Hematological abnormalities in immunosuppressed patients with COVID-19: Evidence from a single center. A cross sectional study

Primer Autor
Giacaman, Annesi
Co-autores
Henriquez, Wolfrang
Tolosa, Guillermo
Prado, Aurora
Jerez, Roxana
Reveco, Yenny
Martinez, Carlos
Baumert, Carlos
Rodriguez, Belen
Sanhueza, Basty
Jose Orellana, Juan
Inostroza, Jaime
Título
Hematological abnormalities in immunosuppressed patients with COVID-19: Evidence from a single center. A cross sectional study
Editorial
ELSEVIER
Revista
INTERNATIONAL IMMUNOPHARMACOLOGY
Lenguaje
en
Resumen
Background: Changes in hematological parameters in patients with COVID-19 are emerging as important features of the disease in the general population. In the present study we aimed to explore the hematological characteristics and its prevalence proportion ratio in patients with immunosuppression with COVID-19. Aim: To explore the differences between immunosuppressed and non-immunosuppressed patients, with and without COVID-19 from a hematological perspective. Methods: This cross-sectional study reports on the baseline complete blood count in patients attending the HHA Hospital, in Chile. The study reports descriptive characteristics of the population, including sex, age, ethnicity, corticoids and biological therapy scheme and a complete report of blood test results. A total of 476 patients were enrolled in this study from October of 2020 to April 2021. Results: Findings revels a significant increment (p value <= 0.001) on the median of total neutrophils and leucocytes, and in platelet-lymphocyte ratio (PLR), neutrophil- lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) in immunosuppressed patients with COVID-19 (IS(+)) and immunocompetent patients with COVID19 (IC(+)) compared with their respective controls. By contrast, a significant reduction on the median of lymphocytes, and eosinophiles was observed in IS(+) individuals compared with its controls. Also, the red blood cell count, hemoglobin, hematocrit, and mean corpuscular hemoglobin concentration were significantly reduced in IS(+) patients, whereas red blood cell, distribution width and mean corpuscular volume, were significantly higher in patients with COVID-19. Conclusion: Rapid blood tests, including, neutrophil, lymphocytes count and PLR, NLR can be used for early assessment and management of patients with immunosuppression.
Tipo de Recurso
artículo original
Description
This study was founded by the ANID, the Chilean National Research and Development Agency. The research project ID is COVID0605.
Este estudio fue fundado por la ANID, la Agencia Nacional de Investigación y Desarrollo de Chile. El ID del proyecto de investigación es COVID0605.
doi
10.1016/j.intimp.2022.108862
Formato Recurso
PDF
Palabras Claves
Immunosuppressed patients
White blood cells
Red blood cells
Platelets
COVID-19
NLR
PLR
Ubicación del archivo
http://dx.doi.org/10.1016/j.intimp.2022.108862
Categoría OCDE
Inmunología
Farmacología y farmacia
Materias
Pacientes inmunodeprimidos
Glóbulos blancos
Glóbulos rojos
Plaquetas
COVID-19
NLR
PLR
Disciplinas de la OCDE
Hematología
Enfermedades Infecciosas
Otros Temas de Medicina Clínica
Título de la cita (Recomendado-único)
Hematological abnormalities in immunosuppressed patients with COVID-19: Evidence from a single center. A cross sectional study
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID COVID0605
Id de Web of Science
WOS:000810406300003
Colecciones
Colección Publicaciones Científicas
Colección ANID
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