Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis
| Primer Autor |
Beltran, Victor
|
| Co-autores |
Flores, Valentina
Venegas, Bernardo
Donoso, Wendy
Ulloa, Camilo
Chaparro, Alejandra
Sousa, Vanessa
|
| Título |
Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis
|
| Editorial |
MDPI
|
| Revista |
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
|
| Lenguaje |
en
|
| Resumen |
Currently, researchers are focused on the study of cytokines as predictive biomarkers of peri-implantitis (PI) in order to obtain an early diagnosis and prognosis, and for treatment of the disease. The aim of the study was to characterize the peri-implant soft and hard tissues in patients with a peri-implantitis diagnosis. A descriptive observational study was conducted. Fifteen soft tissue (ST) samples and six peri-implant bone tissue (BT) samples were obtained from 13 patients who were diagnosed with peri-implantitis. All the samples were processed and embedded in paraffin for histological and immunohistochemical analyses. A descriptive and quantitative analysis of mast cells and osteocytes, A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF), osteonectin (ON), and proportional to-smooth muscle actin (proportional to-SMA) was performed. We observed the presence of mast cells in peri-implant soft tissue in all samples (mean 9.21 number of mast cells) and osteocytes in peri-implant hard tissue in all samples (mean 37.17 number of osteocytes). The expression of APRIL-ST was 32.17% +/- 6.39%, and that of APRIL-BT was 7.09% +/- 5.94%. The BAFF-ST expression was 17.26 +/- 12.90%, and the BAFF-BT was 12.16% +/- 6.30%. The mean percentage of ON was 7.93% +/- 3.79%, and proportional to-SMA was 1.78% +/- 3.79%. It was concluded that the expression of APRIL and BAFF suggests their involvement in the bone resorption observed in peri-implantitis. The lower expression of osteonectin in the peri-implant bone tissue can also be associated with a deficiency in the regulation of bone remodeling and the consequent peri-implant bone loss.
|
| Tipo de Recurso |
artículo original
|
| Description |
This study received funding from Project REDI 0170658 and FONDEF ID20i279, of the Chilean National Agency for Research and Development (ANID).
Este estudio recibió financiamiento del Proyecto REDI 0170658 y FONDEF ID20i279, de la Agencia Nacional de Investigación y Desarrollo (ANID) de Chile.
|
| doi |
10.3390/ijerph19148388
|
| Formato Recurso |
PDF
|
| Palabras Claves |
peri-implantitis
peri-implant disease
APRIL/BAFF
osteonectin
alpha-smooth muscle actin
oral health
CREVICULAR FLUID
SERUM-LEVELS
EXPRESSION
ALPHA
CELLS
APRIL
PERIODONTITIS
BAFF
|
| Ubicación del archivo | |
| Categoría OCDE |
Ciencias Ambientales
Salud pública
ambiental y ocupacional
|
| Materias |
periimplantitis
enfermedad periimplantaria
ABRIL/BAFF
osteonectina
actina alfa-músculo liso
salud bucal
FLUIDO CREVICULAR
NIVELES SÉRUCOS
EXPRESIÓN
CÉLULAS ALFA
ABRIL
PERIODONTITIS
BAFF
|
| Título de la cita (Recomendado-único) |
Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID REDI 0170658
ANID-FONDEF ID20i279
ANID FONDEF ID20i279
|
| Id de Web of Science |
WOS:000831678900001
|
cienciaabierta.ufro.cl
ciencia.abierta@ufrontera.cl