Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review

Primer Autor
Beltran, Victor
Co-autores
Moaven, Haniyeh
Giacaman, Annesi,Sam, Ye Han
Betancur, Daniel
Mainas, Giuseppe
Tarjomani, Seyed Ali
Donos, Nikolaos
Sousa, Vanessa
Título
Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review
Editorial
MDPI
Revista
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Lenguaje
en
Resumen
The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1 beta and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-alpha reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain((TM)) (EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months.
Tipo de Recurso
artículo de revisión
doi
10.3390/ijerph192114085
Formato Recurso
PDF
Palabras Claves
biomarkers
peri-implantitis
inflammation
therapy
laser
amelogenin
ANTIINFECTIVE MECHANICAL THERAPY
SULCUS FLUID
CLINICAL-PARAMETERS
SURGICAL-TREATMENT
MUCOSITIS
CYTOKINE
DISEASES
Ubicación del archivo
http://dx.doi.org/10.3390/ijerph192114085
Categoría OCDE
Ciencias Ambientales
Salud pública
ambiental y ocupacional
Materias
biomarcadores
periimplantitis
inflamación
terapia
láser
amelogenina
TERAPIA MECÁNICA ANTIINFECTIVA
FLUIDO DEL SULCUS
PARÁMETROS-CLÍNICOS
TRATAMIENTO-QUIRÚRGICO
MUCOSITIS
CITOQUINAS
ENFERMEDADES
Título de la cita (Recomendado-único)
Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000881265800001
Colecciones
Colección Publicaciones Científicas
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