Repositorio UFRO · Omeka S

Role of Self-Sampling for Cervical Cancer Screening: Diagnostic Test Properties of Three Tests for the Diagnosis of HPV in Rural Communities of Cuenca, Ecuador

Primer Autor	Vega Crespo, Bernardo
Co-autores	Alejandra Neira, Vivian Ortiz Segarra, Jose Maldonado Rengel, Ruth Lopez, Diana Paz Orellana, Maria Gomez, Andrea Jose Vicuna, Maria Mejia, Jorge Benoy, Ina Parron Carreno, Tesifon Verhoeven, Veronique
Título	Role of Self-Sampling for Cervical Cancer Screening: Diagnostic Test Properties of Three Tests for the Diagnosis of HPV in Rural Communities of Cuenca, Ecuador
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Lenguaje	en
Resumen	Background: HPV primary screening has shown effectiveness for cancer prevention, however, gynaecological examination is considered uncomfortable. Self-sampling methods increase the acceptance of screening. The aim of this study is to compare the sensitivity and specificity of clinician sampling versus vaginal and urine self-sampling for HPV diagnosis. Methods: A diagnostic test study was conducted in a rural parish of Cuenca, Ecuador. A total of 120 women participated. Each participant self-collected urine and vaginal samples and underwent clinician sampling for HPV testing. The latter was considered as the golden standard. All three samples were processed with the same amplification and hybridization protocol for HPV detection (Hybribio) following the manufacturer's instructions. Results: Characteristics of the participants were: median age 35 years, 40.8% married, 46.7% had a primary level of education, and median age of sexual onset, 17.6 years. The prevalence of any type of HPV with clinician sampling was 15.0%, 17.5% with urine sampling and 18.3% with vaginal self-sampling. Self-sampling sensitivity reached 94.4% (IC 74.2-99.9), and specificity 92.1% (IC 85.2-95.9). Urine sampling had a sensitivity of 88.8% (IC 67.2, 96.9), and specificity 94.1% (IC 67.2-96.9). The negative predictive value was 98.9% (IC 94.2-99.8) for vaginal self-sampling and 97.6% (IC 92.6-99.4) for urine sampling. Conclusions: This study shows that vaginal and urine self-sampling methods have similar sensitivity and specificity compared with clinician sampling for the diagnosis of HPV. The correlation between HPV genotypes among the three tests is satisfactory.
Tipo de Recurso	artículo original
doi	10.3390/ijerph19084619
Formato Recurso	PDF
Palabras Claves	HPV self-sampling urine sampling clinician sampling sensitivity and specificity COLLECTED SAMPLES WOMEN ACCEPTABILITY DNA INFECTION URINE SMEAR
Ubicación del archivo	http://dx.doi.org/10.3390/ijerph19084619
Categoría OCDE	Ciencias Ambientales Salud pública ambiental y ocupacional
Materias	VPH automuestreo muestreo de orina muestreo clínico sensibilidad y especificidad MUESTRAS RECOPILADAS MUJERES ACEPTABILIDAD ADN INFECCIÓN ORINA FROSO
Disciplinas de la OCDE	Biotecnología Relacionada con la Salud Salud Pública y Ambiental Virología
Título de la cita (Recomendado-único)	Role of Self-Sampling for Cervical Cancer Screening: Diagnostic Test Properties of Three Tests for the Diagnosis of HPV in Rural Communities of Cuenca, Ecuador
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000786197800001