Contribution of MicroRNAs in Chemoresistance to Cisplatin in the Top Five Deadliest Cancer: An Updated Review
| Primer Autor |
Salazar, Luis A.
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| Co-autores |
Loren, Pia
Saavedra, Nicolas
Saavedra, Kathleen
Torso, Nadine De Godoy
Visacri, Marilia Berlofa
Moriel, Patricia
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| Título |
Contribution of MicroRNAs in Chemoresistance to Cisplatin in the Top Five Deadliest Cancer: An Updated Review
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| Editorial |
FRONTIERS MEDIA SA
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| Revista |
FRONTIERS IN PHARMACOLOGY
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| Lenguaje |
en
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| Resumen |
Cisplatin (DDP) is a well-known anticancer drug used for the treatment of numerous human cancers in solid organs, including bladder, breast, cervical, head and neck squamous cell, ovarian, among others. Its most important mode of action is the DNA-platinum adducts formation, inducing DNA damage response, silencing or activating several genes to induce apoptosis, these mechanisms result in genetics and epigenetics modifications. The ability of DDP to induce tumor cell death is often challenged by the presence of anti-apoptotic regulators, leading to chemoresistance, wherein many patients who have or will develop DDP-resistance. Cancer cells resist the apoptotic effect of chemotherapy, being a problem that severely restricts the successful results of treatment for many human cancers. In the last 30 years, researchers have discovered there are several types of RNAs, and among the most important are non-coding RNAs (ncRNAs), a class of RNAs that are not involved in protein production, but they are implicated in gene expression regulation, and representing the 98% of the human genome non-translated. Some ncRNAs of great interest are long ncRNAs, circular RNAs, and microRNAs (miRs). Accumulating studies reveal that aberrant miRs expression can affect the development of chemotherapy drug resistance, by modulating the expression of relevant target proteins. Thus, identifying molecular mechanisms underlying chemoresistance development is fundamental for setting strategies to improve the prognosis of patients with different types of cancer. Therefore, this review aimed to identify and summarize miRs that modulate chemoresistance in DDP-resistant in the top five deadliest cancer, both in vitro and in vivo human models.
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| Tipo de Recurso |
artículo de revisión
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| Description |
This research was funded by ANID-FAPESP (Grant No. 19/132501), FONDECYT (Grant No. 1171765), Programa de Formacion de Investigadores Postdoctorales, VRIP, Universidad de La Frontera, Temuco, Chile (Code VRIP 21001) and FONDECYT Postdoctoral Grant No. 3220404 awarded to PL.
|
| doi |
10.3389/fphar.2022.831099
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| Formato Recurso |
PDF
|
| Palabras Claves |
microRNA
drug-resistance
cisplatin
sensitivity
cancer
CELL LUNG-CANCER
EPITHELIAL-MESENCHYMAL TRANSITION
HUMAN GASTRIC-CANCER
NF-KAPPA-B
MODULATES MULTIDRUG-RESISTANCE
NONSMALL CELL
HEPATOCELLULAR-CARCINOMA
COLORECTAL-CANCER
DRUG-RESISTANCE
ADENOCARCINOMA CELLS
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| Ubicación del archivo | |
| Categoría OCDE |
Farmacología y farmacia
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| Materias |
microARN
resistencia a medicamentos
cisplatino
sensibilidad
cáncer
CÉLULAS DE CÁNCER DE PULMÓN
TRANSICIÓN EPITELIAL-MESENQUIMAL
CÁNCER GÁSTRICO HUMANO
NF-KAPPA-B
MODULA LA RESISTENCIA A MULTIDROGAS
CÉLULAS NO PEQUEÑAS
CARCINOMA-HEPATOCELULAR
CÁNCER-COLORECTAL
DROGAS -CÉLULAS DE RESISTENCIA
ADENOCARCINOMA
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| Título de la cita (Recomendado-único) |
Contribution of MicroRNAs in Chemoresistance to Cisplatin in the Top Five Deadliest Cancer: An Updated Review
|
| Identificador del recurso (Mandatado-único) |
artículo de revisión
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| Versión del recurso (Recomendado-único) |
version publicada
|
| License |
CC BY 4.0
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| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 1171765
ANID-FONDECYT 3220404
ANID-FAPESP 19/132501
UFRO VRIP21001
ANID FONDECYT 1171765
ANID FONDECYT 3220404
ANID FAPESP 19/132501
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| Id de Web of Science |
WOS:000790481800001
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