Repositorio
Institucional

Calina, Daniela

Asgharian, Parina

Quispe, Cristina

Herrera-Bravo, Jesus

Sabernavaei, Mahsa

Hosseini, Kamran

Forouhandeh, Haleh

Ebrahimi, Tahereh

Sharafi-Badr, Paria

Tarhriz, Vahideh

Soofiyani, Saiedeh Razi

Helon, Pawel

Rajkovic, Jovana

Dastan, Sevgi Durna

Docea, Anca Oana

Sharifi-Rad, Javad

Calina, Daniela

Koch, Wojciech

Cho, William C.

Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update

FRONTIERS MEDIA SA

FRONTIERS IN PHARMACOLOGY

en

Neuropsychiatric diseases are a group of disorders that cause significant morbidity and disability. The symptoms of psychiatric disorders include anxiety, depression, eating disorders, autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, and conduct disorder. Various medicinal plants are frequently used as therapeutics in traditional medicine in different parts of the world. Nowadays, using medicinal plants as an alternative medication has been considered due to their biological safety. Despite the wide range of medications, many patients are unable to tolerate the side effects and eventually lose their response. By considering the therapeutic advantages of medicinal plants in the case of side effects, patients may prefer to use them instead of chemical drugs. Today, the use of medicinal plants in traditional medicine is diverse and increasing, and these plants are a precious heritage for humanity. Investigation about traditional medicine continues, and several studies have indicated the basic pharmacology and clinical efficacy of herbal medicine. In this article, we discuss five of the most important and common psychiatric illnesses investigated in various studies along with conventional therapies and their pharmacological therapies. For this comprehensive review, data were obtained from electronic databases such as MedLine/PubMed, Science Direct, Web of Science, EMBASE, DynaMed Plus, ScienceDirect, and TRIP database. Preclinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common psychiatric disorders. The mechanisms of action of the analyzed biocompounds are presented in detail. The bioactive compounds analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in the pharmacotherapy of neuropsychiatric diseases. Although comparative studies have been carefully reviewed in the preclinical pharmacology field, no clinical studies have been found to confirm the efficacy of herbal medicines compared to FDA-approved medicines for the treatment of mental disorders. Therefore, future clinical studies are needed to accelerate the potential use of natural compounds in the management of these diseases.

artículo de revisión

10.3389/fphar.2022.926607

PDF

neuropsychiatric disorders

natural compounds

pharmacological mechanisms

bioactive compounds

preclinical pharmacology

AUTISM SPECTRUM DISORDERS

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

INDUCED STATUS EPILEPTICUS

MAJOR DEPRESSIVE DISORDER

VALPROATE-INDUCED AUTISM

BLOOD-BRAIN-BARRIER

ANTIDEPRESSANT-LIKE

OXIDATIVE STRESS

NEUROTROPHIC FACTOR

COGNITIVE IMPAIRMENT

Farmacología y farmacia

trastornos neuropsiquiátricos

compuestos naturales

mecanismos farmacológicos

compuestos bioactivos

farmacología preclínica

TRASTORNOS DEL ESPECTRO AUTISTA

DÉFICIT DE ATENCIÓN/TRASTORNO DE HIPERACTIVIDAD

ESTADO EPILÉPTICO INDUCIDO

TRASTORNO DEPRESIVO MAYOR

AUTISMO INDUCIDO POR VALPROATO

BARRERA SANGUÍNEA-CEREBRAL

PARA ANTIDEPRESIVO

OXIDATIVO ESTRÉS

FACTOR NEUROTROFICO

DETERIORO COGNITIVO

Psiquiatría

Farmacología y Farmacia

Neurociencias

Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update

artículo de revisión

version publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:000862332700001