Repositorio
Institucional

Beltran, Victor

Flores, Valentina

Venegas, Bernardo

Donoso, Wendy

Ulloa, Camilo

Chaparro, Alejandra

Sousa, Vanessa

Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis

MDPI

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH

en

Currently, researchers are focused on the study of cytokines as predictive biomarkers of peri-implantitis (PI) in order to obtain an early diagnosis and prognosis, and for treatment of the disease. The aim of the study was to characterize the peri-implant soft and hard tissues in patients with a peri-implantitis diagnosis. A descriptive observational study was conducted. Fifteen soft tissue (ST) samples and six peri-implant bone tissue (BT) samples were obtained from 13 patients who were diagnosed with peri-implantitis. All the samples were processed and embedded in paraffin for histological and immunohistochemical analyses. A descriptive and quantitative analysis of mast cells and osteocytes, A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF), osteonectin (ON), and proportional to-smooth muscle actin (proportional to-SMA) was performed. We observed the presence of mast cells in peri-implant soft tissue in all samples (mean 9.21 number of mast cells) and osteocytes in peri-implant hard tissue in all samples (mean 37.17 number of osteocytes). The expression of APRIL-ST was 32.17% +/- 6.39%, and that of APRIL-BT was 7.09% +/- 5.94%. The BAFF-ST expression was 17.26 +/- 12.90%, and the BAFF-BT was 12.16% +/- 6.30%. The mean percentage of ON was 7.93% +/- 3.79%, and proportional to-SMA was 1.78% +/- 3.79%. It was concluded that the expression of APRIL and BAFF suggests their involvement in the bone resorption observed in peri-implantitis. The lower expression of osteonectin in the peri-implant bone tissue can also be associated with a deficiency in the regulation of bone remodeling and the consequent peri-implant bone loss.

artículo original

This study received funding from Project REDI 0170658 and FONDEF ID20i279, of the Chilean National Agency for Research and Development (ANID).

Este estudio recibió financiamiento del Proyecto REDI 0170658 y FONDEF ID20i279, de la Agencia Nacional de Investigación y Desarrollo (ANID) de Chile.

10.3390/ijerph19148388

PDF

peri-implantitis

peri-implant disease

APRIL/BAFF

osteonectin

alpha-smooth muscle actin

oral health

CREVICULAR FLUID

SERUM-LEVELS

EXPRESSION

ALPHA

CELLS

APRIL

PERIODONTITIS

BAFF

Ciencias Ambientales

Salud pública

ambiental y ocupacional

periimplantitis

enfermedad periimplantaria

ABRIL/BAFF

osteonectina

actina alfa-músculo liso

salud bucal

FLUIDO CREVICULAR

NIVELES SÉRUCOS

EXPRESIÓN

CÉLULAS ALFA

ABRIL

PERIODONTITIS

BAFF

Odontología, Cirugía y Medicina Oral

Inmunología

Otros Temas de Medicina Clínica

Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis

artículo original

version publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

ANID REDI 0170658

ANID-FONDEF ID20i279

ANID FONDEF ID20i279

WOS:000831678900001