Repositorio UFRO · Omeka S

Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review

Primer Autor	Moriel, Patricia
Co-autores	de Godoy Torso, Nadine Pereira, Joao Kleber Novais Visacri, Marilia Berlofa Vasconcelos, Pedro Eduardo Nascimento Silva Loren, Pia Saavedra, Kathleen Saavedra, Nicolas Salazar, Luis A.
Título	Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	The purpose of this systematic review was to map out and summarize scientific evidence on dysregulated microRNAs (miRNAs) that can be possible biomarkers or therapeutic targets for cisplatin nephrotoxicity and have already been tested in humans, animals, or cells. In addition, an in silico analysis of the two miRNAs found to be dysregulated in the majority of studies was performed. A literature search was performed using eight databases for studies published up to 4 July 2021. Two independent reviewers selected the studies and extracted the data, disagreements were resolved by a third and fourth reviewers. A total of 1002 records were identified, of which 30 met the eligibility criteria. All studies were published in English and reported between 2010 and 2021. The main findings were as follows: (a) miR-34a and miR-21 were the main miRNAs identified by the studies as possible biomarkers and therapeutic targets of cisplatin nephrotoxicity, (b) the in silico analysis revealed 124 and 131 different strongly validated targets for miR-34a and miR-21, respectively, and (c) studies in humans remain scarce.
Tipo de Recurso	artículo de revisión
doi	10.3390/ijms222312765
Formato Recurso	PDF
Palabras Claves	cisplatin drug-related side effects and adverse reactions acute kidney injury microRNAs epigenomics biomarkers systematic review ACUTE KIDNEY INJURY CIRCULATING MICRORNAS TUBULAR INJURY IDENTIFICATION PLASMA CANCER APOPTOSIS MIR-21 POPULATION BIOGENESIS
Ubicación del archivo	http://dx.doi.org/10.3390/ijms222312765
Categoría OCDE	Bioquímica y Biología Molecular Química Multidisciplinar
Materias	cisplatino efectos secundarios y reacciones adversas relacionados con los medicamentos lesión renal aguda microARN epigenómica biomarcadores revisión sistemática LESIÓN RENAL AGUDA MICRORNAS CIRCULANTES LESIÓN TUBULAR IDENTIFICACIÓN PLASMA CÁNCER APOPTOSIS MIR-21 POBLACIÓN BIOGÉNESIS
Disciplinas de la OCDE	Urología y Nefrología Biología Molecular Farmacología y Farmacia
Versión del recurso (Recomendado-único)	version publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000734926100001
Título de la cita (Recomendado-único)	Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review
Identificador del recurso (Mandatado-único)	artículo de revisión
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0