Repositorio UFRO · Omeka S

Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors in Corynebacterium striatum

Primer Autor	Abanto, Michel
Co-autores	Leyton-Carcaman, Benjamin
Título	Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors in Corynebacterium striatum
Editorial	FRONTIERS MEDIA SA
Revista	FRONTIERS IN MICROBIOLOGY
Lenguaje	en
Resumen	In recent years, epidemiological studies of infectious agents have focused mainly on the pathogen and stable components of its genome. The use of these stable components makes it possible to know the evolutionary or epidemiological relationships of the isolates of a particular pathogen. Under this approach, focused on the pathogen, the identification of resistance genes is a complementary stage of a bacterial characterization process or an appendix of its epidemiological characterization, neglecting its genetic components' acquisition or dispersal mechanisms. Today we know that a large part of antibiotic resistance is associated with mobile elements. Corynebacterium striatum, a bacterium from the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. Despite the different existing mobile genomic elements, there is evidence that acquired resistance genes are coupled to insertion sequences in C. striatum. This perspective article reviews the insertion sequences linked to resistance genes, their relationship to evolutionary lineages, epidemiological characteristics, and the niches the strains inhabit. Finally, we evaluate the potential of the insertion sequences for their application as a descriptor of epidemiological scenarios, allowing us to anticipate the emergence of multidrug-resistant lineages.
Tipo de Recurso	artículo original
doi	10.3389/fmicb.2022.806576
Formato Recurso	PDF
Palabras Claves	insertion sequences epidemiological markers Corynebacterium striatum emerging pathogen multi-drug resistance mobile elements AMR machine-learning PLASMIDS TUBERCULOSIS DYNAMICS IMPACT
Ubicación del archivo	http://dx.doi.org/10.3389/fmicb.2022.806576
Categoría OCDE	Microbiología
Materias	secuencias de inserción marcadores epidemiológicos Corynebacterium striatum patógeno emergente resistencia a múltiples fármacos elementos móviles AMR aprendizaje automático PLÁSMIDOS TUBERCULOSIS DINÁMICA IMPACTO
Disciplinas de la OCDE	Microbiología Biología Molecular Enfermedades Infecciosas
Versión del recurso (Recomendado-único)	version publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000750576700001
Título de la cita (Recomendado-único)	Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors in Corynebacterium striatum
Identificador del recurso (Mandatado-único)	artículo original
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0