Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation

Primer Autor
Salazar, Luis A.
Co-autores
Arias, Consuelo
Título
Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation
Editorial
MDPI
Revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje
en
Resumen
Autophagy is an intracellular mechanism that maintains cellular homeostasis in different tissues. This process declines in cartilage due to aging, which is correlated with osteoarthritis (OA), a multifactorial and degenerative joint disease. Several studies show that microRNAs regulate different steps of autophagy but only a few of them participate in OA. Therefore, epigenetic modifications could represent a therapeutic opportunity during the development of OA. Besides, polyphenols are bioactive components with great potential to counteract diseases, which could reverse altered epigenetic regulation and modify autophagy in cartilage. This review aims to analyze epigenetic mechanisms that are currently associated with autophagy in OA, and to evaluate whether polyphenols are used to reverse the epigenetic alterations generated by aging in the autophagy pathway.
Tipo de Recurso
artículo de revisión
Description
This research was funded by FONDECYT-ANID, Chile, Grant number 1171765.
Esta investigación fue financiada por FONDECYT-ANID, Chile, Beca número 1171765.
doi
10.3390/ijms23010421
Formato Recurso
PDF
Palabras Claves
autophagy
osteoarthritis
aging
polyphenols
epigenetics
microRNAs
ARTICULAR CHONDROCYTES
CARTILAGE DEGENERATION
DNA METHYLATION
RESVERATROL
APOPTOSIS
CANCER
PROLIFERATION
PATHOGENESIS
DYSFUNCTION
MECHANISMS
Ubicación del archivo
Categoría OCDE
Bioquímica y Biología Molecular
Química
Multidisciplinar
Materias
autofagia
osteoartritis
envejecimiento
polifenoles
epigenética
microARN
CONDROCITOS ARTICULARES
DEGENERACIÓN DEL CARTÍLAGO
METILACIÓN DEL ADN
RESVERATROL
APOPTOSIS
CÁNCER
PROLIFERACIÓN
PATOGENIA
DISFUNCIÓN
MECANISMOS
Título de la cita (Recomendado-único)
Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID-FONDECYT 1171765
ANID FONDECYT 1171765
Id de Web of Science
WOS:000741783600001
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