Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2

Primer Autor
dos Santos, Alef Aragao Carneiro
Co-autores
Rodrigues, Luiz Eduardo
Alecrim-Zeza, Amanda Lins
Ferreira, Liliane de Araujo
Trettel, Caio dos Santos
Gimenes, Gabriela Mandu
da Silva, Adelson Fernandes
Sousa-Filho, Celso Pereira Batista
Serdan, Tamires Duarte Afonso
Levada-Pires, Adriana Cristina
Hatanaka, Elaine
Borges, Fernanda Teixeira
de Barros, Marcelo Paes
Cury-Boaventura, Maria Fernanda
Bertolini, Gisele Lopes
Cassolla, Priscila
Marzuca-Nassr, Gabriel Nasri
Vitzel, Kaio Fernando
Pithon-Curi, Tania Cristina
Masi, Laureane Nunes
Curi, Rui
Gorjao, Renata
Hirabara, Sandro Massao
Título
Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2
Editorial
FRONTIERS MEDIA SA
Revista
FRONTIERS IN MICROBIOLOGY
Lenguaje
en
Resumen
Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechanisms involved are not yet fully elucidated. Some potential mechanisms involved in the COVID-19-induced tissue dysfunction are proposed, such as: (a) High expression and levels of proinflammatory cytokines, including TNF-alpha IL-6, IL-1 beta, INF-alpha and INF-beta, increasing the systemic and tissue inflammatory state, (b) Induction of oxidative stress due to redox imbalance, resulting in cell injury or death induced by elevated production of reactive oxygen species, and (c) Deregulation of the renin-angiotensin-aldosterone system, exacerbating the inflammatory and oxidative stress responses. In this review, we discuss the main metabolic disturbances observed in different target tissues of SARS-CoV-2 and the potential mechanisms involved in these changes associated with the tissue dysfunction.
Tipo de Recurso
artículo de revisión
doi
10.3389/fmicb.2022.1037467
Formato Recurso
PDF
Palabras Claves
metabolism
inflammation
oxidative stress
renin-angiotensin-aldosterone system
SARS-CoV-2
RENIN-ANGIOTENSIN SYSTEM
ACUTE KIDNEY INJURY
FATTY-ACID-METABOLISM
ACUTE-RENAL-FAILURE
ACUTE LUNG INJURY
GLUCOSE-METABOLISM
HYDROGEN-PEROXIDE
OXIDATIVE STRESS
URGENT NEED
COVID-19
Ubicación del archivo
http://dx.doi.org/10.3389/fmicb.2022.1037467
Categoría OCDE
Microbiología
Materias
metabolismo
inflamación
estrés oxidativo
sistema renina-angiotensina-aldosterona
SARS-CoV-2
SISTEMA RENINA-ANGIOTENSINA
LESIÓN RENINA AGUDA
METABOLISMO DE ÁCIDOS GRASOS
INSUFICIENCIA RENAL-AGUDA
LESIÓN PULMONAR AGUDA
METABOLISMO DE LA GLUCOSA
HIDRÓGENO -PERÓXIDO
ESTRÉS OXIDATIVO
NECESIDAD URGENTE
COVID-19
Disciplinas de la OCDE
Virología
Inmunología
Enfermedades Infecciosas
Título de la cita (Recomendado-único)
Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000889851400001
Colecciones
Colección Publicaciones Científicas
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