Repositorio UFRO · Omeka S

Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review

Primer Autor	Beltran, Victor
Co-autores	Moaven, Haniyeh Giacaman, Annesi,Sam, Ye Han Betancur, Daniel Mainas, Giuseppe Tarjomani, Seyed Ali Donos, Nikolaos Sousa, Vanessa
Título	Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Lenguaje	en
Resumen	The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1 beta and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-alpha reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain((TM)) (EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months.
Tipo de Recurso	artículo de revisión
doi	10.3390/ijerph192114085
Formato Recurso	PDF
Palabras Claves	biomarkers peri-implantitis inflammation therapy laser amelogenin ANTIINFECTIVE MECHANICAL THERAPY SULCUS FLUID CLINICAL-PARAMETERS SURGICAL-TREATMENT MUCOSITIS CYTOKINE DISEASES
Ubicación del archivo	http://dx.doi.org/10.3390/ijerph192114085
Categoría OCDE	Ciencias Ambientales Salud pública ambiental y ocupacional
Materias	biomarcadores periimplantitis inflamación terapia láser amelogenina TERAPIA MECÁNICA ANTIINFECTIVA FLUIDO DEL SULCUS PARÁMETROS-CLÍNICOS TRATAMIENTO-QUIRÚRGICO MUCOSITIS CITOQUINAS ENFERMEDADES
Disciplinas de la OCDE	Odontología, Cirugía y Medicina Oral Inmunología Farmacología y Farmacia
Versión del recurso (Recomendado-único)	version publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000881265800001
Título de la cita (Recomendado-único)	Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review
Identificador del recurso (Mandatado-único)	artículo de revisión
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0