Can the immunological system of the upper respiratory tract, improved by physical exercise, act as a first immunological barrier against SARS-CoV-2?

Primer Autor
Ojeda-Aravena, Alex
Co-autores
Azocar-Gallardo, Jairo
Largo, Jorge Carrizo
Hernandez-Mosqueira, Claudio
Título
Can the immunological system of the upper respiratory tract, improved by physical exercise, act as a first immunological barrier against SARS-CoV-2?
Editorial
TAYLOR & FRANCIS LTD
Revista
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
Lenguaje
en
Resumen
Introduction The main route of transmission of SARS-CoV-2 is the upper respiratory tract via cell membranes, including angiotensin-converting enzyme 2 (ACE2) and transmembrane host-associated serine protease transmembrane serine protease 2 (TMPRSS2). Both enzymes present in the nasal epithelium are the first direct point of contact for SARS-CoV-2. In this sense, the mucosal immune mechanisms of the upper respiratory tract, including immunoglobulin A (IgA), could be enhanced by physical exercise and be the first defense mechanism against the transmission and infection of SARS-CoV-2. Areas covered The authors reviewed recent biomedical literature available in databases related to the effects of exercise and training modalities on IgA concentration levels in the upper respiratory tract in different populations. Expert opinion According to the biomedical literature reviewed, physical exercise can decrease or improve the level of IgA concentrations. However, it is important to take into account factors such as training load, recovery during the exercise session and between training, as well as the exercise modality. Furthermore, the characteristics of the target population should be taken into account to maximize the adaptive immune response to adequately strengthen the upper respiratory tract and potentially be a barrier against SARS-CoV-2 infection.
Tipo de Recurso
artículo original
doi
10.1080/14787210.2022.2065983
Formato Recurso
PDF
Palabras Claves
Physical exercise
Immunity
SARS-COV-2
COVID-19
IMMUNOGLOBULIN-A
SECRETORY IGA
RECOVERY
Ubicación del archivo
http://dx.doi.org/10.1080/14787210.2022.2065983
Categoría OCDE
Enfermedades infecciosas
Microbiología
Farmacología y farmacia
Materias
Ejercicio físico
Inmunidad
SARS-COV-2
COVID-19
INMUNOGLOBULINA-A
SECRETORIA IGA
RECUPERACIÓN
Disciplinas de la OCDE
Inmunología
Virología
Ciencias del Deporte y Acondicionamiento Físico
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version publicada
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WOS:000794292100001
Título de la cita (Recomendado-único)
Can the immunological system of the upper respiratory tract, improved by physical exercise, act as a first immunological barrier against SARS-CoV-2?
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artículo original
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