Repositorio UFRO · Omeka S

Genome-Wide Identification of Aldehyde Oxidase Genes in Moths and Butterflies Suggests New Insights Into Their Function as Odorant-Degrading Enzymes

Primer Autor	Venthur, Herbert
Co-autores	Godoy, Ricardo Mutis, Ana Carabajal Paladino, Leonela
Título	Genome-Wide Identification of Aldehyde Oxidase Genes in Moths and Butterflies Suggests New Insights Into Their Function as Odorant-Degrading Enzymes
Editorial	FRONTIERS MEDIA SA
Revista	FRONTIERS IN ECOLOGY AND EVOLUTION
Lenguaje	en
Resumen	Aldehyde oxidases (AOXs) are common detoxifying enzymes in several organisms. In insects, AOXs act in xenobiotic metabolism and as odorant-degrading enzymes (ODEs). These last appear as crucial enzymes in the life cycle of insects, helping to reset their olfactory system, particularly in lepidopterans, which fulfill important ecological roles (e.g., pollination or destructive life cycles). A comprehensive understanding of their olfactory system has provided opportunities to study key chemosensory proteins. However, no significant advance has been made around lepidopteran AOXs research, and even less around butterflies, a recently evolved lineage. In this study we have identified novel AOX gene families in moths and butterflies in order to understand their role as ODEs. Eighteen genomes from both moths and butterflies were used for phylogenetics, molecular evolution and sequence analyses. We identified 164 AOXs, from which 91 are new. Their phylogeny showed two main clades that are potentially related to odorant-degrading function, where both moths and butterflies have AOXs. A first ODE-related clade seems to have a non-ditrysian origin, likely related to plant volatiles. A second ODE-related clade could be more pheromone-biased. Molecular evolution analysis suggests a slight purifying selection process, though a number of sites appeared under positive selection. ODE-related AOXs have changed a phenylalanine residue by proline in the active site. Finally, this study could serve as a reference for further evolutionary and functional studies around Lepidopteran AOXs.
Tipo de Recurso	artículo original
doi	10.3389/fevo.2022.823119
Formato Recurso	PDF
Palabras Claves	Lepidoptera insect olfaction aldehyde oxidase genome phylogenetics MULTIPLE SEQUENCE ALIGNMENT CODON-SUBSTITUTION MODELS SEX-PHEROMONE BOMBYX-MORI BINDING-PROTEINS LEPIDOPTERA ANTENNAE EVOLUTION CARBOXYLESTERASE SPECIFICITIES
Ubicación del archivo	http://dx.doi.org/10.3389/fevo.2022.823119
Categoría OCDE	Ecología
Materias	Lepidoptera olfato de insectos aldehído oxidasa genoma filogenética ALINEACIÓN DE SECUENCIAS MÚLTIPLES MODELOS DE SUSTITUCIÓN DE CODONES FEROMONAS SEXUALES BOMBYX-MORI PROTEÍNAS DE UNIÓN LEPIDOPTERA ANTENAS EVOLUCIÓN CARBOXILESTERASA ESPECIFICIDADES
Disciplinas de la OCDE	Zoología, Ornitología, Entomología y Comportamiento Biológico Genética y Herencia Biología Molecular
Título de la cita (Recomendado-único)	Genome-Wide Identification of Aldehyde Oxidase Genes in Moths and Butterflies Suggests New Insights Into Their Function as Odorant-Degrading Enzymes
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000760595700001