Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update
| Primer Autor |
Calina, Daniela
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| Co-autores |
Asgharian, Parina
Quispe, Cristina
Herrera-Bravo, Jesus
Sabernavaei, Mahsa
Hosseini, Kamran
Forouhandeh, Haleh
Ebrahimi, Tahereh
Sharafi-Badr, Paria
Tarhriz, Vahideh
Soofiyani, Saiedeh Razi
Helon, Pawel
Rajkovic, Jovana
Dastan, Sevgi Durna
Docea, Anca Oana
Sharifi-Rad, Javad
Calina, Daniela
Koch, Wojciech
Cho, William C.
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| Título |
Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update
|
| Editorial |
FRONTIERS MEDIA SA
|
| Revista |
FRONTIERS IN PHARMACOLOGY
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| Lenguaje |
en
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| Resumen |
Neuropsychiatric diseases are a group of disorders that cause significant morbidity and disability. The symptoms of psychiatric disorders include anxiety, depression, eating disorders, autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, and conduct disorder. Various medicinal plants are frequently used as therapeutics in traditional medicine in different parts of the world. Nowadays, using medicinal plants as an alternative medication has been considered due to their biological safety. Despite the wide range of medications, many patients are unable to tolerate the side effects and eventually lose their response. By considering the therapeutic advantages of medicinal plants in the case of side effects, patients may prefer to use them instead of chemical drugs. Today, the use of medicinal plants in traditional medicine is diverse and increasing, and these plants are a precious heritage for humanity. Investigation about traditional medicine continues, and several studies have indicated the basic pharmacology and clinical efficacy of herbal medicine. In this article, we discuss five of the most important and common psychiatric illnesses investigated in various studies along with conventional therapies and their pharmacological therapies. For this comprehensive review, data were obtained from electronic databases such as MedLine/PubMed, Science Direct, Web of Science, EMBASE, DynaMed Plus, ScienceDirect, and TRIP database. Preclinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common psychiatric disorders. The mechanisms of action of the analyzed biocompounds are presented in detail. The bioactive compounds analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in the pharmacotherapy of neuropsychiatric diseases. Although comparative studies have been carefully reviewed in the preclinical pharmacology field, no clinical studies have been found to confirm the efficacy of herbal medicines compared to FDA-approved medicines for the treatment of mental disorders. Therefore, future clinical studies are needed to accelerate the potential use of natural compounds in the management of these diseases.
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| Tipo de Recurso |
artículo de revisión
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| doi |
10.3389/fphar.2022.926607
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| Formato Recurso |
PDF
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| Palabras Claves |
neuropsychiatric disorders
natural compounds
pharmacological mechanisms
bioactive compounds
preclinical pharmacology
AUTISM SPECTRUM DISORDERS
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
INDUCED STATUS EPILEPTICUS
MAJOR DEPRESSIVE DISORDER
VALPROATE-INDUCED AUTISM
BLOOD-BRAIN-BARRIER
ANTIDEPRESSANT-LIKE
OXIDATIVE STRESS
NEUROTROPHIC FACTOR
COGNITIVE IMPAIRMENT
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| Ubicación del archivo | |
| Categoría OCDE |
Farmacología y farmacia
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| Materias |
trastornos neuropsiquiátricos
compuestos naturales
mecanismos farmacológicos
compuestos bioactivos
farmacología preclínica
TRASTORNOS DEL ESPECTRO AUTISTA
DÉFICIT DE ATENCIÓN/TRASTORNO DE HIPERACTIVIDAD
ESTADO EPILÉPTICO INDUCIDO
TRASTORNO DEPRESIVO MAYOR
AUTISMO INDUCIDO POR VALPROATO
BARRERA SANGUÍNEA-CEREBRAL
PARA ANTIDEPRESIVO
OXIDATIVO ESTRÉS
FACTOR NEUROTROFICO
DETERIORO COGNITIVO
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| Disciplinas de la OCDE |
Psiquiatría
Farmacología y Farmacia
Neurociencias
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| Título de la cita (Recomendado-único) |
Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update
|
| Identificador del recurso (Mandatado-único) |
artículo de revisión
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
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| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
|
| Id de Web of Science |
WOS:000862332700001
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