Repositorio UFRO · Omeka S

Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2

Primer Autor	dos Santos, Alef Aragao Carneiro
Co-autores	Rodrigues, Luiz Eduardo Alecrim-Zeza, Amanda Lins Ferreira, Liliane de Araujo Trettel, Caio dos Santos Gimenes, Gabriela Mandu da Silva, Adelson Fernandes Sousa-Filho, Celso Pereira Batista Serdan, Tamires Duarte Afonso Levada-Pires, Adriana Cristina Hatanaka, Elaine Borges, Fernanda Teixeira de Barros, Marcelo Paes Cury-Boaventura, Maria Fernanda Bertolini, Gisele Lopes Cassolla, Priscila Marzuca-Nassr, Gabriel Nasri Vitzel, Kaio Fernando Pithon-Curi, Tania Cristina Masi, Laureane Nunes Curi, Rui Gorjao, Renata Hirabara, Sandro Massao
Título	Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2
Editorial	FRONTIERS MEDIA SA
Revista	FRONTIERS IN MICROBIOLOGY
Lenguaje	en
Resumen	Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechanisms involved are not yet fully elucidated. Some potential mechanisms involved in the COVID-19-induced tissue dysfunction are proposed, such as: (a) High expression and levels of proinflammatory cytokines, including TNF-alpha IL-6, IL-1 beta, INF-alpha and INF-beta, increasing the systemic and tissue inflammatory state, (b) Induction of oxidative stress due to redox imbalance, resulting in cell injury or death induced by elevated production of reactive oxygen species, and (c) Deregulation of the renin-angiotensin-aldosterone system, exacerbating the inflammatory and oxidative stress responses. In this review, we discuss the main metabolic disturbances observed in different target tissues of SARS-CoV-2 and the potential mechanisms involved in these changes associated with the tissue dysfunction.
Tipo de Recurso	artículo de revisión
doi	10.3389/fmicb.2022.1037467
Formato Recurso	PDF
Palabras Claves	metabolism inflammation oxidative stress renin-angiotensin-aldosterone system SARS-CoV-2 RENIN-ANGIOTENSIN SYSTEM ACUTE KIDNEY INJURY FATTY-ACID-METABOLISM ACUTE-RENAL-FAILURE ACUTE LUNG INJURY GLUCOSE-METABOLISM HYDROGEN-PEROXIDE OXIDATIVE STRESS URGENT NEED COVID-19
Ubicación del archivo	http://dx.doi.org/10.3389/fmicb.2022.1037467
Categoría OCDE	Microbiología
Materias	metabolismo inflamación estrés oxidativo sistema renina-angiotensina-aldosterona SARS-CoV-2 SISTEMA RENINA-ANGIOTENSINA LESIÓN RENINA AGUDA METABOLISMO DE ÁCIDOS GRASOS INSUFICIENCIA RENAL-AGUDA LESIÓN PULMONAR AGUDA METABOLISMO DE LA GLUCOSA HIDRÓGENO -PERÓXIDO ESTRÉS OXIDATIVO NECESIDAD URGENTE COVID-19
Disciplinas de la OCDE	Virología Inmunología Enfermedades Infecciosas
Título de la cita (Recomendado-único)	Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000889851400001