Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors in Corynebacterium striatum

Primer Autor
Abanto, Michel
Co-autores
Leyton-Carcaman, Benjamin
Título
Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors in Corynebacterium striatum
Editorial
FRONTIERS MEDIA SA
Revista
FRONTIERS IN MICROBIOLOGY
Lenguaje
en
Resumen
In recent years, epidemiological studies of infectious agents have focused mainly on the pathogen and stable components of its genome. The use of these stable components makes it possible to know the evolutionary or epidemiological relationships of the isolates of a particular pathogen. Under this approach, focused on the pathogen, the identification of resistance genes is a complementary stage of a bacterial characterization process or an appendix of its epidemiological characterization, neglecting its genetic components' acquisition or dispersal mechanisms. Today we know that a large part of antibiotic resistance is associated with mobile elements. Corynebacterium striatum, a bacterium from the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. Despite the different existing mobile genomic elements, there is evidence that acquired resistance genes are coupled to insertion sequences in C. striatum. This perspective article reviews the insertion sequences linked to resistance genes, their relationship to evolutionary lineages, epidemiological characteristics, and the niches the strains inhabit. Finally, we evaluate the potential of the insertion sequences for their application as a descriptor of epidemiological scenarios, allowing us to anticipate the emergence of multidrug-resistant lineages.
Tipo de Recurso
artículo original
doi
10.3389/fmicb.2022.806576
Formato Recurso
PDF
Palabras Claves
insertion sequences
epidemiological markers
Corynebacterium striatum
emerging pathogen
multi-drug resistance
mobile elements
AMR
machine-learning
PLASMIDS
TUBERCULOSIS
DYNAMICS
IMPACT
Ubicación del archivo
http://dx.doi.org/10.3389/fmicb.2022.806576
Categoría OCDE
Microbiología
Materias
secuencias de inserción
marcadores epidemiológicos
Corynebacterium striatum
patógeno emergente
resistencia a múltiples fármacos
elementos móviles
AMR
aprendizaje automático
PLÁSMIDOS
TUBERCULOSIS
DINÁMICA
IMPACTO
Disciplinas de la OCDE
Microbiología
Biología Molecular
Enfermedades Infecciosas
Título de la cita (Recomendado-único)
Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors in Corynebacterium striatum
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000750576700001
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