECYT-ANID, Chile, Grant number 1171765. Esta investigación fue financiada por FONDECYT-ANID, Chile, Beca número 1171765.
doi	10.3390/ijms23010421
Formato Recurso	PDF
Palabras Claves	autophagy osteoarthritis aging polyphenols epigenetics microRNAs ARTICULAR CHONDROCYTES CARTILAGE DEGENERATION DNA METHYLATION RESVERATROL APOPTOSIS CANCER PROLIFERATION PATHOGENESIS DYSFUNCTION MECHANISMS
Ubicación del archivo	http://dx.doi.org/10.3390/ijms23010421
Categoría OCDE	Bioquímica y Biología Molecular Química Multidisciplinar
Materias	autofagia osteoartritis envejecimiento polifenoles epigenética microARN CONDROCITOS ARTICULARES DEGENERACIÓN DEL CARTÍLAGO METILACIÓN DEL ADN RESVERATROL APOPTOSIS CÁNCER PROLIFERACIÓN PATOGENIA DISFUNCIÓN MECANISMOS
Disciplinas de la OCDE	Biología Celular Biología Molecular Otros Temas de Medicina Clínica
Título de la cita (Recomendado-único)	Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID-FONDECYT 1171765 ANID FONDECYT 1171765
Id de Web of Science	WOS:000741783600001