Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review

Primer Autor
Moriel, Patricia
Co-autores
de Godoy Torso, Nadine
Pereira, Joao Kleber Novais
Visacri, Marilia Berlofa
Vasconcelos, Pedro Eduardo Nascimento Silva
Loren, Pia
Saavedra, Kathleen
Saavedra, Nicolas
Salazar, Luis A.
Título
Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review
Editorial
MDPI
Revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje
en
Resumen
The purpose of this systematic review was to map out and summarize scientific evidence on dysregulated microRNAs (miRNAs) that can be possible biomarkers or therapeutic targets for cisplatin nephrotoxicity and have already been tested in humans, animals, or cells. In addition, an in silico analysis of the two miRNAs found to be dysregulated in the majority of studies was performed. A literature search was performed using eight databases for studies published up to 4 July 2021. Two independent reviewers selected the studies and extracted the data, disagreements were resolved by a third and fourth reviewers. A total of 1002 records were identified, of which 30 met the eligibility criteria. All studies were published in English and reported between 2010 and 2021. The main findings were as follows: (a) miR-34a and miR-21 were the main miRNAs identified by the studies as possible biomarkers and therapeutic targets of cisplatin nephrotoxicity, (b) the in silico analysis revealed 124 and 131 different strongly validated targets for miR-34a and miR-21, respectively, and (c) studies in humans remain scarce.
Tipo de Recurso
artículo de revisión
doi
10.3390/ijms222312765
Formato Recurso
PDF
Palabras Claves
cisplatin
drug-related side effects and adverse reactions
acute kidney injury
microRNAs
epigenomics
biomarkers
systematic review
ACUTE KIDNEY INJURY
CIRCULATING MICRORNAS
TUBULAR INJURY
IDENTIFICATION
PLASMA
CANCER
APOPTOSIS
MIR-21
POPULATION
BIOGENESIS
Ubicación del archivo
http://dx.doi.org/10.3390/ijms222312765
Categoría OCDE
Bioquímica y Biología Molecular
Química
Multidisciplinar
Materias
cisplatino
efectos secundarios y reacciones adversas relacionados con los medicamentos
lesión renal aguda
microARN
epigenómica
biomarcadores
revisión sistemática
LESIÓN RENAL AGUDA
MICRORNAS CIRCULANTES
LESIÓN TUBULAR
IDENTIFICACIÓN
PLASMA
CÁNCER
APOPTOSIS
MIR-21
POBLACIÓN
BIOGÉNESIS
Disciplinas de la OCDE
Urología y Nefrología
Biología Molecular
Farmacología y Farmacia
Título de la cita (Recomendado-único)
Dysregulated MicroRNAs as Biomarkers or Therapeutic Targets in Cisplatin-Induced Nephrotoxicity: A Systematic Review
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000734926100001
Colecciones
Colección Publicaciones Científicas
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