Untargeted Metabolomics Approach of Cross-Adaptation in Salmonella Enterica Induced by Major Compounds of Essential Oils

Primer Autor
Santos, Cledir
Co-autores
Pagnossa, Jorge Pamplona
Rocchetti, Gabriele
Bezerra, Jadson Diogo Pereira
Batiha, Gaber El-Saber
El-Masry, Eman A.
Mahmoud, Mohamed H.
Alsayegh, Abdulrahman A.
Mashraqi, Abdullah
Cocconcelli, Pier Sandro
Lucini, Luigi
Hilsdorf Piccoli, Roberta
Título
Untargeted Metabolomics Approach of Cross-Adaptation in Salmonella Enterica Induced by Major Compounds of Essential Oils
Editorial
FRONTIERS MEDIA SA
Revista
FRONTIERS IN MICROBIOLOGY
Lenguaje
en
Resumen
Cross-adaptation phenomena in bacterial populations, induced by sublethal doses of antibacterial solutions, are a major problem in the field of food safety. In this regard, essential oils and their major compounds appear as an effective alternative to common sanitizers in food industry environments. The present study aimed to evaluate the untargeted metabolomics perturbations of Salmonella enterica serovar Enteritidis that has been previously exposed to the sublethal doses of the major components of essential oils: cinnamaldehyde, citral, and linalool (CIN, CIT, and LIN, respectively). Cinnamaldehyde appeared to be the most efficient compound in the assays evaluating the inhibitory effects [0.06% (v/v) as MBC]. Also, preliminary tests exhibited a phenotype of adaptation in planktonic and sessile cells of S. Enteritidis when exposed to sublethal doses of linalool, resulting in tolerance to previously lethal concentrations of citral. A metabolomics approach on S. Enteritidis provided an important insight into the phenomenon of cross-adaptation induced by sublethal doses of major compounds of some essential oils. In addition, according to the results obtained, when single molecules were used, many pathways may be involved in bacterial tolerance, which could be different from the findings revealed in previous studies regarding the use of phytocomplex of essential oils. Orthogonal projection to latent structures (OPLS) proved to be an interesting predictive model to demonstrate the adaptation events in pathogenic bacteria because of the global engagement to prevent and control foodborne outbreaks.
Tipo de Recurso
artículo original
doi
10.3389/fmicb.2022.769110
Formato Recurso
PDF
Palabras Claves
bacterial tolerance
biofilm
terpenes
untargeted metabolomics
discriminant analysis
STAPHYLOCOCCUS-AUREUS
CINNAMON
CINNAMALDEHYDE
CONSTITUENTS
RESISTANCE
STRAINS
Ubicación del archivo
http://dx.doi.org/10.3389/fmicb.2022.769110
Categoría OCDE
Microbiología
Materias
tolerancia bacteriana
biopelícula
terpenos
metabolómica no dirigida
análisis discriminante
STAPHYLOCOCCUS-AUREUS
CANELA
CINNAMALDEHÍDO
CONSTITUENTES
RESISTENCIA
CEPAS
Disciplinas de la OCDE
Microbiología
Biotecnología Alimentaria
Tecnología de los Alimentos
Título de la cita (Recomendado-único)
Untargeted Metabolomics Approach of Cross-Adaptation in Salmonella Enterica Induced by Major Compounds of Essential Oils
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000807884400001
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